AutismKB 2.0

Annotation Details for CLU


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Basic Information Top
Gene Symbol:CLU ( APOJ,CLI,KUB1,MGC24903,SGP-2,SGP2,SP-40,TRPM-2,TRPM2 )
Gene Full Name: clusterin
Band: 8p21.1
Quick LinksEntrez ID:1191; OMIM: 185430; Uniprot ID:CLUS_HUMAN; ENSEMBL ID: ENSG00000120885; HGNC ID: 2095
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region23164821
GO:0005615IDA-extracellular space11123922
GO:0005622TAS-intracellular23164821
GO:0005634IEA-nucleus-
GO:0005737IDA-cytoplasm9560017
GO:0005739IDA-mitochondrion16113678
GO:0005783IEA-endoplasmic reticulum-
GO:0005794ISS-Golgi apparatus-
GO:0005829IEA-cytosol-
GO:0009986IDA-cell surface17567961
GO:0031012IDA-extracellular matrix23658023
GO:0031012IDAcolocalizes_withextracellular matrix20551380
GO:0031093TAS-platelet alpha granule lumen-
GO:0031966IEA-mitochondrial membrane-
GO:0034366IDA-spherical high-density lipoprotein particle16682745
GO:0042583IEA-chromaffin granule-
GO:0043234IDA-protein complex9228033
GO:0048471IDA-perinuclear region of cytoplasm20068069
GO:0070062IDA-extracellular exosome19056867
GO:0071944IDAcolocalizes_withcell periphery21803450
GO:0072562IDA-blood microparticle22516433
GO:0097418IDA-neurofibrillary tangle9560017
GO:0097440IDA-apical dendrite9560017
GO ID Evidence Qualifier GO_term References
GO:0001540IPI-amyloid-beta binding9228033
GO:0005515IPI-protein binding16113678
GO:0016887IDANOTATPase activity11123922
GO:0031625IDA-ubiquitin protein ligase binding20068069
GO:0050750IPI-low-density lipoprotein particle receptor binding9228033
GO:0051087ISS-chaperone binding-
GO:0051787IDA-misfolded protein binding11123922
GO:0051787IPI-misfolded protein binding19996109
GO ID Evidence Qualifier GO_term References
GO:0000902IDA-cell morphogenesis15857407
GO:0001774IDA-microglial cell activation15857407
GO:0001836IC-release of cytochrome c from mitochondria16113678
GO:0002576TAS-platelet degranulation-
GO:0006629NAS-lipid metabolic process2387851
GO:0006956TAS-complement activation1585460
GO:0006958IEA-complement activation, classical pathway-
GO:0009615IEP-response to virus16548883
GO:0010628ISS-positive regulation of gene expression-
GO:0017038IDA-protein import24446231
GO:0019730TAS-antimicrobial humoral response-
GO:0030449TAS-regulation of complement activation-
GO:0032286IMP-central nervous system myelin maintenance21543606
GO:0032436IMP-positive regulation of proteasomal ubiquitin-dependent protein catabolic process20068069
GO:0032463IDA-negative regulation of protein homooligomerization22179788
GO:0032463IMP-negative regulation of protein homooligomerization16113678
GO:0032464IDA-positive regulation of protein homooligomerization22179788
GO:0032760IDA-positive regulation of tumor necrosis factor production15857407
GO:0043691TAS-reverse cholesterol transport16682745
GO:0045087IEA-innate immune response-
GO:0045429IDA-positive regulation of nitric oxide biosynthetic process15857407
GO:0048260IGI-positive regulation of receptor-mediated endocytosis9228033
GO:0050821IDA-protein stabilization11123922
GO:0051092IMP-positive regulation of NF-kappaB transcription factor activity20068069
GO:0051131IDA-chaperone-mediated protein complex assembly17412999
GO:0051788IDA-response to misfolded protein19996109
GO:0060548IMP-negative regulation of cell death21803450
GO:0060548TAS-negative regulation of cell death23164821
GO:0061077IDA-chaperone-mediated protein folding11123922
GO:0061518IDA-microglial cell proliferation15857407
GO:0061740IC-protein targeting to lysosome involved in chaperone-mediated autophagy9228033
GO:0061741IC-chaperone-mediated protein transport involved in chaperone-mediated autophagy9228033
GO:0090201TAS-negative regulation of release of cytochrome c from mitochondria21803450
GO:1900221IDA-regulation of amyloid-beta clearance24446231
GO:1901214IDA-regulation of neuron death17412999
GO:1901214IMP-regulation of neuron death9560017
GO:1901216IDA-positive regulation of neuron death15857407
GO:1901216IMP-positive regulation of neuron death15897157
GO:1901216ISS-positive regulation of neuron death-
GO:1902004ISS-positive regulation of amyloid-beta formation-
GO:1902230IMP-negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage16113678
GO:1902430IDA-negative regulation of amyloid-beta formation12047389
GO:1902847IMP-regulation of neuronal signal transduction21397462
GO:1902949IMP-positive regulation of tau-protein kinase activity15897157
GO:1902998IMP-positive regulation of neurofibrillary tangle assembly15897157
GO:1903573IMP-negative regulation of response to endoplasmic reticulum stress21803450
GO:1905892IMP-negative regulation of cellular response to thapsigargin21803450
GO:1905895IMP-negative regulation of cellular response to tunicamycin21803450
GO:1905907IDA-negative regulation of amyloid fibril formation22179788
GO:1905907TAS-negative regulation of amyloid fibril formation9228033
GO:2000060IMP-positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process20068069
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CLUC71076038345200 Reconstituted Complex
CLUC71071918345200 Reconstituted Complex
CLUC8B1076038345200 Reconstituted Complex
CLUC8B1071938345200 Reconstituted Complex
CLUC91076038345200 Reconstituted Complex
CLUC91071968345200 Reconstituted Complex
LRP2CLU1076037768901 Reconstituted Complex
LRP2CLU1102167768901 Reconstituted Complex
TGFBR1CLU1076038555189 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TGFBR1CLU1129048555189 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TGFBR2CLU1076038555189 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TGFBR2CLU1129068555189 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
XRCC6CLU10760310219089 12551933 Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybrid
XRCC6CLU10882210219089 12551933 Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybrid
CLUCLU10760312551933 Two-hybrid
LEPCLU10760312824284 Affinity Capture-Western; Reconstituted Complex
LEPCLU11014312824284 Affinity Capture-Western; Reconstituted Complex
VLDLRCLU10760312824284 Far Western
VLDLRCLU11327712824284 Far Western
MMP25CLU10760312860995 Affinity Capture-Western
MMP25CLU12214912860995 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
CLUCLU_229G>C, CLU_48C>A, II, VII, rs11136000, rs2279590, rs3087554, rs3216167, rs7012010, rs7982, rs9331888, rs9331939 Gene overview in AlzGene
No data
Gene Symbol Poly Names Gene overview in SZGene
CLUrs11136000 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:88423
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-1774'