AutismKB 2.0

Annotation Details for CCR7


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CCR7 ( BLR2,CD197,CDw197,CMKBR7,EBI1 )
Gene Full Name: chemokine (C-C motif) receptor 7
Band: 17q21.2
Quick LinksEntrez ID:1236; OMIM: 600242; Uniprot ID:CCR7_HUMAN; ENSEMBL ID: ENSG00000126353; HGNC ID: 1608
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005622IDA-intracellular21051556
GO:0005886IDA-plasma membrane21051556
GO:0005886TAS-plasma membrane-
GO:0009897IEA-external side of plasma membrane-
GO:0009986IDA-cell surface18308860
GO:0016021IEA-integral component of membrane-
GO ID Evidence Qualifier GO_term References
GO:0004930TAS-G-protein coupled receptor activity16621978
GO:0016493ISS-C-C chemokine receptor activity-
GO:0035757IPI-chemokine (C-C motif) ligand 19 binding9507024
GO:0035758IPI-chemokine (C-C motif) ligand 21 binding9507024
GO:0038117IDA-C-C motif chemokine 19 receptor activity9507024
GO:0038121IDA-C-C motif chemokine 21 receptor activity9507024
GO ID Evidence Qualifier GO_term References
GO:0001768IC-establishment of T cell polarity12729902
GO:0001954IC-positive regulation of cell-matrix adhesion15569314
GO:0002407IC-dendritic cell chemotaxis15778365
GO:0002408IC-myeloid dendritic cell chemotaxis14592837
GO:0002408IDA-myeloid dendritic cell chemotaxis11602640
GO:0002606ISS-positive regulation of dendritic cell antigen processing and presentation-
GO:0002885ISS-positive regulation of hypersensitivity-
GO:0002922ISS-positive regulation of humoral immune response-
GO:0006954NAS-inflammatory response14592837
GO:0006955IEA-immune response-
GO:0007186TAS-G-protein coupled receptor signaling pathway16621978
GO:0007204TAS-positive regulation of cytosolic calcium ion concentration9153236
GO:0030838IC-positive regulation of actin filament polymerization11242036
GO:0031274IC-positive regulation of pseudopodium assembly11242036
GO:0031529IC-ruffle organization15569314
GO:0032496IEA-response to lipopolysaccharide-
GO:0032649ISS-regulation of interferon-gamma production-
GO:0032735ISS-positive regulation of interleukin-12 production-
GO:0034695IC-response to prostaglandin E14592837
GO:0038115IEA-chemokine (C-C motif) ligand 19 signaling pathway-
GO:0038116IEA-chemokine (C-C motif) ligand 21 signaling pathway-
GO:0043123IC-positive regulation of I-kappaB kinase/NF-kappaB signaling15059845
GO:0043552IC-positive regulation of phosphatidylinositol 3-kinase activity15059845
GO:0045060IEA-negative thymic T cell selection-
GO:0045785IC-positive regulation of cell adhesion15569314
GO:0045860IC-positive regulation of protein kinase activity14592837
GO:0046330IC-positive regulation of JNK cascade15778365
GO:0048872IEA-homeostasis of number of cells-
GO:0050706ISS-regulation of interleukin-1 beta secretion-
GO:0050862IEA-positive regulation of T cell receptor signaling pathway-
GO:0051209IC-release of sequestered calcium ion into cytosol14592837
GO:0051491IC-positive regulation of filopodium assembly15569314
GO:0051897IC-positive regulation of protein kinase B signaling15059845
GO:0070374IC-positive regulation of ERK1 and ERK2 cascade12729902
GO:0071345IDA-cellular response to cytokine stimulus11602640
GO:0071731IC-response to nitric oxide16249377
GO:0072610ISS-interleukin-12 secretion-
GO:0090023IDA-positive regulation of neutrophil chemotaxis21051556
GO:0090630IC-activation of GTPase activity15778365
GO:0097022TAS-lymphocyte migration into lymph node18379575
GO:0097029ISS-mature conventional dendritic cell differentiation-
GO:2000107IC-negative regulation of leukocyte apoptotic process15059845
GO:2000147IC-positive regulation of cell motility15778365
GO:2000510ISS-positive regulation of dendritic cell chemotaxis-
GO:2000522ISS-positive regulation of immunological synapse formation-
GO:2000525ISS-positive regulation of T cell costimulation-
GO:2000526ISS-positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation-
GO:2000547ISS-regulation of dendritic cell dendrite assembly-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CCL19CCR71122669153236 Reconstituted Complex
CCL19CCR71076419153236 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:103011
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-060522-2'