Gene Symbol:	SORBS1 ( CAP,DKFZp451C066,DKFZp586P1422,FLAF2,FLJ12406,KIAA1296,R85FL,SH3D5,SH3P12,SORB1 )
Gene Full Name:	sorbin and SH3 domain containing 1
Band:	10q24.1
Quick Links	Entrez ID:10580; OMIM: 605264; Uniprot ID:SRBS1_HUMAN; ENSEMBL ID: ENSG00000095637; HGNC ID: 14565
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0001725	ISS	-	stress fiber	-
GO:0005634	IDA	-	nucleus	11371513
GO:0005813	IDA	-	centrosome	-
GO:0005829	ISS	-	cytosol	9447983
GO:0005829	TAS	-	cytosol	-
GO:0005886	IDA	-	plasma membrane	-
GO:0005899	IDA	colocalizes_with	insulin receptor complex	11374898
GO:0005913	ISS	-	cell-cell adherens junction	-
GO:0005915	TAS	-	zonula adherens	10085297
GO:0005924	ISS	-	cell-substrate adherens junction	-
GO:0005925	IDA	-	focal adhesion	-
GO:0016363	IEA	-	nuclear matrix	-
GO:0045121	ISS	-	membrane raft	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0003779	TAS	-	actin binding	10085297
GO:0005070	IC	-	SH3/SH2 adaptor activity	11374898
GO:0005070	ISS	-	SH3/SH2 adaptor activity	9447983
GO:0005158	IDA	-	insulin receptor binding	11374898
GO:0005515	IPI	-	protein binding	11371513
GO:0008092	TAS	-	cytoskeletal protein binding	10085297

GO ID	Evidence	Qualifier	GO_term	References
GO:0006936	TAS	-	muscle contraction	-
GO:0007160	TAS	-	cell-matrix adhesion	10085297
GO:0008286	ISS	-	insulin receptor signaling pathway	-
GO:0009967	IEA	-	positive regulation of signal transduction	-
GO:0015758	ISS	-	glucose transport	-
GO:0032869	ISS	-	cellular response to insulin stimulus	11001060
GO:0043149	ISS	-	stress fiber assembly	-
GO:0045725	ISS	-	positive regulation of glycogen biosynthetic process	11001060
GO:0046326	ISS	-	positive regulation of glucose import	11001060
GO:0046889	ISS	-	positive regulation of lipid biosynthetic process	11001060
GO:0048041	ISS	-	focal adhesion assembly	-
GO:0090004	ISS	-	positive regulation of establishment of protein localization to plasma membrane	-

Gene Symbol	Interactant	Interaction ID	References	Description
SORBS1	ABL1	106543	11374898	Affinity Capture-Western
SORBS1	ABL1	115831	11374898	Affinity Capture-Western
SORBS1	CBL	107315	12504111 15128873	Affinity Capture-Western
SORBS1	CBL	115831	12504111 15128873	Affinity Capture-Western
SORBS1	PTK2B	108480	15128873	Affinity Capture-Western
SORBS1	PTK2B	115831	15128873	Affinity Capture-Western
SORBS1	INPPL1	109848	12504111	Affinity Capture-Western; Two-hybrid
SORBS1	INPPL1	115831	12504111	Affinity Capture-Western; Two-hybrid
SORBS1	INSM1	109853	12079283	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SORBS1	INSM1	115831	12079283	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SORBS1	INSR	109854	11374898	Affinity Capture-Western
SORBS1	INSR	115831	11374898	Affinity Capture-Western
SORBS1	EIF6	115831	17353931	Affinity Capture-MS
SORBS1	EIF6	109898	17353931	Affinity Capture-MS
SORBS1	MLLT4	110447	10085297	Affinity Capture-Western; Reconstituted Complex
SORBS1	MLLT4	115831	10085297	Affinity Capture-Western; Reconstituted Complex
SORBS1	VCL	113257	10085297	Affinity Capture-Western; Reconstituted Complex
SORBS1	VCL	115831	10085297	Affinity Capture-Western; Reconstituted Complex
SORBS1	MAP4K3	114063	20936779	Two-hybrid
SORBS1	MAP4K3	115831	20936779	Two-hybrid
SORBS1	FLOT1	115506	11001060 11481476 15128873	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SORBS1	FLOT1	115831	11001060 11481476 15128873	Affinity Capture-Western; Reconstituted Complex; Two-hybrid

AutismKB 2.0

Annotation Details for SORBS1