AutismKB 2.0

Annotation Details for WWP2


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Basic Information Top
Gene Symbol:WWP2 ( AIP2,WWp2-like )
Gene Full Name: WW domain containing E3 ubiquitin protein ligase 2
Band: 16q22.1
Quick LinksEntrez ID:11060; OMIM: 602308; Uniprot ID:WWP2_HUMAN; ENSEMBL ID: ENSG00000198373; HGNC ID: 16804
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000151TAS-ubiquitin ligase complex9647693
GO:0005634IDA-nucleus19274063
GO:0005737ISS-cytoplasm15047715
GO:0016020IDA-membrane19946888
GO:0070062IDA-extracellular exosome23533145
GO ID Evidence Qualifier GO_term References
GO:0001085IPI-RNA polymerase II transcription factor binding19274063
GO:0001085ISS-RNA polymerase II transcription factor binding15047715
GO:0001190IEA-transcriptional activator activity, RNA polymerase II transcription factor binding-
GO:0004842IDA-ubiquitin-protein transferase activity19274063
GO:0004842IMP-ubiquitin-protein transferase activity18776082
GO:0005515IPI-protein binding9647693
GO:0008134IPI-transcription factor binding19651900
GO:0061630IEA-ubiquitin protein ligase activity-
GO ID Evidence Qualifier GO_term References
GO:0000122IMP-negative regulation of transcription from RNA polymerase II promoter19274063
GO:0000122ISS-negative regulation of transcription from RNA polymerase II promoter15047715
GO:0006366IEA-transcription from RNA polymerase II promoter-
GO:0006464TAS-cellular protein modification process9169421
GO:0010629IMP-negative regulation of gene expression18776082
GO:0016567IDA-protein ubiquitination18776082
GO:0032410IDA-negative regulation of transporter activity18776082
GO:0034765IDA-regulation of ion transmembrane transport17289006
GO:0042391IDA-regulation of membrane potential17289006
GO:0043161IMP-proteasome-mediated ubiquitin-dependent protein catabolic process19274063
GO:0043433ISS-negative regulation of sequence-specific DNA binding transcription factor activity15047715
GO:0045892ISS-negative regulation of transcription, DNA-templated15047715
GO:0045944IEA-positive regulation of transcription from RNA polymerase II promoter-
GO:0046718TAS-viral entry into host cell12450395
GO:0051224IMP-negative regulation of protein transport18776082
GO:0051865IDA-protein autoubiquitination24105792
GO:0070534ISS-protein K63-linked ubiquitination-
GO:1901016IDA-regulation of potassium ion transmembrane transporter activity17289006
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
WWP2ATN11162449647693 Reconstituted Complex; Two-hybrid
WWP2ATN11081569647693 Reconstituted Complex; Two-hybrid
WWP2EWSR110843116189514 Two-hybrid
WWP2EWSR111624416189514 Two-hybrid
WWP2SCNN1A11224112167593 Reconstituted Complex
WWP2SCNN1A11624412167593 Reconstituted Complex
WWP2SCNN1B11224211244092 12167593 Far Western; Reconstituted Complex
WWP2SCNN1B11624411244092 12167593 Far Western; Reconstituted Complex
WWP2SCNN1G11224412167593 Reconstituted Complex
WWP2SCNN1G11624412167593 Reconstituted Complex
WWP2UBC11316417719543 Reconstituted Complex
WWP2UBC11624417719543 Reconstituted Complex
WWP2UBE2L311318017719543 Reconstituted Complex
WWP2UBE2L311624417719543 Reconstituted Complex
WWP2VASP11325116189514 Two-hybrid
WWP2VASP11624416189514 Two-hybrid
WWP2SF111336816189514 Two-hybrid
WWP2SF111624416189514 Two-hybrid
WWP2PDLIM711468216189514 Two-hybrid
WWP2PDLIM711624416189514 Two-hybrid
WWP2SCAMP311624419158374 Two-hybrid
WWP2SCAMP311537819158374 Two-hybrid
WWP2CPSF611624416189514 Two-hybrid
WWP2CPSF611623816189514 Two-hybrid
WBP2WWP21162449169421 Protein-peptide
WBP2WWP21171029169421 Protein-peptide
WBP1WWP21171039169421 Protein-peptide
WBP1WWP21162449169421 Protein-peptide
DIDO1WWP211624416189514 Two-hybrid
DIDO1WWP211626616189514 Two-hybrid
Gene Symbol Interactant Interaction ID References Description
WWP2ATN12090229647693 Atrophin-1 interacts with AIP2.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1914144
  • Data Attributes: MGI curated and HomoloGene calculated
No data