AutismKB 2.0

Annotation Details for TWF2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:TWF2 ( A6RP,A6r,PTK9L )
Gene Full Name: twinfilin, actin-binding protein, homolog 2 (Drosophila)
Band: 3p21.2
Quick LinksEntrez ID:11344; OMIM: 607433; Uniprot ID:TWF2_HUMAN; ENSEMBL ID: ENSG00000173366,ENSG00000247596; HGNC ID: 9621
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IDA-cytoplasm25468996
GO:0005737NAS-cytoplasm10406962
GO:0005856IEA-cytoskeleton-
GO:0030016ISS-myofibril18837697
GO:0030027ISS-lamellipodium12807912
GO:0030175ISS-filopodium12807912
GO:0030426IDA-growth cone17910947
GO:0032420ISS-stereocilium19955359
GO:0048471ISS-perinuclear region of cytoplasm12807912
GO:0070062IDA-extracellular exosome19199708
GO ID Evidence Qualifier GO_term References
GO:0003723IDA-RNA binding22658674
GO:0003785ISS-actin monomer binding12807912
GO:0005080IPI-protein kinase C binding10406962
GO:0005515IPI-protein binding21044950
GO:0005524IDA-ATP binding10406962
GO:0005546ISS-phosphatidylinositol-4,5-bisphosphate binding12807912
GO:0045296IDA-cadherin binding25468996
GO ID Evidence Qualifier GO_term References
GO:0010592IMP-positive regulation of lamellipodium assembly17910947
GO:0010976IMP-positive regulation of neuron projection development17910947
GO:0030030IEA-cell projection organization-
GO:0030837ISS-negative regulation of actin filament polymerization12807912
GO:0032532IC-regulation of microvillus length19955359
GO:0032956IMP-regulation of actin cytoskeleton organization17910947
GO:0042989ISS-sequestering of actin monomers18837697
GO:0045773IMP-positive regulation of axon extension17910947
GO:0051016ISS-barbed-end actin filament capping18837697
GO:0071300IMP-cellular response to retinoic acid17910947
GO:0071363IMP-cellular response to growth factor stimulus17910947
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TWF2CAPZA111647217353931 Affinity Capture-MS
TWF2CAPZA110727917353931 Affinity Capture-MS
TWF2CAPZA211647217353931 Affinity Capture-MS
TWF2CAPZA210728017353931 Affinity Capture-MS
TWF2CAPZB10728217353931 Affinity Capture-MS
TWF2CAPZB11647217353931 Affinity Capture-MS
TWF2CHGB11647216169070 Two-hybrid
TWF2CHGB10753916169070 Two-hybrid
TWF2KRT3111007917353931 Affinity Capture-MS
TWF2KRT3111647217353931 Affinity Capture-MS
TWF2KRT8211008617353931 Affinity Capture-MS
TWF2KRT8211647217353931 Affinity Capture-MS
TWF2KRT8511008917353931 Affinity Capture-MS
TWF2KRT8511647217353931 Affinity Capture-MS
TWF2KRT3611423617353931 Affinity Capture-MS
TWF2KRT3611647217353931 Affinity Capture-MS
ERC1TWF211671417353931 Affinity Capture-MS
ERC1TWF211647217353931 Affinity Capture-MS
VRK3TWF211647217353931 Affinity Capture-MS
VRK3TWF211939417353931 Affinity Capture-MS
LYARTWF211647217353931 Affinity Capture-MS
LYARTWF212078017353931 Affinity Capture-MS
ACTR3BTWF211647217353931 Affinity Capture-MS
ACTR3BTWF212142917353931 Affinity Capture-MS
ELOVL1TWF211647217353931 Affinity Capture-MS
ELOVL1TWF212231217353931 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1346078
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved