AutismKB 2.0

Annotation Details for RIPK3


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Basic Information Top
Gene Symbol:RIPK3 ( RIP3 )
Gene Full Name: receptor-interacting serine-threonine kinase 3
Band: 14q12
Quick LinksEntrez ID:11035; OMIM: 605817; Uniprot ID:RIPK3_HUMAN; ENSEMBL ID: ENSG00000129465; HGNC ID: 10021
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005739IEA-mitochondrion-
GO:0005829IDA-cytosol22265413
GO:0005829TAS-cytosol-
GO:0005886IEA-plasma membrane-
GO:0097342IEA-ripoptosome-
GO ID Evidence Qualifier GO_term References
GO:0003713TAS-transcription coactivator activity10339433
GO:0004672IDA-protein kinase activity22265413
GO:0004672IMP-protein kinase activity22265414
GO:0004674ISS-protein serine/threonine kinase activity-
GO:0004674TAS-protein serine/threonine kinase activity-
GO:0004704IEA-NF-kappaB-inducing kinase activity-
GO:0005515IPI-protein binding19524512
GO:0005524IEA-ATP binding-
GO:0032403IMP-protein complex binding22265414
GO:0042802IPI-identical protein binding22817896
GO ID Evidence Qualifier GO_term References
GO:0001914ISS-regulation of T cell mediated cytotoxicity-
GO:0002819ISS-regulation of adaptive immune response-
GO:0006464TAS-cellular protein modification process10358032
GO:0007165TAS-signal transduction10339433
GO:0007249IEA-I-kappaB kinase/NF-kappaB signaling-
GO:0010922IMP-positive regulation of phosphatase activity22265414
GO:0032147IMP-activation of protein kinase activity22817896
GO:0032649ISS-regulation of interferon-gamma production-
GO:0033077ISS-T cell differentiation in thymus-
GO:0038061IEA-NIK/NF-kappaB signaling-
GO:0043029ISS-T cell homeostasis-
GO:0046006ISS-regulation of activated T cell proliferation-
GO:0046777IDA-protein autophosphorylation22265414
GO:0048535ISS-lymph node development-
GO:0048536ISS-spleen development-
GO:0048538ISS-thymus development-
GO:0051092IDA-positive regulation of NF-kappaB transcription factor activity21931591
GO:0051260IDA-protein homooligomerization22817896
GO:0051291IMP-protein heterooligomerization22817896
GO:0051351IEA-positive regulation of ligase activity-
GO:0051353IEA-positive regulation of oxidoreductase activity-
GO:0060545IDA-positive regulation of necroptotic process22265414
GO:0060545IMP-positive regulation of necroptotic process22817896
GO:0070235ISS-regulation of activation-induced cell death of T cells-
GO:0070266IMP-necroptotic process21737330
GO:0070266TAS-necroptotic process-
GO:0090312IEA-positive regulation of protein deacetylation-
GO:0097190TAS-apoptotic signaling pathway10339433
GO:1990000IMP-amyloid fibril formation22817896
GO:2000379IEA-positive regulation of reactive oxygen species metabolic process-
GO:2000452ISS-regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation-
GO:2001244IEA-positive regulation of intrinsic apoptotic signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
RIPK3TNFRSF1A11622410339433 Affinity Capture-Western
RIPK3TNFRSF1A11298610339433 Affinity Capture-Western
RIPK3TRAF211622410339433 Affinity Capture-Western
RIPK3TRAF211303810339433 Affinity Capture-Western
RIPK3RIPK111427410339433 Affinity Capture-Western; Two-hybrid
RIPK3RIPK111622410339433 Affinity Capture-Western; Two-hybrid
TICAM1RIPK311622415064760 Affinity Capture-Western
TICAM1RIPK312711415064760 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2154952
  • Data Attributes: HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-071115-4'