AutismKB 2.0

Annotation Details for CHD3


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Basic Information Top
Gene Symbol:CHD3 ( Mi-2a,Mi2-ALPHA,ZFH )
Gene Full Name: chromodomain helicase DNA binding protein 3
Band: 17p13.1
Quick LinksEntrez ID:1107; OMIM: 602120; Uniprot ID:CHD3_HUMAN; ENSEMBL ID: ENSG00000170004; HGNC ID: 1918
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus22720776
GO:0005634NAS-nucleus9688266
GO:0005654TAS-nucleoplasm-
GO:0005730IDA-nucleolus-
GO:0005737IDA-cytoplasm17626165
GO:0005813IDA-centrosome17626165
GO:0005815IDA-microtubule organizing center-
GO:0016581IDA-NuRD complex17827154
GO ID Evidence Qualifier GO_term References
GO:0003677IEA-DNA binding-
GO:0003723IDA-RNA binding22658674
GO:0004003TAS-ATP-dependent DNA helicase activity9326634
GO:0004386NAS-helicase activity9688266
GO:0004407TAS-histone deacetylase activity-
GO:0005515IPI-protein binding9804427
GO:0005524IEA-ATP binding-
GO:0008270NAS-zinc ion binding9688266
GO ID Evidence Qualifier GO_term References
GO:0006333IEA-chromatin assembly or disassembly-
GO:0006351IEA-transcription, DNA-templated-
GO:0006355NAS-regulation of transcription, DNA-templated9688266
GO:0006357TAS-regulation of transcription from RNA polymerase II promoter9326634
GO:0007051IDA-spindle organization17626165
GO:0007098IDA-centrosome cycle17626165
GO:0016575IEA-histone deacetylation-
GO:0032508IEA-DNA duplex unwinding-
GO:1901796TAS-regulation of signal transduction by p53 class mediator-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CHD3ADH510753216169070 Two-hybrid
CHD3ADH510664016169070 Two-hybrid
CHD3BCL610707615454082 Affinity Capture-Western; Reconstituted Complex
CHD3BCL610753215454082 Affinity Capture-Western; Reconstituted Complex
CHD3CASP610753216169070 Two-hybrid
CHD3CASP610728916169070 Two-hybrid
CHD3CASP810753216169070 Two-hybrid
CHD3CASP810729116169070 Two-hybrid
HDAC2CHD31075329804427 12198550 12493763 17827154 Affinity Capture-MS; Affinity Capture-Western; Co-purification
HDAC2CHD31093169804427 12198550 12493763 17827154 Affinity Capture-MS; Affinity Capture-Western; Co-purification
HDAC1CHD31075329804427 11784859 17827154 Affinity Capture-Western
HDAC1CHD31093159804427 11784859 17827154 Affinity Capture-Western
MTA2CHD310753210444591 11297506 Affinity Capture-Western; Co-purification
MTA2CHD311465210444591 11297506 Affinity Capture-Western; Co-purification
MBD2CHD310753210444591 11297506 Affinity Capture-Western; Reconstituted Complex
MBD2CHD311444510444591 11297506 Affinity Capture-Western; Reconstituted Complex
TP53CHD311301010961991 Two-hybrid
TP53CHD310753210961991 Two-hybrid
TP73CHD311301410961991 Two-hybrid
TP73CHD310753210961991 Two-hybrid
SUMO1CHD310753210961991 Two-hybrid
SUMO1CHD311318810961991 Two-hybrid
HIST1H3ACHD311394611850410 16728976 Affinity Capture-MS
HIST1H3ACHD310753211850410 16728976 Affinity Capture-MS
RAD21CHD311182212198550 Co-purification
RAD21CHD310753212198550 Co-purification
SMARCA5CHD310753212198550 Co-purification
SMARCA5CHD311404512198550 Co-purification
MTA1CHD311456212431981 17922035 Affinity Capture-Western
MTA1CHD310753212431981 17922035 Affinity Capture-Western
ALL1CHD310753212453419 Affinity Capture-Western
ALL1CHD3114743012453419 Affinity Capture-Western
SIN3ACHD311743912453419 Affinity Capture-Western
SIN3ACHD310753212453419 Affinity Capture-Western
SMARCA2CHD310753212453419 Affinity Capture-Western
SMARCA2CHD311247912453419 Affinity Capture-Western
TAF6CHD311274112453419 Affinity Capture-Western
TAF6CHD310753212453419 Affinity Capture-Western
HABP4CHD311658712505151 16169070 16455055 Reconstituted Complex; Two-hybrid
HABP4CHD310753212505151 16169070 16455055 Reconstituted Complex; Two-hybrid
SERBP1CHD311757112505151 16169070 Reconstituted Complex; Two-hybrid
SERBP1CHD310753212505151 16169070 Reconstituted Complex; Two-hybrid
MTA3CHD312156812705869 Affinity Capture-Western
MTA3CHD310753212705869 Affinity Capture-Western
UBE2ICHD310753214609633 Two-hybrid
UBE2ICHD311317714609633 Two-hybrid
MBD3L1CHD312456915456747 Affinity Capture-Western
MBD3L1CHD310753215456747 Affinity Capture-Western
TRIM28CHD311545716169070 Two-hybrid
