AutismKB 2.0

Annotation Details for RNF139


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Basic Information Top
Gene Symbol:RNF139 ( HRCA1,MGC31961,RCA1,TRC8 )
Gene Full Name: ring finger protein 139
Band: 8q24.13
Quick LinksEntrez ID:11236; OMIM: 603046; Uniprot ID:RN139_HUMAN; ENSEMBL ID: ENSG00000170881; HGNC ID: 17023
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005783IDA-endoplasmic reticulum12032852
GO:0005789TAS-endoplasmic reticulum membrane-
GO:0016021TAS-integral component of membrane12032852
GO:0036513IDA-Derlin-1 retrotranslocation complex25239945
GO:0044322IEA-endoplasmic reticulum quality control compartment-
GO ID Evidence Qualifier GO_term References
GO:0002020IPI-protease binding25239945
GO:0004842IDA-ubiquitin-protein transferase activity17016439
GO:0004842IMP-ubiquitin-protein transferase activity19720873
GO:0004872TAS-receptor activity9689122
GO:0005515IPI-protein binding12032852
GO:0008270IEA-zinc ion binding-
GO:0016874TAS-ligase activity10500182
GO:0019787IDA-ubiquitin-like protein transferase activity17016439
GO:0061630IBA-ubiquitin protein ligase activity-
GO:1904264TAS-ubiquitin protein ligase activity involved in ERAD pathway-
GO ID Evidence Qualifier GO_term References
GO:0000209IBA-protein polyubiquitination-
GO:0008285IDA-negative regulation of cell proliferation17016439
GO:0016567IDA-protein ubiquitination17016439
GO:0016567IMP-protein ubiquitination19720873
GO:0017148IDA-negative regulation of translation20068067
GO:0030433IEA-ubiquitin-dependent ERAD pathway-
GO:0031396IDA-regulation of protein ubiquitination10500182
GO:0031648IMP-protein destabilization25239945
GO:0036503IMP-ERAD pathway25239945
GO:0043161IBA-proteasome-mediated ubiquitin-dependent protein catabolic process-
GO:0060628IDA-regulation of ER to Golgi vesicle-mediated transport19706601
GO:0070613IDA-regulation of protein processing19706601
GO:1904380TAS-endoplasmic reticulum mannose trimming-
GO:2000060IMP-positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process25239945
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
RNF139UBE2H11640119549727 Two-hybrid
RNF139UBE2H11317619549727 Two-hybrid
UBE2URNF13912715619690564 Two-hybrid
UBE2URNF13911640119690564 Two-hybrid
UBE2ZRNF13911640119690564 Two-hybrid
UBE2ZRNF13912241919690564 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1923091
  • Data Attributes: HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-080401-4'