AutismKB 2.0

Annotation Details for PNKP


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PNKP ( MCSZ,PNK )
Gene Full Name: polynucleotide kinase 3'-phosphatase
Band: 19q13.33
Quick LinksEntrez ID:11284; OMIM: 605610; Uniprot ID:PNKP_HUMAN; ENSEMBL ID: ENSG00000039650; HGNC ID: 9154
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus10446193
GO:0005654TAS-nucleoplasm-
GO:0005730IDA-nucleolus-
GO:0005739IEA-mitochondrion-
GO:0016020IDA-membrane19946888
GO ID Evidence Qualifier GO_term References
GO:0003684NAS-damaged DNA binding10446193
GO:0003690TAS-double-stranded DNA binding10446193
GO:0004519NAS-endonuclease activity10446192
GO:0005515IPI-protein binding16189514
GO:0005524NAS-ATP binding10446192
GO:0017076NAS-purine nucleotide binding10446193
GO:0019201IDA-nucleotide kinase activity10446192
GO:0046403IDA-polynucleotide 3'-phosphatase activity10446192
GO:0046403TAS-polynucleotide 3'-phosphatase activity-
GO:0046404IDA-ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity10446193
GO ID Evidence Qualifier GO_term References
GO:0000718NAS-nucleotide-excision repair, DNA damage removal10446193
GO:0006261NAS-DNA-dependent DNA replication10446192
GO:0006281IGI-DNA repair10446192
GO:0006979IDA-response to oxidative stress10446192
GO:0009314NAS-response to radiation10446193
GO:0009314TAS-response to radiation10446192
GO:0016311IDA-dephosphorylation10446193
GO:0032212IMP-positive regulation of telomere maintenance via telomerase21531765
GO:0042769IDA-DNA damage response, detection of DNA damage10446192
GO:0042769NAS-DNA damage response, detection of DNA damage10446193
GO:0046939IDA-nucleotide phosphorylation10446193
GO:0051973IMP-positive regulation of telomerase activity21531765
GO:0090305IEA-nucleic acid phosphodiester bond hydrolysis-
GO:0098504IBA-DNA 3' dephosphorylation involved in DNA repair-
GO:0098506IEA-polynucleotide 3' dephosphorylation-
GO:1904355IMP-positive regulation of telomere capping21531765
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PNKPLIG311644011163244 17353931 Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
PNKPLIG311016811163244 17353931 Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
PNKPLIG411644017353931 Affinity Capture-MS
PNKPLIG411016917353931 Affinity Capture-MS
PNKPMAGEA1111644016189514 Two-hybrid
PNKPMAGEA1111028416189514 Two-hybrid
PNKPMCM311644017353931 Affinity Capture-MS
PNKPMCM311034017353931 Affinity Capture-MS
PNKPTRIM3711644016189514 Two-hybrid
PNKPTRIM3711067816189514 Two-hybrid
PNKPPOLB11644011163244 Affinity Capture-Western; Two-hybrid
PNKPPOLB11141911163244 Affinity Capture-Western; Two-hybrid
PNKPXRCC111644011163244 17353931 Affinity Capture-MS; Affinity Capture-Western; Far Western; Two-hybrid
PNKPXRCC111334911163244 17353931 Affinity Capture-MS; Affinity Capture-Western; Far Western; Two-hybrid
PNKPXRCC411644017353931 Affinity Capture-MS
PNKPXRCC411335217353931 Affinity Capture-MS
PNKPSLC25A1211644017353931 Affinity Capture-MS
PNKPSLC25A1211416417353931 Affinity Capture-MS
PNKPNOL311447717353931 Affinity Capture-MS
PNKPNOL311644017353931 Affinity Capture-MS
PNKPNUP9311644017353931 Affinity Capture-MS
PNKPNUP9311504117353931 Affinity Capture-MS
PNKPYWHAQ11644017353931 Affinity Capture-MS
PNKPYWHAQ11616817353931 Affinity Capture-MS
PNKPDDX2011638717353931 Affinity Capture-MS
PNKPDDX2011644017353931 Affinity Capture-MS
MYOZ1PNKP11644016189514 Two-hybrid
MYOZ1PNKP12184916189514 Two-hybrid
KRTAP4-12PNKP11644016189514 Two-hybrid
KRTAP4-12PNKP12375616189514 Two-hybrid
HEATR2PNKP11644017353931 Affinity Capture-MS
HEATR2PNKP12026017353931 Affinity Capture-MS
NOM1PNKP12218217353931 Affinity Capture-MS
NOM1PNKP11644017353931 Affinity Capture-MS
LAS1LPNKP11644017353931 Affinity Capture-MS
LAS1LPNKP12362017353931 Affinity Capture-MS
ATAD3BPNKP12377417353931 Affinity Capture-MS
ATAD3BPNKP11644017353931 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1891698
  • Data Attributes: MGI curated and HomoloGene calculated
No data