AutismKB 2.0

Annotation Details for SPPL3


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SPPL3 ( DKFZp586C1324,IMP2,MDHV1887,MGC126674,MGC126676,MGC90402,PRO4332,PSL4 )
Gene Full Name: -
Band: 12q24.31
Quick LinksEntrez ID:121665; OMIM: 608240; Uniprot ID:PSL4_HUMAN; ENSEMBL ID: ENSG00000157837; HGNC ID: 30424
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005765IBA-lysosomal membrane-
GO:0005791IDA-rough endoplasmic reticulum15998642
GO:0005886IDA-plasma membrane-
GO:0016020IDA-membrane2313285
GO:0030660IDA-Golgi-associated vesicle membrane16829952
GO:0033116ISS-endoplasmic reticulum-Golgi intermediate compartment membrane-
GO:0043231IDA-intracellular membrane-bounded organelle-
GO:0071458IDA-integral component of cytoplasmic side of endoplasmic reticulum membrane15385547
GO:0071556IDA-integral component of lumenal side of endoplasmic reticulum membrane15385547
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding2313285
GO:0042500IDA-aspartic endopeptidase activity, intramembrane cleaving2313285
GO:0042500IMP-aspartic endopeptidase activity, intramembrane cleaving16873890
GO:0042803IDA-protein homodimerization activity15385547
GO ID Evidence Qualifier GO_term References
GO:0006509IMPNOTmembrane protein ectodomain proteolysis16829952
GO:0007204ISS-positive regulation of cytosolic calcium ion concentration-
GO:0032092ISS-positive regulation of protein binding-
GO:0033619IDA-membrane protein proteolysis2313285
GO:0035307IMP-positive regulation of protein dephosphorylation25384971
GO:0050852IMP-T cell receptor signaling pathway25384971
GO:0050852ISS-T cell receptor signaling pathway-
GO:0051533IMP-positive regulation of NFAT protein import into nucleus25384971
GO:0051533ISS-positive regulation of NFAT protein import into nucleus-
GO:0070886IMP-positive regulation of calcineurin-NFAT signaling cascade25384971
Protein-Protein Interaction Top
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1891433
  • Data Attributes: MGI curated and HomoloGene calculated
No data