AutismKB 2.0

Annotation Details for TAB1


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Basic Information Top
Gene Symbol:TAB1 ( 3'-Tab1,MAP3K7IP1,MGC57664 )
Gene Full Name: TGF-beta activated kinase 1/MAP3K7 binding protein 1
Band: 22q13.1
Quick LinksEntrez ID:10454; OMIM: 602615; Uniprot ID:TAB1_HUMAN; ENSEMBL ID: ENSG00000100324; HGNC ID: 18157
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0010008TAS-endosome membrane-
GO:0016607IDA-nuclear speck-
GO:0043234IEA-protein complex-
GO ID Evidence Qualifier GO_term References
GO:0004722IEA-protein serine/threonine phosphatase activity-
GO:0005515IPI-protein binding10094049
GO:0008047TAS-enzyme activator activity8638164
GO:0019209IEA-kinase activator activity-
GO:0032403IEA-protein complex binding-
GO:0048273IEA-mitogen-activated protein kinase p38 binding-
GO ID Evidence Qualifier GO_term References
GO:0000185IEA-activation of MAPKKK activity-
GO:0000187TAS-activation of MAPK activity-
GO:0001701IEA-in utero embryonic development-
GO:0002223TAS-stimulatory C-type lectin receptor signaling pathway-
GO:0002755TAS-MyD88-dependent toll-like receptor signaling pathway-
GO:0003007IEA-heart morphogenesis-
GO:0003279IEA-cardiac septum development-
GO:0006470IEA-protein dephosphorylation-
GO:0007179IEA-transforming growth factor beta receptor signaling pathway-
GO:0007249TAS-I-kappaB kinase/NF-kappaB signaling-
GO:0007254TAS-JNK cascade-
GO:0016579TAS-protein deubiquitination-
GO:0030324IEA-lung development-
GO:0035904IEA-aorta development-
GO:0038095TAS-Fc-epsilon receptor signaling pathway-
GO:0051092TAS-positive regulation of NF-kappaB transcription factor activity-
GO:0060976IEA-coronary vasculature development-
GO:0070423TAS-nucleotide-binding oligomerization domain containing signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TAB1XIAP1157179878061 12048196 Affinity Capture-Western; Two-hybrid
TAB1XIAP1068289878061 12048196 Affinity Capture-Western; Two-hybrid
TAB1MAPK1411571711847341 Affinity Capture-Western; Reconstituted Complex
TAB1MAPK1410781911847341 Affinity Capture-Western; Reconstituted Complex
TAB1SMAD611026611737269 Affinity Capture-Western
TAB1SMAD611571711737269 Affinity Capture-Western
TAB1SMAD711571711737269 12589052 Affinity Capture-Western
TAB1SMAD711026711737269 12589052 Affinity Capture-Western
TAB1MAP3K711571710094049 10838074 12975377 14670075 Affinity Capture-Western; Phenotypic Enhancement
TAB1MAP3K711274810094049 10838074 12975377 14670075 Affinity Capture-Western; Phenotypic Enhancement
TAB1TRAF211571714743216 Affinity Capture-MS
TAB1TRAF211303814743216 Affinity Capture-MS
TAB1TRAF611571710094049 10882101 19112497 Affinity Capture-Western
TAB1TRAF611304110094049 10882101 19112497 Affinity Capture-Western
ZMYND11TAB11157179663660 Affinity Capture-Western; Two-hybrid
ZMYND11TAB11159899663660 Affinity Capture-Western; Two-hybrid
TAB2TAB111571710882101 14670075 14743216 Affinity Capture-MS; Affinity Capture-Western
TAB2TAB111674010882101 14670075 14743216 Affinity Capture-MS; Affinity Capture-Western
TAB3TAB111571714670075 Affinity Capture-Western
TAB3TAB112921614670075 Affinity Capture-Western
Gene Symbol Interactant Interaction ID References Description
TAB1MAPK1420833712829618 TAB1 interacts with an unspecified isoform of p38.
TAB1MAP3K72083349878061 An unspecified isoform of TAK1 interacts with TAB1. This interaction was modeled on a demonstrated interaction between TAK1 from an unspecified species and human TAB1.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1913763
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-060628-1'