AutismKB 2.0

Annotation Details for MAP3K8


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Basic Information Top
Gene Symbol:MAP3K8 ( COT,EST,ESTF,FLJ10486,MEKK8,TPL2,Tpl-2,c-COT )
Gene Full Name: mitogen-activated protein kinase kinase kinase 8
Band: 10p11.23
Quick LinksEntrez ID:1326; OMIM: 191195; Uniprot ID:M3K8_HUMAN; ENSEMBL ID: ENSG00000107968; HGNC ID: 6860
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IBA-cytoplasm-
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO ID Evidence Qualifier GO_term References
GO:0000287IEA-magnesium ion binding-
GO:0004674TAS-protein serine/threonine kinase activity8226782
GO:0004702IBA-signal transducer, downstream of receptor, with serine/threonine kinase activity-
GO:0004709TAS-MAP kinase kinase kinase activity-
GO:0005515IPI-protein binding12832462
GO:0005524IEA-ATP binding-
GO ID Evidence Qualifier GO_term References
GO:0000186IEA-activation of MAPKK activity-
GO:0006468TAS-protein phosphorylation2072910
GO:0007049IEA-cell cycle-
GO:0031295TAS-T cell costimulation-
GO:0051403TAS-stress-activated MAPK cascade-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MAP3K8AKT110671012138205 Affinity Capture-Western; Biochemical Activity
MAP3K8AKT110771912138205 Affinity Capture-Western; Biochemical Activity
MAP3K8CHUK10756910072079 Affinity Capture-Western; Biochemical Activity
MAP3K8CHUK10771910072079 Affinity Capture-Western; Biochemical Activity
MAP2K1MAP3K81077198631303 Biochemical Activity
MAP2K1MAP3K81115908631303 Biochemical Activity
MAP2K4MAP3K81123158631303 Biochemical Activity
MAP2K4MAP3K81077198631303 Biochemical Activity
NFKB1MAP3K81077199950430 14743216 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NFKB1MAP3K81108579950430 14743216 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MAP3K14MAP3K810771910072079 Affinity Capture-Western
MAP3K14MAP3K811448710072079 Affinity Capture-Western
TRAF2MAP3K811303811932422 Affinity Capture-RNA
TRAF2MAP3K810771911932422 Affinity Capture-RNA
KSR2MAP3K810771912975377 Affinity Capture-Western
KSR2MAP3K812956712975377 Affinity Capture-Western
NFKB2MAP3K811085814743216 Affinity Capture-MS
NFKB2MAP3K810771914743216 Affinity Capture-MS
RELMAP3K811189814743216 Affinity Capture-MS
RELMAP3K810771914743216 Affinity Capture-MS
RELAMAP3K811190214743216 Affinity Capture-MS
RELAMAP3K810771914743216 Affinity Capture-MS
TNIP2MAP3K810771914743216 Affinity Capture-MS
TNIP2MAP3K812257314743216 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1346878
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-100316-8'