Annotation Details for COMT

View Evidences	View Variants	View Annotations

Basic Information Top

Gene Symbol:	COMT ( - )
Gene Full Name:	catechol-O-methyltransferase
Band:	22q11.21
Quick Links	Entrez ID:1312; OMIM: 116790; Uniprot ID:COMT_HUMAN; ENSEMBL ID: ENSG00000093010; HGNC ID: 2228
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

AlzGene, PDGene and SZGene

Gene Ontology

Cellular Component:10 results
Molecular Function:6 results
Biological Process:19 results

GO ID	Evidence	Qualifier	GO_term	References
GO:0005739	IEA	-	mitochondrion	-
GO:0005829	TAS	-	cytosol	-
GO:0005886	TAS	-	plasma membrane	-
GO:0016020	IDA	-	membrane	19946888
GO:0016021	IEA	-	integral component of membrane	-
GO:0030424	IEA	-	axon	-
GO:0043197	IEA	-	dendritic spine	-
GO:0044297	IEA	-	cell body	-
GO:0045211	IEA	-	postsynaptic membrane	-
GO:0070062	IDA	-	extracellular exosome	19056867

GO ID	Evidence	Qualifier	GO_term	References
GO:0000287	IEA	-	magnesium ion binding	-
GO:0005515	IPI	-	protein binding	16189514
GO:0008168	TAS	-	methyltransferase activity	-
GO:0008171	TAS	-	O-methyltransferase activity	1707278
GO:0016206	TAS	-	catechol O-methyltransferase activity	-
GO:0102084	IEA	-	L-dopa O-methyltransferase activity	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0007565	IEA	-	female pregnancy	-
GO:0007612	IEA	-	learning	-
GO:0007614	IEA	-	short-term memory	-
GO:0008210	IEA	-	estrogen metabolic process	-
GO:0014070	IEA	-	response to organic cyclic compound	-
GO:0016036	IEA	-	cellular response to phosphate starvation	-
GO:0032259	TAS	-	methylation	-
GO:0032496	IEA	-	response to lipopolysaccharide	-
GO:0032502	IEA	-	developmental process	-
GO:0035814	IEA	-	negative regulation of renal sodium excretion	-
GO:0042135	IEA	-	neurotransmitter catabolic process	-
GO:0042420	IEA	-	dopamine catabolic process	-
GO:0042493	IEA	-	response to drug	-
GO:0045963	IEA	-	negative regulation of dopamine metabolic process	-
GO:0048265	IEA	-	response to pain	-
GO:0048609	IEA	-	multicellular organismal reproductive process	-
GO:0048662	IEA	-	negative regulation of smooth muscle cell proliferation	-
GO:0050668	IEA	-	positive regulation of homocysteine metabolic process	-
GO:0051930	IEA	-	regulation of sensory perception of pain	-

Protein-Protein Interaction

BioGRID:4 results
BIND:0 results
HPRD:0 results

Gene Symbol	Interactant	Interaction ID	References	Description
XRN2	COMT	107707	15231747	Two-hybrid
XRN2	COMT	116483	15231747	Two-hybrid
TRIP13	COMT	107707	16189514	Two-hybrid
TRIP13	COMT	114730	16189514	Two-hybrid

AlzGene, PDGene and SZGene

Alz Gene:1 results
PD Gene:1 results
SZ Gene:1 results

Gene Symbol	Poly Names	Gene overview in AlzGene
COMT	rs4680	Gene overview in AlzGene

Gene Symbol	Poly Names	Gene overview in SZGene
COMT	COMT_-137A/G, COMT_-287A/G, COMT_597G/A, D22S264, D22S446, D22S447, D22S451, D22S688, D22S705, D22S873, D22S944, D22S958, rs1012157, rs1544325, rs1548357, rs165599, rs165656, rs165722, rs165728, rs165774, rs16982844, rs17210001, rs174673, rs174675, rs174682, rs174696, rs174697, rs174699, rs1800706, rs1805052, rs2020917, rs2075507, rs2097603, rs2238794, rs2238797, rs2239393, rs2240716, rs362204, rs3788310, rs3788319, rs3810595, rs3838146, rs4633, rs4646310, rs4646312, rs4646315, rs4646316, rs4646317, rs4646318, rs4680, rs4818, rs5746849, rs5992500, rs5993882, rs5993883, rs6267, rs6269, rs6518592, rs71186636, rs7289747, rs7290221, rs737864, rs737865, rs737866, rs740601, rs740603, rs769224, rs8185002, rs885987, rs9332347, rs9332362, rs9332377, rs9332381, rs933271	Gene overview in SZGene

Animal Model

Mouse:1 results
Fruit Fly:1 results

MGI ID: MGI:88470
Data Attributes: MGI curated and HomoloGene calculated