Annotation Details for RAPGEF4

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Basic Information Top

Gene Symbol:	RAPGEF4 ( CAMP-GEFII,CGEF2,EPAC2,Nbla00496 )
Gene Full Name:	Rap guanine nucleotide exchange factor (GEF) 4
Band:	2q31.1
Quick Links	Entrez ID:11069; OMIM: 606058; Uniprot ID:RPGF4_HUMAN; ENSEMBL ID: ENSG00000091428; HGNC ID: 16626
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

AlzGene, PDGene and SZGene

Gene Ontology

Cellular Component:3 results
Molecular Function:5 results
Biological Process:8 results

GO ID	Evidence	Qualifier	GO_term	References
GO:0005829	IEA	-	cytosol	-
GO:0005886	TAS	-	plasma membrane	-
GO:0016020	TAS	-	membrane	10777494

GO ID	Evidence	Qualifier	GO_term	References
GO:0005085	EXP	-	guanyl-nucleotide exchange factor activity	15334074
GO:0005088	ISS	-	Ras guanyl-nucleotide exchange factor activity	-
GO:0005515	IPI	-	protein binding	11438518
GO:0017016	ISS	-	Ras GTPase binding	-
GO:0030552	ISS	-	cAMP binding	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0007186	TAS	-	G-protein coupled receptor signaling pathway	9856955
GO:0007264	IEA	-	small GTPase mediated signal transduction	-
GO:0017156	IEA	-	calcium ion regulated exocytosis	-
GO:0017157	IEA	-	regulation of exocytosis	-
GO:0019933	IEA	-	cAMP-mediated signaling	-
GO:0030073	IEA	-	insulin secretion	-
GO:0043547	IEA	-	positive regulation of GTPase activity	-
GO:0050796	TAS	-	regulation of insulin secretion	-

Protein-Protein Interaction

BioGRID:8 results
BIND:0 results
HPRD:0 results

Gene Symbol	Interactant	Interaction ID	References	Description
RAPGEF4	RAP1A	116253	10777494	Biochemical Activity
RAPGEF4	RAP1A	111841	10777494	Biochemical Activity
RAPGEF4	RAP2A	116253	10777494	Biochemical Activity
RAPGEF4	RAP2A	111846	10777494	Biochemical Activity
RAPGEF4	ABCC8	116253	14660679	Affinity Capture-Western
RAPGEF4	ABCC8	112700	14660679	Affinity Capture-Western
RAPGEF4	RIMS2	116253	11598134 14660679	Affinity Capture-Western
RAPGEF4	RIMS2	115051	11598134 14660679	Affinity Capture-Western

AlzGene, PDGene and SZGene

Animal Model

Mouse:1 results
Fruit Fly:0 results

MGI ID: MGI:1917723
Data Attributes: MGI curated and HomoloGene calculated

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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