AutismKB 2.0

Annotation Details for KIF2C


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Basic Information Top
Gene Symbol:KIF2C ( KNSL6,MCAK )
Gene Full Name: kinesin family member 2C
Band: 1p34.1
Quick LinksEntrez ID:11004; OMIM: 604538; Uniprot ID:KIF2C_HUMAN; ENSEMBL ID: ENSG00000142945; HGNC ID: 6393
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000775IDA-chromosome, centromeric region14960279
GO:0000776IDA-kinetochore23891108
GO:0000776IDAcolocalizes_withkinetochore14960279
GO:0000777IEA-condensed chromosome kinetochore-
GO:0005654IDA-nucleoplasm-
GO:0005813IDA-centrosome-
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0005871TAS-kinesin complex9434124
GO:0005881ISScolocalizes_withcytoplasmic microtubule-
GO:0015630IDA-microtubule cytoskeleton-
GO:0016020IDA-membrane19946888
GO:0035371IDA-microtubule plus-end21820309
GO ID Evidence Qualifier GO_term References
GO:0003777IBA-microtubule motor activity-
GO:0005515IPI-protein binding11092768
GO:0005524IEA-ATP binding-
GO:0016887IBA-ATPase activity-
GO:0019237TAS-centromeric DNA binding9434124
GO:0051010IDA-microtubule plus-end binding19632184
GO ID Evidence Qualifier GO_term References
GO:0000278TAS-mitotic cell cycle9434124
GO:0006890TAS-retrograde vesicle-mediated transport, Golgi to ER-
GO:0007018IBA-microtubule-based movement-
GO:0007018TAS-microtubule-based movement-
GO:0007019IDA-microtubule depolymerization21820309
GO:0007019IMP-microtubule depolymerization19060894
GO:0007062TAS-sister chromatid cohesion-
GO:0007080IMP-mitotic metaphase plate congression15843429
GO:0008283TAS-cell proliferation9434124
GO:0019886TAS-antigen processing and presentation of exogenous peptide antigen via MHC class II-
GO:0030951IMP-establishment or maintenance of microtubule cytoskeleton polarity14718566
GO:0051301IEA-cell division-
GO:0051310IMP-metaphase plate congression23891108
GO:0051315IMP-attachment of mitotic spindle microtubules to kinetochore23891108
GO:0051983IMP-regulation of chromosome segregation19060894
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
KIF2CAURKA11266618434591 Biochemical Activity
KIF2CAURKA11619518434591 Biochemical Activity
CENPHKIF2C12235511092768 Reconstituted Complex
CENPHKIF2C11619511092768 Reconstituted Complex
KIF2CKIF2C11619511466324 Affinity Capture-Western; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
No data
Gene Symbol Poly Names Gene overview in PDGene
KIF2Crs12732939 Gene overview in PDGene
No data
Animal Model Top
  • MGI ID: MGI:1921054
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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