AutismKB 2.0

Annotation Details for TLK2


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Basic Information Top
Gene Symbol:TLK2 ( MGC44450,PKU-ALPHA )
Gene Full Name: tousled-like kinase 2
Band: 17q23
Quick LinksEntrez ID:11011; OMIM: 608439; Uniprot ID:TLK2_HUMAN; ENSEMBL ID: ENSG00000146872; HGNC ID: 11842
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus9427565
GO:0005882IDA-intermediate filament10455159
GO:0048471IDA-perinuclear region of cytoplasm10455159
GO ID Evidence Qualifier GO_term References
GO:0004674IDA-protein serine/threonine kinase activity12660173
GO:0005515IPI-protein binding21903422
GO:0005524IDA-ATP binding12660173
GO ID Evidence Qualifier GO_term References
GO:0001672IDA-regulation of chromatin assembly or disassembly12660173
GO:0006468IDA-protein phosphorylation12660173
GO:0006974IDA-cellular response to DNA damage stimulus12660173
GO:0007049IEA-cell cycle-
GO:0007059IMP-chromosome segregation20705056
GO:0010507NAS-negative regulation of autophagy22354037
GO:0016569IEA-covalent chromatin modification-
GO:0018105IDA-peptidyl-serine phosphorylation20016786
GO:0032435IMP-negative regulation of proteasomal ubiquitin-dependent protein catabolic process20016786
GO:0035556IDA-intracellular signal transduction12660173
GO:0071480IDA-cellular response to gamma radiation12660173
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TLK2AURKA11266617940067 Affinity Capture-Western; Biochemical Activity
TLK2AURKA11620117940067 Affinity Capture-Western; Biochemical Activity
TLK2FEZ211499616484223 Two-hybrid
TLK2FEZ211620116484223 Two-hybrid
TLK2FEZ111499716484223 Two-hybrid
TLK2FEZ111620116484223 Two-hybrid
TLK2TLK111620110523312 Affinity Capture-Western
TLK2TLK111520610523312 Affinity Capture-Western
ASF1BTLK212084511470414 17353931 17940067 Affinity Capture-MS; Biochemical Activity; Two-hybrid
ASF1BTLK211620111470414 17353931 17940067 Affinity Capture-MS; Biochemical Activity; Two-hybrid
ASF1ATLK211736811470414 Biochemical Activity; Two-hybrid
ASF1ATLK211620111470414 Biochemical Activity; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1346023
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-060623-36'