Gene Symbol:	CHRNA4 ( BFNC,EBN,EBN1,FLJ95812,NACHR,NACHRA4,NACRA4 )
Gene Full Name:	cholinergic receptor, nicotinic, alpha 4
Band:	20q13.33
Quick Links	Entrez ID:1137; OMIM: 118504; Uniprot ID:ACHA4_HUMAN; ENSEMBL ID: ENSG00000101204; HGNC ID: 1958
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0005886	ISS	-	plasma membrane	-
GO:0005886	TAS	-	plasma membrane	-
GO:0005892	IDA	-	acetylcholine-gated channel complex	8906617
GO:0009897	ISS	-	external side of plasma membrane	-
GO:0016020	ISS	-	membrane	-
GO:0016021	NAS	-	integral component of membrane	8906617
GO:0030054	IEA	-	cell junction	-
GO:0030425	ISS	-	dendrite	-
GO:0043025	ISS	-	neuronal cell body	-
GO:0045211	IEA	-	postsynaptic membrane	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0005515	IPI	-	protein binding	27344019
GO:0015276	TAS	-	ligand-gated ion channel activity	20438829
GO:0015464	IDA	-	acetylcholine receptor activity	8906617
GO:0022848	IBA	contributes_to	acetylcholine-gated cation-selective channel activity	-
GO:0022848	IDA	-	acetylcholine-gated cation-selective channel activity	8906617
GO:0022848	TAS	-	acetylcholine-gated cation-selective channel activity	20438829
GO:0042166	IBA	contributes_to	acetylcholine binding	-
GO:0042166	IC	-	acetylcholine binding	8906617

GO ID	Evidence	Qualifier	GO_term	References
GO:0001508	ISS	-	action potential	-
GO:0001666	IDA	-	response to hypoxia	12189247
GO:0006281	IMP	-	DNA repair	16332175
GO:0006811	NAS	-	ion transport	8906617
GO:0006816	ISS	-	calcium ion transport	-
GO:0006979	IMP	-	response to oxidative stress	16332175
GO:0007165	IDA	-	signal transduction	8906617
GO:0007268	NAS	-	chemical synaptic transmission	7550350
GO:0007271	IBA	-	synaptic transmission, cholinergic	-
GO:0007271	ISS	-	synaptic transmission, cholinergic	-
GO:0007274	IBA	-	neuromuscular synaptic transmission	-
GO:0007585	IEA	-	respiratory gaseous exchange	-
GO:0007626	IEA	-	locomotory behavior	-
GO:0014059	ISS	-	regulation of dopamine secretion	-
GO:0019233	ISS	-	sensory perception of pain	-
GO:0035094	IDA	-	response to nicotine	12189247
GO:0035095	IMP	-	behavioral response to nicotine	17955458
GO:0035640	IEA	-	exploration behavior	-
GO:0042113	ISS	-	B cell activation	-
GO:0042391	ISS	-	regulation of membrane potential	-
GO:0050877	IMP	-	neurological system process	7550350
GO:0050890	IMP	-	cognition	14623738
GO:0051899	ISS	-	membrane depolarization	-
GO:0060079	IEA	-	excitatory postsynaptic potential	-
GO:0060080	ISS	-	inhibitory postsynaptic potential	-
GO:0095500	IEA	-	acetylcholine receptor signaling pathway	-
GO:0098655	IBA	-	cation transmembrane transport	-

Gene Symbol	Interactant	Interaction ID	References	Description
YWHAH	CHRNA4	107559	11352901	Two-hybrid
YWHAH	CHRNA4	113365	11352901	Two-hybrid

AutismKB 2.0

Annotation Details for CHRNA4