AutismKB 2.0

Annotation Details for LEO1


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Basic Information Top
Gene Symbol:LEO1 ( RDL )
Gene Full Name: Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
Band: 15q21.2
Quick LinksEntrez ID:123169; OMIM: 610507; Uniprot ID:LEO1_HUMAN; ENSEMBL ID: ENSG00000166477; HGNC ID: 30401
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0001650IDA-fibrillar center-
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005813IDA-centrosome-
GO:0016593IDA-Cdc73/Paf1 complex16307923
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding15923622
GO:1990269IBA-RNA polymerase II C-terminal domain phosphoserine binding-
GO ID Evidence Qualifier GO_term References
GO:0001711ISS-endodermal cell fate commitment-
GO:0006366TAS-transcription from RNA polymerase II promoter-
GO:0006368TAS-transcription elongation from RNA polymerase II promoter-
GO:0006378IMP-mRNA polyadenylation21329879
GO:0010390IDA-histone monoubiquitination16307923
GO:0016055IEA-Wnt signaling pathway-
GO:0016567TAS-protein ubiquitination-
GO:0019827IDA-stem cell population maintenance19345177
GO:0031442IMP-positive regulation of mRNA 3'-end processing21329879
GO:0032968IDA-positive regulation of transcription elongation from RNA polymerase II promoter20178742
GO:0033523IDA-histone H2B ubiquitination16307923
GO:0045638IDA-negative regulation of myeloid cell differentiation20541477
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter20178742
GO:1904837TAS-beta-catenin-TCF complex assembly-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
LEO1CTR912581715632063 18469135 Affinity Capture-MS; Affinity Capture-Western
LEO1CTR911500415632063 18469135 Affinity Capture-MS; Affinity Capture-Western
LEO1RTF112581718469135 Affinity Capture-MS
LEO1RTF111678018469135 Affinity Capture-MS
LEO1PAF112581715632063 18469135 Affinity Capture-MS; Affinity Capture-Western
LEO1PAF112008115632063 18469135 Affinity Capture-MS; Affinity Capture-Western
LEO1CDC7312581715632063 18469135 Affinity Capture-MS; Affinity Capture-Western
LEO1CDC7312272415632063 18469135 Affinity Capture-MS; Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2685031
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-2435'