AutismKB 2.0

Annotation Details for TOPBP1


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Basic Information Top
Gene Symbol:TOPBP1 ( TOP2BP1 )
Gene Full Name: topoisomerase (DNA) II binding protein 1
Band: 3q22.1
Quick LinksEntrez ID:11073; OMIM: 607760; Uniprot ID:TOPB1_HUMAN; ENSEMBL ID: ENSG00000163781; HGNC ID: 17008
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000794IEA-condensed nuclear chromosome-
GO:0000922IEA-spindle pole-
GO:0001673IEA-male germ cell nucleus-
GO:0005634IDA-nucleus-
GO:0005654TAS-nucleoplasm-
GO:0005694IDA-chromosome21659603
GO:0005737IEA-cytoplasm-
GO:0005815IEA-microtubule organizing center-
GO:0015629IDA-actin cytoskeleton-
GO:0016604IDA-nuclear body-
GO:0016605IDA-PML body12773567
GO ID Evidence Qualifier GO_term References
GO:0003677IEA-DNA binding-
GO:0005515IPI-protein binding12773567
GO:0008022TAS-protein C-terminus binding9461304
GO:0042802IPI-identical protein binding17006541
GO ID Evidence Qualifier GO_term References
GO:0006259TAS-DNA metabolic process9461304
GO:0006260TAS-DNA replication-
GO:0006270IBA-DNA replication initiation-
GO:0006281NAS-DNA repair12773567
GO:0006974IDA-cellular response to DNA damage stimulus12773567
GO:0007095IBA-mitotic G2 DNA damage checkpoint-
GO:0010212IDA-response to ionizing radiation12773567
GO:0033314IBA-mitotic DNA replication checkpoint-
GO:1901796TAS-regulation of signal transduction by p53 class mediator-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TOPBP1ABL111625615961388 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
TOPBP1ABL110654315961388 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
TOPBP1ATR11625619097996 Affinity Capture-Western
TOPBP1ATR10702719097996 Affinity Capture-Western
TOPBP1CALCR11625618923429 Affinity Capture-Western
TOPBP1CALCR10725018923429 Affinity Capture-Western
TOPBP1CLK211625619097996 Affinity Capture-Western
TOPBP1CLK210760719097996 Affinity Capture-Western
TOPBP1E2F111625612697828 14576433 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TOPBP1E2F110820112697828 14576433 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TOPBP1MSH611625620029092 Affinity Capture-Western
TOPBP1MSH610921120029092 Affinity Capture-Western
TOPBP1PML11625612773567 Affinity Capture-Western
TOPBP1PML11138412773567 Affinity Capture-Western
TOPBP1PMS211625620029092 Affinity Capture-Western
TOPBP1PMS211140420029092 Affinity Capture-Western
TOPBP1POLE11625611395493 Affinity Capture-Western
TOPBP1POLE11142211395493 Affinity Capture-Western
TOPBP1RAD9A11182011395493 12941802 17575048 Affinity Capture-Western; Two-hybrid
TOPBP1RAD9A11625611395493 12941802 17575048 Affinity Capture-Western; Two-hybrid
TOPBP1RPA111625620159562 Co-localization
TOPBP1RPA111203720159562 Co-localization
TOPBP1TOP2B1162569461304 Two-hybrid
TOPBP1TOP2B1130089461304 Two-hybrid
TOPBP1ZBTB1711625612408820 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TOPBP1ZBTB1711350312408820 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
UBR5TOPBP111625611714696 Affinity Capture-Western; Biochemical Activity; Two-hybrid
UBR5TOPBP111950111714696 Affinity Capture-Western; Biochemical Activity; Two-hybrid
RPAP2TOPBP111625617643375 Affinity Capture-MS
RPAP2TOPBP112295917643375 Affinity Capture-MS
BRIP1TOPBP111625620159562 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BRIP1TOPBP112384120159562 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1920018
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-060626-1'