Annotation Details for LZTS1

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Basic Information Top

Gene Symbol:	LZTS1 ( F37,FEZ1 )
Gene Full Name:	leucine zipper, putative tumor suppressor 1
Band:	8p21.3
Quick Links	Entrez ID:11178; OMIM: 606551; Uniprot ID:LZTS1_HUMAN; ENSEMBL ID: ENSG00000061337; HGNC ID: 13861
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

AlzGene, PDGene and SZGene

Gene Ontology

Cellular Component:8 results
Molecular Function:4 results
Biological Process:6 results

GO ID	Evidence	Qualifier	GO_term	References
GO:0005737	IEA	-	cytoplasm	-
GO:0014069	IEA	-	postsynaptic density	-
GO:0016324	IEA	-	apical plasma membrane	-
GO:0030054	IEA	-	cell junction	-
GO:0043197	IEA	-	dendritic spine	-
GO:0043198	IEA	-	dendritic shaft	-
GO:0044297	IEA	-	cell body	-
GO:0045211	IEA	-	postsynaptic membrane	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0003677	NAS	-	DNA binding	10097140
GO:0003700	TAS	-	transcription factor activity, sequence-specific DNA binding	10097140
GO:0005515	IPI	-	protein binding	17349584
GO:0008017	IEA	-	microtubule binding	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0006351	NAS	-	transcription, DNA-templated	10097140
GO:0006355	IEA	-	regulation of transcription, DNA-templated	-
GO:0016242	IMP	-	negative regulation of macroautophagy	22354037
GO:0044772	IEA	-	mitotic cell cycle phase transition	-
GO:0048167	IEA	-	regulation of synaptic plasticity	-
GO:0048814	IEA	-	regulation of dendrite morphogenesis	-

Protein-Protein Interaction

BioGRID:4 results
BIND:0 results
HPRD:0 results

Gene Symbol	Interactant	Interaction ID	References	Description
LZTS1	CDK1	116348	11504921	Affinity Capture-Western
LZTS1	CDK1	107420	11504921	Affinity Capture-Western
LZTS1	EEF1G	116348	11504921	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
LZTS1	EEF1G	108257	11504921	Affinity Capture-Western; Reconstituted Complex; Two-hybrid

AlzGene, PDGene and SZGene

Animal Model

Mouse:1 results
Fruit Fly:0 results

MGI ID: MGI:2684762
Data Attributes: MGI curated and HomoloGene calculated

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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