AutismKB 2.0

Annotation Details for CHRNA3


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Basic Information Top
Gene Symbol:CHRNA3 ( LNCR2,MGC104879,NACHRA3,PAOD2 )
Gene Full Name: cholinergic receptor, nicotinic, alpha 3
Band: 15q25.1
Quick LinksEntrez ID:1136; OMIM: 118503; Uniprot ID:ACHA3_HUMAN; ENSEMBL ID: ENSG00000080644; HGNC ID: 1957
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005886TAS-plasma membrane-
GO:0005892IDA-acetylcholine-gated channel complex8906617
GO:0014069ISS-postsynaptic density-
GO:0016021NAS-integral component of membrane8906617
GO:0030054IEA-cell junction-
GO:0030425ISS-dendrite-
GO:0043025ISS-neuronal cell body-
GO:0044853ISS-plasma membrane raft-
GO:0045211IEA-postsynaptic membrane-
GO ID Evidence Qualifier GO_term References
GO:0004993IBA-G-protein coupled serotonin receptor activity-
GO:0005515IPI-protein binding27344019
GO:0015276TAS-ligand-gated ion channel activity20438829
GO:0015464IDA-acetylcholine receptor activity8906617
GO:0022848IDA-acetylcholine-gated cation-selective channel activity8906617
GO:0022848ISS-acetylcholine-gated cation-selective channel activity-
GO:0022848TAS-acetylcholine-gated cation-selective channel activity20438829
GO:0042166IC-acetylcholine binding8906617
GO ID Evidence Qualifier GO_term References
GO:0006811NAS-ion transport8906617
GO:0006940ISS-regulation of smooth muscle contraction-
GO:0007165IDA-signal transduction8906617
GO:0007171ISS-activation of transmembrane receptor protein tyrosine kinase activity-
GO:0007210IBA-serotonin receptor signaling pathway-
GO:0007271ISS-synaptic transmission, cholinergic-
GO:0007399IMP-nervous system development11450844
GO:0007626ISS-locomotory behavior-
GO:0014056ISS-regulation of acetylcholine secretion, neurotransmission-
GO:0034220IEA-ion transmembrane transport-
GO:0035095IMP-behavioral response to nicotine18227835
GO:0042391ISS-regulation of membrane potential-
GO:0048814ISS-regulation of dendrite morphogenesis-
GO:0060079ISS-excitatory postsynaptic potential-
GO:0060084IMP-synaptic transmission involved in micturition11450844
GO:0095500ISS-acetylcholine receptor signaling pathway-
GO:0098664IEA-G-protein coupled serotonin receptor signaling pathway-
GO:1905144ISS-response to acetylcholine-
Protein-Protein Interaction Top
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
CHRNA3409 -36 polyT, 563+8 G>C, A477G, p(CTG) exon 1, rs3743074, rs804868 Gene overview in AlzGene
No data
Gene Symbol Poly Names Gene overview in SZGene
CHRNA3rs1051730, rs1317286 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:87887
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-070822-1'