Annotation Details for EGLN3

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Basic Information Top

Gene Symbol:	EGLN3 ( FLJ21620,HIFPH3,MGC125998,MGC125999,PHD3 )
Gene Full Name:	egl nine homolog 3 (C. elegans)
Band:	14q13.1
Quick Links	Entrez ID:112399; OMIM: 606426; Uniprot ID:EGLN3_HUMAN; ENSEMBL ID: ENSG00000129521; HGNC ID: 14661
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

AlzGene, PDGene and SZGene

Gene Ontology

Cellular Component:5 results
Molecular Function:6 results
Biological Process:10 results

GO ID	Evidence	Qualifier	GO_term	References
GO:0005634	IDA	-	nucleus	12615973
GO:0005654	TAS	-	nucleoplasm	-
GO:0005737	IDA	-	cytoplasm	12615973
GO:0005829	IDA	-	cytosol	-
GO:0005829	TAS	-	cytosol	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0005506	IEA	-	iron ion binding	-
GO:0005515	IPI	-	protein binding	15721254
GO:0016706	IDA	-	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	22955912
GO:0031418	IEA	-	L-ascorbic acid binding	-
GO:0031545	EXP	-	peptidyl-proline 4-dioxygenase activity	12615973
GO:0031545	IDA	-	peptidyl-proline 4-dioxygenase activity	11598268

GO ID	Evidence	Qualifier	GO_term	References
GO:0001666	IEP	-	response to hypoxia	20978507
GO:0006915	IEP	-	apoptotic process	20978507
GO:0006919	IEP	-	activation of cysteine-type endopeptidase activity involved in apoptotic process	20978507
GO:0006974	IEA	-	cellular response to DNA damage stimulus	-
GO:0018126	IDA	-	protein hydroxylation	19584355
GO:0018401	IDA	-	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	11598268
GO:0042127	IEP	-	regulation of cell proliferation	20978507
GO:0043523	ISS	-	regulation of neuron apoptotic process	-
GO:0055114	IEA	-	oxidation-reduction process	-
GO:0061418	TAS	-	regulation of transcription from RNA polymerase II promoter in response to hypoxia	-

Protein-Protein Interaction

BioGRID:4 results
BIND:0 results
HPRD:0 results

Gene Symbol	Interactant	Interaction ID	References	Description
EGLN3	HIF1A	125185	15721254 18264140	Reconstituted Complex
EGLN3	HIF1A	109338	15721254 18264140	Reconstituted Complex
EGLN3	OS9	116156	15721254	Affinity Capture-Western
EGLN3	OS9	125185	15721254	Affinity Capture-Western

AlzGene, PDGene and SZGene

Animal Model

Mouse:1 results
Fruit Fly:0 results

MGI ID: MGI:1932288
Data Attributes: MGI curated and HomoloGene calculated