AutismKB 2.0

Annotation Details for MERTK


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Basic Information Top
Gene Symbol:MERTK ( MER,MGC133349,RP38,c-mer )
Gene Full Name: c-mer proto-oncogene tyrosine kinase
Band: 2q13
Quick LinksEntrez ID:10461; OMIM: 604705; Uniprot ID:MERTK_HUMAN; ENSEMBL ID: ENSG00000153208; HGNC ID: 7027
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0001750IEA-photoreceptor outer segment-
GO:0005615IDA-extracellular space18395422
GO:0005737IDA-cytoplasm18395422
GO:0005886TAS-plasma membrane-
GO:0005887TAS-integral component of plasma membrane8086340
GO:0016028IDA-rhabdomere19204785
GO ID Evidence Qualifier GO_term References
GO:0004714IEA-transmembrane receptor protein tyrosine kinase activity-
GO:0005515IPI-protein binding20103767
GO:0005524IEA-ATP binding-
GO ID Evidence Qualifier GO_term References
GO:0001779IEA-natural killer cell differentiation-
GO:0001818IEA-negative regulation of cytokine production-
GO:0006468TAS-protein phosphorylation8086340
GO:0006909IMP-phagocytosis19204785
GO:0007166TAS-cell surface receptor signaling pathway8086340
GO:0007267TAS-cell-cell signaling8086340
GO:0007283IEA-spermatogenesis-
GO:0018108IEA-peptidyl-tyrosine phosphorylation-
GO:0030168IEA-platelet activation-
GO:0032940IEA-secretion by cell-
GO:0034446IEA-substrate adhesion-dependent cell spreading-
GO:0043277IEA-apoptotic cell clearance-
GO:0043491IEA-protein kinase B signaling-
GO:0050766IDA-positive regulation of phagocytosis18395422
GO:0050900TAS-leukocyte migration-
GO:0051250IEA-negative regulation of lymphocyte activation-
GO:0060041IEA-retina development in camera-type eye-
GO:0060068IEA-vagina development-
GO:0097350IEA-neutrophil clearance-
GO:2000107IMP-negative regulation of leukocyte apoptotic process23353780
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MERTKGAS61088918939948 Reconstituted Complex
MERTKGAS61157248939948 Reconstituted Complex
MERTKIKBKG11408920098747 Reconstituted Complex
MERTKIKBKG11572420098747 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:96965
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-081107-1'