Gene Symbol:	MAP3K2 ( MEKK2,MEKK2B )
Gene Full Name:	mitogen-activated protein kinase kinase kinase 2
Band:	2q14.3
Quick Links	Entrez ID:10746; OMIM: 609487; Uniprot ID:M3K2_HUMAN; ENSEMBL ID: ENSG00000169967; HGNC ID: 6854
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0005654	IDA	-	nucleoplasm	-
GO:0005737	IBA	-	cytoplasm	-
GO:0005829	IDA	-	cytosol	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0004672	IDA	-	protein kinase activity	15001576
GO:0004674	TAS	-	protein serine/threonine kinase activity	8621389
GO:0004702	IBA	-	signal transducer, downstream of receptor, with serine/threonine kinase activity	-
GO:0004709	IEA	-	MAP kinase kinase kinase activity	-
GO:0005515	IPI	-	protein binding	15778465
GO:0005524	IEA	-	ATP binding	-
GO:0019901	IPI	-	protein kinase binding	17906693
GO:0046872	IEA	-	metal ion binding	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0000186	IEA	-	activation of MAPKK activity	-
GO:0000187	TAS	-	activation of MAPK activity	8621389
GO:0006468	TAS	-	protein phosphorylation	8621389
GO:0007257	TAS	-	activation of JUN kinase activity	8621389
GO:0030036	IBA	-	actin cytoskeleton organization	-
GO:0045893	IDA	-	positive regulation of transcription, DNA-templated	14515274
GO:0071260	IEP	-	cellular response to mechanical stimulus	19593445

Gene Symbol	Interactant	Interaction ID	References	Description
MAP3K2	XIAP	115969	18761086	Affinity Capture-Western; Biochemical Activity
MAP3K2	XIAP	106828	18761086	Affinity Capture-Western; Biochemical Activity
MAP3K2	SFN	115969	15778465	Affinity Capture-MS
MAP3K2	SFN	109072	15778465	Affinity Capture-MS
MAP3K2	MAPK8	115969	10713157	Affinity Capture-Western; Co-fractionation
MAP3K2	MAPK8	111585	10713157	Affinity Capture-Western; Co-fractionation
MAP3K2	MAP2K5	115969	11073940	Affinity Capture-Western; Two-hybrid
MAP3K2	MAP2K5	111593	11073940	Affinity Capture-Western; Two-hybrid
MAP3K2	MAP2K7	115969	10713157	Affinity Capture-Western; Co-fractionation
MAP3K2	MAP2K7	111595	10713157	Affinity Capture-Western; Co-fractionation
MAP3K2	MAP2K4	115969	10713157	Affinity Capture-Western
MAP3K2	MAP2K4	112315	10713157	Affinity Capture-Western
MAP3K2	YWHAE	115969	9452471	Reconstituted Complex
MAP3K2	YWHAE	113363	9452471	Reconstituted Complex
MAP3K2	IKBKG	115969	20098747	Reconstituted Complex
MAP3K2	IKBKG	114089	20098747	Reconstituted Complex
MAP3K2	SH2D2A	115969	11073940	Affinity Capture-Western; Two-hybrid
MAP3K2	SH2D2A	114509	11073940	Affinity Capture-Western; Two-hybrid
MAP3K2	PIBF1	115969	20936779	Two-hybrid
MAP3K2	PIBF1	115727	20936779	Two-hybrid

AutismKB 2.0

Annotation Details for MAP3K2