AutismKB 2.0

Annotation Details for CHRNA7


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Basic Information Top
Gene Symbol:CHRNA7 ( CHRNA7-2,NACHRA7 )
Gene Full Name: cholinergic receptor, nicotinic, alpha 7
Band: 15q13.3
Quick LinksEntrez ID:1139; OMIM: 118511; Uniprot ID:ACHA7_HUMAN; ENSEMBL ID: ENSG00000175344; HGNC ID: 1960
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005886IDA-plasma membrane12508119
GO:0005886TAS-plasma membrane-
GO:0005892IDA-acetylcholine-gated channel complex8906617
GO:0016021NAS-integral component of membrane8145738
GO:0030054IEA-cell junction-
GO:0044853ISS-plasma membrane raft-
GO:0045211IEA-postsynaptic membrane-
GO:0098794TAS-postsynapse26224839
GO ID Evidence Qualifier GO_term References
GO:0001540IPI-amyloid-beta binding10681545
GO:0005216IDA-ion channel activity17898229
GO:0005262TAS-calcium channel activity11404397
GO:0005515IPI-protein binding27344019
GO:0015276TAS-ligand-gated ion channel activity-
GO:0015464IDA-acetylcholine receptor activity8906617
GO:0015643IDA-toxic substance binding12508119
GO:0017081IDA-chloride channel regulator activity8145738
GO:0022848IDA-acetylcholine-gated cation-selective channel activity8145738
GO:0022848ISS-acetylcholine-gated cation-selective channel activity-
GO:0042166IDA-acetylcholine binding8145738
GO:0042803IDA-protein homodimerization activity8145738
GO ID Evidence Qualifier GO_term References
GO:0000187IDA-activation of MAPK activity10771023
GO:0001666IDA-response to hypoxia12189247
GO:0001934ISS-positive regulation of protein phosphorylation-
GO:0006811NAS-ion transport8906617
GO:0006816IDA-calcium ion transport8145738
GO:0006816IMP-calcium ion transport10771023
GO:0006874IMP-cellular calcium ion homeostasis16280133
GO:0007165IDA-signal transduction8906617
GO:0007611ISS-learning or memory-
GO:0007613ISS-memory-
GO:0007613NAS-memory10681545
GO:0007614ISS-short-term memory-
GO:0008284IMP-positive regulation of cell proliferation16280133
GO:0032720IDA-negative regulation of tumor necrosis factor production12508119
GO:0032720IMP-negative regulation of tumor necrosis factor production12508119
GO:0034220IDA-ion transmembrane transport21718690
GO:0035094IDA-response to nicotine8145738
GO:0035094ISS-response to nicotine-
GO:0045766IMP-positive regulation of angiogenesis12189247
GO:0048813ISS-dendrite morphogenesis-
GO:0050808ISS-synapse organization-
GO:0050890IMP-cognition16754836
GO:0050890NAS-cognition10681545
GO:0050893ISS-sensory processing-
GO:0051247ISS-positive regulation of protein metabolic process-
GO:0060079IEA-excitatory postsynaptic potential-
GO:0070374ISS-positive regulation of ERK1 and ERK2 cascade-
GO:0070588IEA-calcium ion transmembrane transport-
GO:0095500ISS-acetylcholine receptor signaling pathway-
GO:0097061ISS-dendritic spine organization-
GO:0098815ISS-modulation of excitatory postsynaptic potential-
GO:1900273ISS-positive regulation of long-term synaptic potentiation-
GO:1901214ISS-regulation of neuron death-
GO:1902004ISS-positive regulation of amyloid-beta formation-
GO:1902430IGI-negative regulation of amyloid-beta formation20708605
GO:1902991IGI-regulation of amyloid precursor protein catabolic process20708605
GO:1904645ISS-response to amyloid-beta-
GO:1905144IDA-response to acetylcholine17898229
GO:1905144ISS-response to acetylcholine-
GO:1905906ISS-regulation of amyloid fibril formation-
GO:1905920ISS-positive regulation of CoA-transferase activity-
GO:2000463ISS-positive regulation of excitatory postsynaptic potential-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CHRNA7ADCY610756112748066 Affinity Capture-Western
CHRNA7ADCY610662512748066 Affinity Capture-Western
FYNCHRNA710756111278378 Affinity Capture-Western
FYNCHRNA710881011278378 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
CHRNA7CHRNA7_dup, polyT (intron 3), rs12916879, rs1514246, rs1514263, rs16956223, rs1827294, rs2337506, rs35057608, rs4779563, rs6494223, rs7175581, rs7179733, rs8027814, rs883473, rs904951, rs904952 Gene overview in AlzGene
Gene Symbol Poly Names Gene overview in PDGene
CHRNA7rs2253967 Gene overview in PDGene
Gene Symbol Poly Names Gene overview in SZGene
CHRNA7CHRNA7PROM, CHRNA7_-1252C/A, CHRNA7_-178Indel, CHRNA7_-190Indel, CHRNA7_-46G/T, CHRNA7_-86C/T, CHRNA7_-92A/G, CHRNA7_933A/G, CHRNA7_STR, D15S128, D15S1360, D15S144, D15S659, L76630, rs10438342, rs12915265, rs12916879, rs1514246, rs1514252, rs1604265, rs2221223, rs2337506, rs2337980, rs2611605, rs28531779, rs3087454, rs3826029, rs3935407, rs4779563, rs4779969, rs6494165, rs6494223, rs7174479, rs7179733, rs7402321, rs8035668, rs868437, rs883473, rs904951, rs904952, rs982574 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:99779
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040108-3'