AutismKB 2.0

Annotation Details for PRMT5


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Basic Information Top
Gene Symbol:PRMT5 ( HRMT1L5,IBP72,JBP1,SKB1,SKB1Hs )
Gene Full Name: protein arginine methyltransferase 5
Band: 14q11.2
Quick LinksEntrez ID:10419; OMIM: 604045; Uniprot ID:ANM5_HUMAN; ENSEMBL ID: ENSG00000100462; HGNC ID: 10894
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus-
GO:0005634NAS-nucleus18404153
GO:0005654TAS-nucleoplasm-
GO:0005737IDA-cytoplasm22952863
GO:0005794IDA-Golgi apparatus20421892
GO:0005829IDA-cytosol18984161
GO:0005829TAS-cytosol-
GO:0034709IDA-methylosome18984161
GO:0035097IDA-histone methyltransferase complex23048031
GO:0043234IEA-protein complex-
GO ID Evidence Qualifier GO_term References
GO:0001046ISS-core promoter sequence-specific DNA binding-
GO:0003714ISS-transcription corepressor activity-
GO:0005515IPI-protein binding11756452
GO:0008168IDA-methyltransferase activity15369763
GO:0008327IDA-methyl-CpG binding25284789
GO:0008469TAS-histone-arginine N-methyltransferase activity-
GO:0016274IDA-protein-arginine N-methyltransferase activity20421892
GO:0016274TAS-protein-arginine N-methyltransferase activity-
GO:0032403IEA-protein complex binding-
GO:0035243EXP-protein-arginine omega-N symmetric methyltransferase activity19011621
GO:0035243IMP-protein-arginine omega-N symmetric methyltransferase activity17709427
GO:0043021IPI-ribonucleoprotein complex binding17709427
GO:0044020IMP-histone methyltransferase activity (H4-R3 specific)25284789
GO:0046982IDA-protein heterodimerization activity18495660
GO ID Evidence Qualifier GO_term References
GO:0000387IMP-spliceosomal snRNP assembly17709427
GO:0000387TAS-spliceosomal snRNP assembly-
GO:0006353IMP-DNA-templated transcription, termination26700805
GO:0006355IBA-regulation of transcription, DNA-templated-
GO:0007088TAS-regulation of mitotic nuclear division9843966
GO:0008283TAS-cell proliferation9843966
GO:0018216IMP-peptidyl-arginine methylation17709427
GO:0019918IEA-peptidyl-arginine methylation, to symmetrical-dimethyl arginine-
GO:0032922ISS-circadian regulation of gene expression-
GO:0035246IDA-peptidyl-arginine N-methylation15369763
GO:0042118IMP-endothelial cell activation22269951
GO:0043985ISS-histone H4-R3 methylation-
GO:0043985NAS-histone H4-R3 methylation18404153
GO:0044030IEA-regulation of DNA methylation-
GO:0045596IEA-negative regulation of cell differentiation-
GO:0048714IEA-positive regulation of oligodendrocyte differentiation-
GO:0070372IEA-regulation of ERK1 and ERK2 cascade-
GO:0090161IMP-Golgi ribbon formation20421892
GO:0097421IEA-liver regeneration-
GO:1901796TAS-regulation of signal transduction by p53 class mediator-
GO:1903507IEA-negative regulation of nucleic acid-templated transcription-
GO:1904992IGI-positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway26554819
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PRMT5PRDM110710816699504 18992153 Affinity Capture-Western
PRMT5PRDM111568816699504 18992153 Affinity Capture-Western
PRMT5CLNS1A1076179556550 11713266 11756452 19520849 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PRMT5CLNS1A1156889556550 11713266 11756452 19520849 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PRMT5DNMT3A10812519234465 Reconstituted Complex
PRMT5DNMT3A11568819234465 Reconstituted Complex
PRMT5FBL10839914583623 Affinity Capture-MS
PRMT5FBL11568814583623 Affinity Capture-MS
PRMT5HSP90AA110955217409432 Affinity Capture-Western
PRMT5HSP90AA111568817409432 Affinity Capture-Western
PRMT5JAK110991910531356 Reconstituted Complex
PRMT5JAK111568810531356 Reconstituted Complex
PRMT5JAK211568810531356 Reconstituted Complex; Two-hybrid
PRMT5JAK210992010531356 Reconstituted Complex; Two-hybrid
PRMT5JAK310992110531356 Reconstituted Complex
