AutismKB 2.0

Annotation Details for POLR3A


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Basic Information Top
Gene Symbol:POLR3A ( RPC1,RPC155,hRPC155 )
Gene Full Name: polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
Band: 10q22.3
Quick LinksEntrez ID:11128; OMIM: NA; Uniprot ID:RPC1_HUMAN; ENSEMBL ID: ENSG00000148606; HGNC ID: 30074
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005666IDA-DNA-directed RNA polymerase III complex24107381
GO:0005829TAS-cytosol-
GO:0016020IDA-membrane19946888
GO ID Evidence Qualifier GO_term References
GO:0001056IBAcontributes_toRNA polymerase III activity-
GO:0003677IEA-DNA binding-
GO:0003682IEA-chromatin binding-
GO:0003899NAS-DNA-directed 5'-3' RNA polymerase activity9331371
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0006351NAS-transcription, DNA-templated9331371
GO:0006383IEA-transcription from RNA polymerase III promoter-
GO:0032481TAS-positive regulation of type I interferon production-
GO:0032728IMP-positive regulation of interferon-beta production19609254
GO:0045087IMP-innate immune response19609254
GO:0051607IEA-defense response to virus-
GO:1903146IMP-regulation of mitophagy24912190
GO:1903955IMP-positive regulation of protein targeting to mitochondrion24912190
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
POLR3APOLR3D10712912391170 Affinity Capture-MS
POLR3APOLR3D11630112391170 Affinity Capture-MS
POLR3AEWSR110843120211142 Two-hybrid
POLR3AEWSR111630120211142 Two-hybrid
POLR3AGTF2B10921411416169 Affinity Capture-Western
POLR3AGTF2B11630111416169 Affinity Capture-Western
POLR3ANEDD411081116055720 Affinity Capture-MS
POLR3ANEDD411630116055720 Affinity Capture-MS
POLR3APCBD111112520211142 Two-hybrid
POLR3APCBD111630120211142 Two-hybrid
POLR3APKP211133511416169 Affinity Capture-MS; Reconstituted Complex
POLR3APKP211630111416169 Affinity Capture-MS; Reconstituted Complex
POLR3ARAE111405419615732 Affinity Capture-MS
POLR3ARAE111630119615732 Affinity Capture-MS
POLR3AIKBKG11408920211142 Two-hybrid
POLR3AIKBKG11630120211142 Two-hybrid
POLR3EPOLR3A12084012391170 Affinity Capture-Western; Co-purification
POLR3EPOLR3A11630112391170 Affinity Capture-Western; Co-purification
GPN1POLR3A11630117643375 Affinity Capture-MS
GPN1POLR3A11645217643375 Affinity Capture-MS
POLR3HPOLR3A12814717643375 Affinity Capture-MS
POLR3HPOLR3A11630117643375 Affinity Capture-MS
RPAP1POLR3A11630117643375 Affinity Capture-MS
RPAP1POLR3A11748717643375 Affinity Capture-MS
RPAP3POLR3A11630117643375 Affinity Capture-MS
RPAP3POLR3A12278317643375 Affinity Capture-MS
RPAP2POLR3A11630117643375 Affinity Capture-MS
RPAP2POLR3A12295917643375 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2681836
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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