AutismKB 2.0

Annotation Details for MAP4K1


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Basic Information Top
Gene Symbol:MAP4K1 ( HPK1 )
Gene Full Name: mitogen-activated protein kinase kinase kinase kinase 1
Band: 19q13.1-q13.4
Quick LinksEntrez ID:11184; OMIM: 601983; Uniprot ID:M4K1_HUMAN; ENSEMBL ID: ENSG00000104814; HGNC ID: 6863
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IBA-cytoplasm-
GO:0016020IDA-membrane19946888
GO ID Evidence Qualifier GO_term References
GO:0004672TAS-protein kinase activity8824585
GO:0004674IDA-protein serine/threonine kinase activity8824585
GO:0005515IPI-protein binding9346925
GO:0005524IDA-ATP binding8824585
GO:0008349IDA-MAP kinase kinase kinase kinase activity11053428
GO ID Evidence Qualifier GO_term References
GO:0000185IC-activation of MAPKKK activity11053428
GO:0006468IDA-protein phosphorylation8824585
GO:0006950IDA-response to stress8824585
GO:0007257TAS-activation of JUN kinase activity8824585
GO:0008283IMP-cell proliferation24362026
GO:0018105IDA-peptidyl-serine phosphorylation11053428
GO:0035556IDA-intracellular signal transduction8824585
GO:0046777IDA-protein autophosphorylation24362026
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MAP4K1CRK1163549788432 9891069 11279207 Affinity Capture-Western; Reconstituted Complex
MAP4K1CRK1077889788432 9891069 11279207 Affinity Capture-Western; Reconstituted Complex
MAP4K1CRKL1077899788432 9891069 11279207 Affinity Capture-Western; Reconstituted Complex
MAP4K1CRKL1163549788432 9891069 11279207 Affinity Capture-Western; Reconstituted Complex
MAP4K1EGFR1082769346925 Co-fractionation
MAP4K1EGFR1163549346925 Co-fractionation
MAP4K1GRB21091429346925 9788432 9891069 11279207 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MAP4K1GRB21163549346925 9788432 9891069 11279207 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MAP4K1HCLS111635410233887 Affinity Capture-Western
MAP4K1HCLS110930910233887 Affinity Capture-Western
MAP4K1MAP3K1111044211053428 Biochemical Activity
MAP4K1MAP3K1111635411053428 Biochemical Activity
MAP4K1NCK11107709346925 9891069 11279207 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MAP4K1NCK11163549346925 9891069 11279207 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MAP4K1PPP4C11152315364934 Affinity Capture-Western; Biochemical Activity
MAP4K1PPP4C11635415364934 Affinity Capture-Western; Biochemical Activity
MAP4K1MAP3K711274810224067 Affinity Capture-Western
MAP4K1MAP3K711635410224067 Affinity Capture-Western
MAP4K1UBC11316415364934 Affinity Capture-Western
MAP4K1UBC11635415364934 Affinity Capture-Western
MAP4K1GRAP211479911313918 Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid
MAP4K1GRAP211635411313918 Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid
DBNLMAP4K111880910567356 Affinity Capture-Western; Reconstituted Complex
DBNLMAP4K111635410567356 Affinity Capture-Western; Reconstituted Complex
LATMAP4K111635411279207 Affinity Capture-Western; Co-fractionation
LATMAP4K111797111279207 Affinity Capture-Western; Co-fractionation
BLNKMAP4K111889411514608 Affinity Capture-Western; Reconstituted Complex
BLNKMAP4K111635411514608 Affinity Capture-Western; Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1346882
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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