AutismKB 2.0

Annotation Details for NLRP3


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Basic Information Top
Gene Symbol:NLRP3 ( AGTAVPRL,AII,AII/AVP,AVP,C1orf7,CIAS1,CLR1.1,FCAS,FCU,FLJ95925,MWS,NALP3,PYPAF1 )
Gene Full Name: NLR family, pyrin domain containing 3
Band: 1q44
Quick LinksEntrez ID:114548; OMIM: 606416; Uniprot ID:NALP3_HUMAN; ENSEMBL ID: ENSG00000162711; HGNC ID: 16400
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576IEA-extracellular region-
GO:0005634ISS-nucleus-
GO:0005737IDA-cytoplasm17164409
GO:0005737TAS-cytoplasm15967716
GO:0005783IEA-endoplasmic reticulum-
GO:0005829TAS-cytosol-
GO:0072559IDA-NLRP3 inflammasome complex15030775
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding11786556
GO:0005524IEA-ATP binding-
GO:0008134ISS-transcription factor binding-
GO:0042802IPI-identical protein binding23582325
GO:0042834TAS-peptidoglycan binding15967716
GO:0043565ISS-sequence-specific DNA binding-
GO ID Evidence Qualifier GO_term References
GO:0002674IMP-negative regulation of acute inflammatory response11687797
GO:0002830ISS-positive regulation of type 2 immune response-
GO:0006351IEA-transcription, DNA-templated-
GO:0006915NAS-apoptotic process12032915
GO:0006919IEA-activation of cysteine-type endopeptidase activity involved in apoptotic process-
GO:0006952TAS-defense response15967716
GO:0006954IMP-inflammatory response12093792
GO:0007165NAS-signal transduction11786556
GO:0009595TAS-detection of biotic stimulus15967716
GO:0016579TAS-protein deubiquitination-
GO:0032088IDA-negative regulation of NF-kappaB transcription factor activity14662828
GO:0032611IEA-interleukin-1 beta production-
GO:0032621IEA-interleukin-18 production-
GO:0032736IEA-positive regulation of interleukin-13 production-
GO:0032753ISS-positive regulation of interleukin-4 production-
GO:0032754IEA-positive regulation of interleukin-5 production-
GO:0042347IDA-negative regulation of NF-kappaB import into nucleus14662828
GO:0043280IDA-positive regulation of cysteine-type endopeptidase activity involved in apoptotic process15030775
GO:0044546IEA-NLRP3 inflammasome complex assembly-
GO:0045087IEA-innate immune response-
GO:0045630ISS-positive regulation of T-helper 2 cell differentiation-
GO:0045944ISS-positive regulation of transcription from RNA polymerase II promoter-
GO:0050701IEA-interleukin-1 secretion-
GO:0050713IMP-negative regulation of interleukin-1 beta secretion12483741
GO:0050718IDA-positive regulation of interleukin-1 beta secretion15030775
GO:0050728IMP-negative regulation of inflammatory response12483741
GO:0051092IDA-positive regulation of NF-kappaB transcription factor activity19158675
GO:0051259TAS-protein oligomerization15967716
GO:0051607IEA-defense response to virus-
GO:0071222IMP-cellular response to lipopolysaccharide12483741
GO:2000321IEA-positive regulation of T-helper 17 cell differentiation-
GO:2000553ISS-positive regulation of T-helper 2 cell cytokine production-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NLRP3NLRC412531915107016 Affinity Capture-Western
NLRP3NLRC412181415107016 Affinity Capture-Western
Gene Symbol Interactant Interaction ID References Description
NLRP3PYCARD18360511786556 PYPAF1 interacts with ASC.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2653833
  • Data Attributes: MGI curated and HomoloGene calculated
No data