AutismKB 2.0

Annotation Details for CHRNA4


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Basic Information Top
Gene Symbol:CHRNA4 ( BFNC,EBN,EBN1,FLJ95812,NACHR,NACHRA4,NACRA4 )
Gene Full Name: cholinergic receptor, nicotinic, alpha 4
Band: 20q13.33
Quick LinksEntrez ID:1137; OMIM: 118504; Uniprot ID:ACHA4_HUMAN; ENSEMBL ID: ENSG00000101204; HGNC ID: 1958
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005886ISS-plasma membrane-
GO:0005886TAS-plasma membrane-
GO:0005892IDA-acetylcholine-gated channel complex8906617
GO:0009897ISS-external side of plasma membrane-
GO:0016020ISS-membrane-
GO:0016021NAS-integral component of membrane8906617
GO:0030054IEA-cell junction-
GO:0030425ISS-dendrite-
GO:0043025ISS-neuronal cell body-
GO:0045211IEA-postsynaptic membrane-
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding27344019
GO:0015276TAS-ligand-gated ion channel activity20438829
GO:0015464IDA-acetylcholine receptor activity8906617
GO:0022848IBAcontributes_toacetylcholine-gated cation-selective channel activity-
GO:0022848IDA-acetylcholine-gated cation-selective channel activity8906617
GO:0022848TAS-acetylcholine-gated cation-selective channel activity20438829
GO:0042166IBAcontributes_toacetylcholine binding-
GO:0042166IC-acetylcholine binding8906617
GO ID Evidence Qualifier GO_term References
GO:0001508ISS-action potential-
GO:0001666IDA-response to hypoxia12189247
GO:0006281IMP-DNA repair16332175
GO:0006811NAS-ion transport8906617
GO:0006816ISS-calcium ion transport-
GO:0006979IMP-response to oxidative stress16332175
GO:0007165IDA-signal transduction8906617
GO:0007268NAS-chemical synaptic transmission7550350
GO:0007271IBA-synaptic transmission, cholinergic-
GO:0007271ISS-synaptic transmission, cholinergic-
GO:0007274IBA-neuromuscular synaptic transmission-
GO:0007585IEA-respiratory gaseous exchange-
GO:0007626IEA-locomotory behavior-
GO:0014059ISS-regulation of dopamine secretion-
GO:0019233ISS-sensory perception of pain-
GO:0035094IDA-response to nicotine12189247
GO:0035095IMP-behavioral response to nicotine17955458
GO:0035640IEA-exploration behavior-
GO:0042113ISS-B cell activation-
GO:0042391ISS-regulation of membrane potential-
GO:0050877IMP-neurological system process7550350
GO:0050890IMP-cognition14623738
GO:0051899ISS-membrane depolarization-
GO:0060079IEA-excitatory postsynaptic potential-
GO:0060080ISS-inhibitory postsynaptic potential-
GO:0095500IEA-acetylcholine receptor signaling pathway-
GO:0098655IBA-cation transmembrane transport-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
YWHAHCHRNA410755911352901 Two-hybrid
YWHAHCHRNA411336511352901 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
CHRNA4145 -55 G>A, 1770+11_intron5, 1770+192_intron5, C1250T, C1783T, G744A, T1545C, c.651_exon5, c.690_exon5, rs1044393, rs1044394, rs1044396, rs1044397, rs2273502, rs2273506, rs3827020 Gene overview in AlzGene
Gene Symbol Poly Names Gene overview in PDGene
CHRNA4rs1044396, rs2273504, rs3787137 Gene overview in PDGene
Gene Symbol Poly Names Gene overview in SZGene
CHRNA4rs1044396, rs1044397, rs2236196, rs2273504, rs2273506, rs3746372, rs3787116, rs4522666, rs755203 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:87888
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-090505-3'