AutismKB 2.0

Annotation Details for SIX2


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Basic Information Top
Gene Symbol:SIX2 ( - )
Gene Full Name: SIX homeobox 2
Band: 2p21
Quick LinksEntrez ID:10736; OMIM: 604994; Uniprot ID:SIX2_HUMAN; ENSEMBL ID: ENSG00000170577; HGNC ID: 10888
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IEA-nucleus-
GO ID Evidence Qualifier GO_term References
GO:0000978IEA-RNA polymerase II core promoter proximal region sequence-specific DNA binding-
GO:0001077IEA-transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding-
GO:0003700NAS-transcription factor activity, sequence-specific DNA binding10773454
GO:0008134IEA-transcription factor binding-
GO:0032403IEA-protein complex binding-
GO ID Evidence Qualifier GO_term References
GO:0001822IMP-kidney development18305125
GO:0001822ISS-kidney development-
GO:0002062IEA-chondrocyte differentiation-
GO:0003337ISS-mesenchymal to epithelial transition involved in metanephros morphogenesis-
GO:0006366IEA-transcription from RNA polymerase II promoter-
GO:0006606IEA-protein import into nucleus-
GO:0007501ISS-mesodermal cell fate specification-
GO:0008283IDA-cell proliferation22995329
GO:0009653TAS-anatomical structure morphogenesis10773454
GO:0009948ISS-anterior/posterior axis specification-
GO:0016477IDA-cell migration22995329
GO:0030278IEA-regulation of ossification-
GO:0032330IEA-regulation of chondrocyte differentiation-
GO:0042474IEA-middle ear morphogenesis-
GO:0045596IEA-negative regulation of cell differentiation-
GO:0045944IEA-positive regulation of transcription from RNA polymerase II promoter-
GO:0048557ISS-embryonic digestive tract morphogenesis-
GO:0048701IEA-embryonic cranial skeleton morphogenesis-
GO:0072006ISS-nephron development-
GO:0072028ISS-nephron morphogenesis-
GO:0072038ISS-mesenchymal stem cell maintenance involved in nephron morphogenesis-
GO:0072137IEA-condensed mesenchymal cell proliferation-
GO:0072161ISS-mesenchymal cell differentiation involved in kidney development-
GO:0090189ISS-regulation of branching involved in ureteric bud morphogenesis-
GO:0097168ISS-mesenchymal stem cell proliferation-
GO:1902732ISS-positive regulation of chondrocyte proliferation-
Protein-Protein Interaction Top
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:102778
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-010412-1'