PRMT5JAK311568810531356 Reconstituted Complex
PRMT5MBP11032511152681 Biochemical Activity
PRMT5MBP11568811152681 Biochemical Activity
PRMT5MEF2D11037319188441 Reconstituted Complex
PRMT5MEF2D11568819188441 Reconstituted Complex
PRMT5MYOD111073719188441 20195544 Affinity Capture-MS; Reconstituted Complex
PRMT5MYOD111568819188441 20195544 Affinity Capture-MS; Reconstituted Complex
PRMT5MYOG11568819188441 Reconstituted Complex
PRMT5MYOG11073919188441 Reconstituted Complex
PRMT5NCL11568817974993 Affinity Capture-Western
PRMT5NCL11077117974993 Affinity Capture-Western
PRMT5SKI11238819032343 Affinity Capture-Western
PRMT5SKI11568819032343 Affinity Capture-Western
PRMT5SMARCA211568814559996 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
PRMT5SMARCA211247914559996 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
PRMT5SMARCA411568814559996 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
PRMT5SMARCA411248114559996 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
PRMT5SMARCB111568814559996 Reconstituted Complex
PRMT5SMARCB111248214559996 Reconstituted Complex
PRMT5SMARCC111568814559996 Reconstituted Complex
PRMT5SMARCC111248314559996 Reconstituted Complex
PRMT5SMARCE111248914559996 Reconstituted Complex
PRMT5SMARCE111568814559996 Reconstituted Complex
PRMT5SNRPD111251611713266 Reconstituted Complex
PRMT5SNRPD111568811713266 Reconstituted Complex
PRMT5SNRPD311251811713266 Affinity Capture-MS; Reconstituted Complex
PRMT5SNRPD311568811713266 Affinity Capture-MS; Reconstituted Complex
PRMT5SUPT5H11269712718890 Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity
PRMT5SUPT5H11568812718890 Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity
PRMT5TYK211568810531356 Reconstituted Complex
PRMT5TYK211314810531356 Reconstituted Complex
PRMT5ZNF22411355019741270 Affinity Capture-Western; Reconstituted Complex
PRMT5ZNF22411568819741270 Affinity Capture-Western; Reconstituted Complex
PRMT5HIST2H2AC11393415670829 Biochemical Activity
PRMT5HIST2H2AC11568815670829 Biochemical Activity
PRMT5HIST1H3A11394614559996 15485929 15670829 Biochemical Activity
PRMT5HIST1H3A11568814559996 15485929 15670829 Biochemical Activity
PRMT5HIST1H4A11568814559996 15485929 15670829 Biochemical Activity
PRMT5HIST1H4A11395514559996 15485929 15670829 Biochemical Activity
PRMT5MBD211444516428440 16980624 Affinity Capture-Western
PRMT5MBD211568816428440 16980624 Affinity Capture-Western
PRMT5CTDP111459715670829 Affinity Capture-Western
PRMT5CTDP111568815670829 Affinity Capture-Western
PRMT5PHYHIP11568816169070 Two-hybrid
PRMT5PHYHIP11513916169070 Two-hybrid
PRMT5PRMT511568810531356 11152681 Affinity Capture-Western
WDR77PRMT511568811756452 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
WDR77PRMT512253211756452 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
SIN3APRMT511743914559996 Affinity Capture-Western; Reconstituted Complex
SIN3APRMT511568814559996 Affinity Capture-Western; Reconstituted Complex
LSM11PRMT511568816087681 Affinity Capture-Western
LSM11PRMT512639416087681 Affinity Capture-Western
OLA1PRMT511568816169070 Two-hybrid
OLA1PRMT511891716169070 Two-hybrid
KHDRBS2PRMT511568817643375 Affinity Capture-MS
KHDRBS2PRMT512843617643375 Affinity Capture-MS
MYSM1PRMT512536317707232 Affinity Capture-MS
MYSM1PRMT511568817707232 Affinity Capture-MS
PAXIP1PRMT511662517925232 Affinity Capture-MS
PAXIP1PRMT511568817925232 Affinity Capture-MS
JUBPRMT511568818347060 Affinity Capture-Western
JUBPRMT512439318347060 Affinity Capture-Western
NFE4PRMT511568819234465 Affinity Capture-Western
NFE4PRMT512180019234465 Affinity Capture-Western
CTNNBL1PRMT512112321385873 Affinity Capture-MS
CTNNBL1PRMT511568821385873 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1351645
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030616-585'