Gene Symbol:	VAV3 ( FLJ40431 )
Gene Full Name:	vav 3 guanine nucleotide exchange factor
Band:	1p13.3
Quick Links	Entrez ID:10451; OMIM: 605541; Uniprot ID:VAV3_HUMAN; ENSEMBL ID: ENSG00000134215; HGNC ID: 12659
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0005829	TAS	-	cytosol	-
GO:0005886	IEA	-	plasma membrane	-
GO:0070062	IDA	-	extracellular exosome	23376485

GO ID	Evidence	Qualifier	GO_term	References
GO:0005070	TAS	-	SH3/SH2 adaptor activity	10523675
GO:0005085	EXP	-	guanyl-nucleotide exchange factor activity	8990121
GO:0005085	TAS	-	guanyl-nucleotide exchange factor activity	-
GO:0005089	TAS	-	Rho guanyl-nucleotide exchange factor activity	-
GO:0005096	TAS	-	GTPase activator activity	10523675
GO:0005154	IEA	-	epidermal growth factor receptor binding	-
GO:0005515	IPI	-	protein binding	12577067
GO:0030676	IEA	-	Rac guanyl-nucleotide exchange factor activity	-
GO:0046872	IEA	-	metal ion binding	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0001525	IEA	-	angiogenesis	-
GO:0006906	IEA	-	vesicle fusion	-
GO:0006974	IMP	-	cellular response to DNA damage stimulus	17875758
GO:0007229	IEA	-	integrin-mediated signaling pathway	-
GO:0007264	IEA	-	small GTPase mediated signal transduction	-
GO:0008361	IGI	-	regulation of cell size	22467863
GO:0008361	IGI	NOT	regulation of cell size	22467863
GO:0009967	IEA	-	positive regulation of signal transduction	-
GO:0030032	IEA	-	lamellipodium assembly	-
GO:0030168	TAS	-	platelet activation	-
GO:0030593	IEA	-	neutrophil chemotaxis	-
GO:0030890	IMP	-	positive regulation of B cell proliferation	17875758
GO:0035023	IEA	-	regulation of Rho protein signal transduction	-
GO:0038095	TAS	-	Fc-epsilon receptor signaling pathway	-
GO:0038096	TAS	-	Fc-gamma receptor signaling pathway involved in phagocytosis	-
GO:0042493	IMP	-	response to drug	17875758
GO:0043065	TAS	-	positive regulation of apoptotic process	-
GO:0043087	IGI	-	regulation of GTPase activity	22467863
GO:0043547	IEA	-	positive regulation of GTPase activity	-
GO:0043552	IEA	-	positive regulation of phosphatidylinositol 3-kinase activity	-
GO:0045785	IEA	-	positive regulation of cell adhesion	-
GO:0048010	TAS	-	vascular endothelial growth factor receptor signaling pathway	-
GO:0048013	TAS	-	ephrin receptor signaling pathway	-
GO:0050853	IMP	-	B cell receptor signaling pathway	17875758
GO:0051056	TAS	-	regulation of small GTPase mediated signal transduction	-

Gene Symbol	Interactant	Interaction ID	References	Description
VAV3	RHOA	115715	10523675	Reconstituted Complex
VAV3	RHOA	106880	10523675	Reconstituted Complex
VAV3	RHOG	115715	10523675	Reconstituted Complex
VAV3	RHOG	106884	10523675	Reconstituted Complex
VAV3	EGFR	108276	10938113	Affinity Capture-Western
VAV3	EGFR	115715	10938113	Affinity Capture-Western
VAV3	GRB2	115715	11094073 12577067 20936779	Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
VAV3	GRB2	109142	11094073 12577067 20936779	Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
VAV3	IGF1R	115715	11094073	Affinity Capture-Western
VAV3	IGF1R	109701	11094073	Affinity Capture-Western
VAV3	INSR	115715	11094073	Affinity Capture-Western
VAV3	INSR	109854	11094073	Affinity Capture-Western
VAV3	PDGFRB	111185	10938113	Affinity Capture-Western
VAV3	PDGFRB	115715	10938113	Affinity Capture-Western
VAV3	RAC1	115715	10523675	Reconstituted Complex
VAV3	RAC1	111817	10523675	Reconstituted Complex
VAV3	ROS1	115715	11094073	Affinity Capture-Western
VAV3	ROS1	112025	11094073	Affinity Capture-Western
VAV3	SHC1	112361	11094073	Affinity Capture-Western
VAV3	SHC1	115715	11094073	Affinity Capture-Western

AutismKB 2.0

Annotation Details for VAV3