AutismKB 2.0

Annotation Details for SH2B2


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Basic Information Top
Gene Symbol:SH2B2 ( APS )
Gene Full Name: SH2B adaptor protein 2
Band: 7q22.1
Quick LinksEntrez ID:10603; OMIM: 605300; Uniprot ID:SH2B2_HUMAN; ENSEMBL ID: ENSG00000160999; HGNC ID: 17381
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IDA-cytoplasm9989826
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane9989826
GO ID Evidence Qualifier GO_term References
GO:0004871IEA-signal transducer activity-
GO:0005070IDA-SH3/SH2 adaptor activity9233773
GO:0005515IPI-protein binding15737992
GO:0008269IDA-JAK pathway signal transduction adaptor activity10374881
GO ID Evidence Qualifier GO_term References
GO:0007165TAS-signal transduction9233773
GO:0007596TAS-blood coagulation-
GO:0008286ISS-insulin receptor signaling pathway-
GO:0009967IEA-positive regulation of signal transduction-
GO:0035556IDA-intracellular signal transduction9233773
GO:0046425IEA-regulation of JAK-STAT cascade-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SH2B2CBL11585010374881 15737992 18273061 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
SH2B2CBL10731510374881 15737992 18273061 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
SH2B2GRB21091429856458 Affinity Capture-Western
SH2B2GRB21158509856458 Affinity Capture-Western
SH2B2JAK211585010374881 Biochemical Activity
SH2B2JAK210992010374881 Biochemical Activity
SH2B2NTRK11109699856458 Affinity Capture-Western; Two-hybrid
SH2B2NTRK11158509856458 Affinity Capture-Western; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1345171
  • Data Attributes: MGI curated and HomoloGene calculated
No data