TRIM28CHD310753216169070 Two-hybrid
SERF2CHD310753216169070 Two-hybrid
SERF2CHD311547116169070 Two-hybrid
TXNDC9CHD311548716169070 Two-hybrid
TXNDC9CHD310753216169070 Two-hybrid
PAICSCHD311585216169070 Two-hybrid
PAICSCHD310753216169070 Two-hybrid
IVNS1ABPCHD311586916169070 Two-hybrid
IVNS1ABPCHD310753216169070 Two-hybrid
SDCCAG3CHD311602116169070 Two-hybrid
SDCCAG3CHD310753216169070 Two-hybrid
HSPH1CHD311602216169070 Two-hybrid
HSPH1CHD310753216169070 Two-hybrid
IMMTCHD311618516169070 Two-hybrid
IMMTCHD310753216169070 Two-hybrid
CPECHD310775516169070 Two-hybrid
CPECHD310753216169070 Two-hybrid
CREB1CHD310753216169070 Two-hybrid
CREB1CHD310777516169070 Two-hybrid
CSTF2CHD310753216169070 Two-hybrid
CSTF2CHD310786016169070 Two-hybrid
CTTNCHD310753216169070 Two-hybrid
CTTNCHD310833216169070 Two-hybrid
PUF60CHD311650216169070 Two-hybrid
PUF60CHD310753216169070 Two-hybrid
GPS2CHD310753216169070 Two-hybrid
GPS2CHD310913216169070 Two-hybrid
SLC27A6CHD311879016169070 Two-hybrid
SLC27A6CHD310753216169070 Two-hybrid
IKCHD310976616169070 Two-hybrid
IKCHD310753216169070 Two-hybrid
MAFGCHD310753216169070 Two-hybrid
MAFGCHD311027216169070 Two-hybrid
MAN2A2CHD311029516169070 Two-hybrid
MAN2A2CHD310753216169070 Two-hybrid
PCMT1CHD311114116169070 Two-hybrid
PCMT1CHD310753216169070 Two-hybrid
SIRT6CHD311960316169070 Two-hybrid
SIRT6CHD310753216169070 Two-hybrid
SRRTCHD311962616169070 Two-hybrid
SRRTCHD310753216169070 Two-hybrid
LUC7L2CHD311964616169070 Two-hybrid
LUC7L2CHD310753216169070 Two-hybrid
CRCT1CHD312003116169070 Two-hybrid
CRCT1CHD310753216169070 Two-hybrid
PRG2CHD311154416169070 Two-hybrid
PRG2CHD310753216169070 Two-hybrid
KIF15CHD312130716169070 Two-hybrid
KIF15CHD310753216169070 Two-hybrid
C7orf36CHD312131716169070 Two-hybrid
C7orf36CHD310753216169070 Two-hybrid
PSME1CHD310753216169070 Two-hybrid
PSME1CHD311169216169070 Two-hybrid
PTNCHD310753216169070 Two-hybrid
PTNCHD311173116169070 Two-hybrid
PTPRSCHD310753216169070 Two-hybrid
PTPRSCHD311176616169070 Two-hybrid
RAD51CHD310753216169070 Two-hybrid
RAD51CHD311182516169070 Two-hybrid
RPL29CHD310753216169070 Two-hybrid
RPL29CHD311207816169070 Two-hybrid
SAFBCHD311220116169070 Two-hybrid
SAFBCHD310753216169070 Two-hybrid
SAT1CHD311221016169070 Two-hybrid
SAT1CHD310753216169070 Two-hybrid
SUMO2CHD310753216169070 Two-hybrid
SUMO2CHD311249716169070 Two-hybrid
TSPAN6CHD310753216169070 Two-hybrid
TSPAN6CHD311296016169070 Two-hybrid
TTRCHD311312716169070 Two-hybrid
TTRCHD310753216169070 Two-hybrid
XRCC4CHD310753216169070 Two-hybrid
XRCC4CHD311335216169070 Two-hybrid
FAM134ACHD312255816169070 Two-hybrid
FAM134ACHD310753216169070 Two-hybrid
THOC7CHD310753216169070 Two-hybrid
THOC7CHD312313816169070 Two-hybrid
C4orf17CHD312389216169070 Two-hybrid
C4orf17CHD310753216169070 Two-hybrid
BHLHE40CHD310753216169070 Two-hybrid
BHLHE40CHD311412316169070 Two-hybrid
TNFRSF14CHD310753216169070 Two-hybrid
TNFRSF14CHD311429816169070 Two-hybrid
FBP2CHD310753216169070 Two-hybrid
FBP2CHD311431716169070 Two-hybrid
FUBP1CHD311439916169070 Two-hybrid
FUBP1CHD310753216169070 Two-hybrid
UBA3CHD310753216169070 Two-hybrid
UBA3CHD311450316169070 Two-hybrid
ATPIF1CHD312506316169070 Two-hybrid
ATPIF1CHD310753216169070 Two-hybrid
SGSM2CHD311523416169070 Two-hybrid
SGSM2CHD310753216169070 Two-hybrid
NAB2CHD310753216574654 Affinity Capture-Western
NAB2CHD311074716574654 Affinity Capture-Western
CHD6CHD312393117027977 Co-fractionation
CHD6CHD310753217027977 Co-fractionation
PCNTCHD311114617626165 Affinity Capture-Western; Two-hybrid
PCNTCHD310753217626165 Affinity Capture-Western; Two-hybrid
CSNK2A1CHD310753217827154 Affinity Capture-Western
CSNK2A1CHD310784117827154 Affinity Capture-Western
HSF1CHD310753217922035 Affinity Capture-Western
HSF1CHD310953017922035 Affinity Capture-Western
Gene Symbol Interactant Interaction ID References Description
CHD3BCL618037915454082 BCL6 interacts with Mi2.
UBE2ICHD314551414609633 Ubc9 interacts with CHD3.
SUMO1CHD35814314609633 SUMO-1 interacts with CHD3.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1344395
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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