AutismKB 2.0

Annotation Details for CHD4


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Basic Information Top
Gene Symbol:CHD4 ( DKFZp686E06161,Mi-2b,Mi2-BETA )
Gene Full Name: chromodomain helicase DNA binding protein 4
Band: 12p13.31
Quick LinksEntrez ID:1108; OMIM: 603277; Uniprot ID:CHD4_HUMAN; ENSEMBL ID: ENSG00000111642; HGNC ID: 1919
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000790IDA-nuclear chromatin16217013
GO:0005634IDA-nucleus-
GO:0005654IDA-nucleoplasm22720776
GO:0005654TAS-nucleoplasm-
GO:0005737IDA-cytoplasm17626165
GO:0005813IDA-centrosome17626165
GO:0016020IDA-membrane19946888
GO:0016581IDA-NuRD complex19644445
GO:0032993IEA-protein-DNA complex-
GO:0043234IDA-protein complex16217013
GO ID Evidence Qualifier GO_term References
GO:0000978IDAcontributes_toRNA polymerase II core promoter proximal region sequence-specific DNA binding16217013
GO:0000980IDAcontributes_toRNA polymerase II distal enhancer sequence-specific DNA binding16217013
GO:0001103IPI-RNA polymerase II repressing transcription factor binding22926524
GO:0003677TAS-DNA binding9326634
GO:0004003TAS-ATP-dependent DNA helicase activity9326634
GO:0004407TAS-histone deacetylase activity-
GO:0005515IPI-protein binding9804427
GO:0005524IEA-ATP binding-
GO:0008017IEA-microtubule binding-
GO:0008270TAS-zinc ion binding7560064
GO:0031492IDAcontributes_tonucleosomal DNA binding16217013
GO:0042826IPI-histone deacetylase binding27616479
GO ID Evidence Qualifier GO_term References
GO:0000122IEA-negative regulation of transcription from RNA polymerase II promoter-
GO:0006351IEA-transcription, DNA-templated-
GO:0006357TAS-regulation of transcription from RNA polymerase II promoter9326634
GO:0016575IEA-histone deacetylation-
GO:0032508IEA-DNA duplex unwinding-
GO:0043044IDA-ATP-dependent chromatin remodeling16217013
GO:0051225IEA-spindle assembly-
GO:0072553IEA-terminal button organization-
GO:1901796TAS-regulation of signal transduction by p53 class mediator-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CHD4ATR10702710545197 Affinity Capture-MS; Affinity Capture-Western
CHD4ATR10753310545197 Affinity Capture-MS; Affinity Capture-Western
SIN3ACHD41174399790534 Affinity Capture-MS
SIN3ACHD41075339790534 Affinity Capture-MS
UBASH3BCHD41243909790534 Affinity Capture-MS
UBASH3BCHD41075339790534 Affinity Capture-MS
HDAC2CHD41093169790534 9804427 10545197 11003653 12493763 Affinity Capture-MS; Affinity Capture-Western
HDAC2CHD41075339790534 9804427 10545197 11003653 12493763 Affinity Capture-MS; Affinity Capture-Western
SAP30CHD41143469790534 Affinity Capture-MS; Affinity Capture-Western
SAP30CHD41075339790534 Affinity Capture-MS; Affinity Capture-Western
MTA2CHD41146529790534 12920132 Affinity Capture-MS; Affinity Capture-Western
MTA2CHD41075339790534 12920132 Affinity Capture-MS; Affinity Capture-Western
HDAC1CHD41093159790534 9804427 10220385 11102443 12920132 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
HDAC1CHD41075339790534 9804427 10220385 11102443 12920132 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
RBBP4CHD41118639790534 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
RBBP4CHD41075339790534 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
RBBP7CHD41118669790534 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
RBBP7CHD41075339790534 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
IKZF1CHD411560411003653 12015313 Affinity Capture-Western
IKZF1CHD410753311003653 12015313 Affinity Capture-Western
SMARCC1CHD410753311003653 16217013 Affinity Capture-Western
SMARCC1CHD411248311003653 16217013 Affinity Capture-Western
SMARCE1CHD411248911003653 Affinity Capture-Western
SMARCE1CHD410753311003653 Affinity Capture-Western
SMARCA4CHD411248111003653 14530259 16217013 Affinity Capture-Western; Two-hybrid
SMARCA4CHD410753311003653 14530259 16217013 Affinity Capture-Western; Two-hybrid
IKZF3CHD411648412015313 Affinity Capture-Western
IKZF3CHD410753312015313 Affinity Capture-Western
IKZF2CHD411648512015313 Affinity Capture-Western
IKZF2CHD410753312015313 Affinity Capture-Western
IKZF4CHD412214612015313 Affinity Capture-Western
IKZF4CHD410753312015313 Affinity Capture-Western
MBD3CHD411978812354758 Affinity Capture-Western
MBD3CHD410753312354758 Affinity Capture-Western
SATB1CHD411221112374985 Affinity Capture-Western; Co-fractionation
SATB1CHD410753312374985 Affinity Capture-Western; Co-fractionation
MTA1CHD411456212920132 Affinity Capture-MS
MTA1CHD410753312920132 Affinity Capture-MS
TRIM27CHD410753314530259 Affinity Capture-Western; Two-hybrid
TRIM27CHD411191914530259 Affinity Capture-Western; Two-hybrid
XRN1CHD411997015231747 Two-hybrid
XRN1CHD410753315231747 Two-hybrid
MBD3L2CHD412594415701600 Reconstituted Complex
MBD3L2CHD410753315701600 Reconstituted Complex
CBX5CHD411703015882967 Affinity Capture-MS
CBX5CHD410753315882967 Affinity Capture-MS
BCL11BCHD412234316091750 Affinity Capture-MS; Affinity Capture-Western
BCL11BCHD410753316091750 Affinity Capture-MS; Affinity Capture-Western
BCL11ACHD411973716091750 Affinity Capture-Western
BCL11ACHD410753316091750 Affinity Capture-Western
SRRM1CHD411554416159877 Affinity Capture-MS
SRRM1CHD410753316159877 Affinity Capture-MS
MCRS1CHD411571016186106 Affinity Capture-Western
MCRS1CHD410753316186106 Affinity Capture-Western
HNRNPCCHD410942416217013 Affinity Capture-Western
HNRNPCCHD410753316217013 Affinity Capture-Western
NAB1CHD411074616574654 Affinity Capture-Western
NAB1CHD410753316574654 Affinity Capture-Western
NAB2CHD411074716574654 Affinity Capture-Western
NAB2CHD410753316574654 Affinity Capture-Western
H3F3ACHD410753317403666 Affinity Capture-MS
H3F3ACHD410927217403666 Affinity Capture-MS
EMDCHD410832517620012 Affinity Capture-MS
EMDCHD410753317620012 Affinity Capture-MS
PCNTCHD411114617626165 Affinity Capture-Western; Two-hybrid
PCNTCHD410753317626165 Affinity Capture-Western; Two-hybrid
PMLCHD411138418644863 Affinity Capture-Western
PMLCHD410753318644863 Affinity Capture-Western
NR4A1CHD410940719321449 Affinity Capture-MS
NR4A1CHD410753319321449 Affinity Capture-MS
SUMO2CHD411249719394292 Affinity Capture-MS
SUMO2CHD410753319394292 Affinity Capture-MS
USP36CHD412165119615732 Affinity Capture-MS
USP36CHD410753319615732 Affinity Capture-MS
BANF1CHD411434219759913 Affinity Capture-MS
BANF1CHD410753319759913 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
CHD4rs1639122 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:1344380
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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