AutismKB 2.0

Annotation Details for PRDX4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PRDX4 ( AOE37-2,PRX-4 )
Gene Full Name: peroxiredoxin 4
Band: Xp22.11
Quick LinksEntrez ID:10549; OMIM: 606506; Uniprot ID:PRDX4_HUMAN; ENSEMBL ID: ENSG00000123131; HGNC ID: 17169
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005615IEA-extracellular space-
GO:0005634IDA-nucleus21630459
GO:0005739IEA-mitochondrion-
GO:0005790IEA-smooth endoplasmic reticulum-
GO:0005829IEA-cytosol-
GO:0034774TAS-secretory granule lumen-
GO:0070062IDA-extracellular exosome19199708
GO:1904813TAS-ficolin-1-rich granule lumen-
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding17644091
GO:0008379TAS-thioredoxin peroxidase activity9388242
GO:0042803IEA-protein homodimerization activity-
GO ID Evidence Qualifier GO_term References
GO:0007252TAS-I-kappaB phosphorylation9388242
GO:0007283IEA-spermatogenesis-
GO:0008584IEA-male gonad development-
GO:0019471IEA-4-hydroxyproline metabolic process-
GO:0022417IEA-protein maturation by protein folding-
GO:0030198IEA-extracellular matrix organization-
GO:0043312TAS-neutrophil degranulation-
GO:0045454IEA-cell redox homeostasis-
GO:0055114IEA-oxidation-reduction process-
GO:0072593IEA-reactive oxygen species metabolic process-
GO:0098869IEA-cellular oxidant detoxification-
GO:2000255IEA-negative regulation of male germ cell proliferation-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PRDX4PRDX11158009388242 Two-hybrid
PRDX4PRDX11110899388242 Two-hybrid
PRDX4TTF211403612927788 Two-hybrid
PRDX4TTF211580012927788 Two-hybrid
PRDX4PRDX41158009388242 Reconstituted Complex; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1859815
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018