AutismKB 2.0

Annotation Details for CPLX1


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Basic Information Top
Gene Symbol:CPLX1 ( CPX-I,CPX1 )
Gene Full Name: complexin 1
Band: 4p16.3
Quick LinksEntrez ID:10815; OMIM: 605032; Uniprot ID:CPLX1_HUMAN; ENSEMBL ID: ENSG00000168993; HGNC ID: 2309
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005829TAS-cytosol-
GO:0030425IEA-dendrite-
GO:0043025IEA-neuronal cell body-
GO:0043195IEA-terminal bouton-
GO:0070032IEA-synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex-
GO:0070554TAS-synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex15217342
GO ID Evidence Qualifier GO_term References
GO:0005326IEA-neurotransmitter transporter activity-
GO:0017075IEA-syntaxin-1 binding-
GO ID Evidence Qualifier GO_term References
GO:0006887TAS-exocytosis7553862
GO:0007268TAS-chemical synaptic transmission7553862
GO:0007269TAS-neurotransmitter secretion-
GO:0014047TAS-glutamate secretion-
GO:0016079IEA-synaptic vesicle exocytosis-
GO:0017157TAS-regulation of exocytosis15217342
GO:0030073IEA-insulin secretion-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CPLX1SNAP2511602811832227 12200427 Co-crystal Structure; Reconstituted Complex
CPLX1SNAP2511250011832227 12200427 Co-crystal Structure; Reconstituted Complex
CPLX1STX1A11267610449403 11832227 12200427 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
CPLX1STX1A11602810449403 11832227 12200427 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
CPLX1VAMP211602811832227 Co-crystal Structure
CPLX1VAMP211271111832227 Co-crystal Structure
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
CPLX1C1884990, rs1052595, rs11722977, rs1314679, rs2276906, rs2306251, rs4690313, rs7677766, rs936551 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:104727
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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