AutismKB 2.0

Annotation Details for ADORA2A


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Basic Information Top
Gene Symbol:ADORA2A ( ADORA2,RDC8,hA2aR )
Gene Full Name: adenosine A2a receptor
Band: 22q11.23
Quick LinksEntrez ID:135; OMIM: 102776; Uniprot ID:AA2AR_HUMAN; ENSEMBL ID: ENSG00000100014,ENSG00000128271; HGNC ID: 263
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005882IEA-intermediate filament-
GO:0005886IDA-plasma membrane16339847
GO:0005886TAS-plasma membrane-
GO:0005887IMP-integral component of plasma membrane21393508
GO:0012505IEA-endomembrane system-
GO:0014069IEA-postsynaptic density-
GO:0016020TAS-membrane10051547
GO:0030425IEA-dendrite-
GO:0030673IEA-axolemma-
GO:0042734IEA-presynaptic membrane-
GO:0043025IEA-neuronal cell body-
GO:0045211IEA-postsynaptic membrane-
GO:0048786IEA-presynaptic active zone-
GO ID Evidence Qualifier GO_term References
GO:0001609IDA-G-protein coupled adenosine receptor activity21393508
GO:0005515IPI-protein binding11571652
GO:0019899IPI-enzyme binding16339847
GO:0031802IEA-type 5 metabotropic glutamate receptor binding-
GO:0042802IPI-identical protein binding18675812
GO:0046982IEA-protein heterodimerization activity-
GO:0051393IEA-alpha-actinin binding-
GO ID Evidence Qualifier GO_term References
GO:0001963IEA-synaptic transmission, dopaminergic-
GO:0001973IEA-adenosine receptor signaling pathway-
GO:0001975IEA-response to amphetamine-
GO:0006171TAS-cAMP biosynthetic process10899090
GO:0006355IEA-regulation of transcription, DNA-templated-
GO:0006469IEA-negative regulation of protein kinase activity-
GO:0006909TAS-phagocytosis8360491
GO:0006915TAS-apoptotic process7818494
GO:0006954TAS-inflammatory response8360491
GO:0006968TAS-cellular defense response10051547
GO:0007188TAS-adenylate cyclase-modulating G-protein coupled receptor signaling pathway10899090
GO:0007205IEA-protein kinase C-activating G-protein coupled receptor signaling pathway-
GO:0007267TAS-cell-cell signaling7818494
GO:0007271IEA-synaptic transmission, cholinergic-
GO:0007417TAS-central nervous system development10945659
GO:0007596TAS-blood coagulation10899090
GO:0007600TAS-sensory perception9262401
GO:0007626IEA-locomotory behavior-
GO:0008015TAS-blood circulation9262401
GO:0008285IEA-negative regulation of cell proliferation-
GO:0010579IDA-positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway21393508
GO:0014049IEA-positive regulation of glutamate secretion-
GO:0014057IEA-positive regulation of acetylcholine secretion, neurotransmission-
GO:0014061IEA-regulation of norepinephrine secretion-
GO:0031000IEA-response to caffeine-
GO:0032230IEA-positive regulation of synaptic transmission, GABAergic-
GO:0035249IEA-synaptic transmission, glutamatergic-
GO:0035810IEA-positive regulation of urine volume-
GO:0035815IEA-positive regulation of renal sodium excretion-
GO:0040013IEA-negative regulation of locomotion-
GO:0042311IEA-vasodilation-
GO:0042493IEA-response to drug-
GO:0042755IEA-eating behavior-
GO:0043116IEA-negative regulation of vascular permeability-
GO:0043154IEA-negative regulation of cysteine-type endopeptidase activity involved in apoptotic process-
GO:0043524IEA-negative regulation of neuron apoptotic process-
GO:0044267TAS-cellular protein metabolic process-
GO:0045938IEA-positive regulation of circadian sleep/wake cycle, sleep-
GO:0046636IEA-negative regulation of alpha-beta T cell activation-
GO:0048143IEA-astrocyte activation-
GO:0048167IEA-regulation of synaptic plasticity-
GO:0048812IEA-neuron projection morphogenesis-
GO:0050714IEA-positive regulation of protein secretion-
GO:0050728IEA-negative regulation of inflammatory response-
GO:0051881IEA-regulation of mitochondrial membrane potential-
GO:0051899IEA-membrane depolarization-
GO:0051924IEA-regulation of calcium ion transport-
GO:0051968IEA-positive regulation of synaptic transmission, glutamatergic-
GO:0060079IEA-excitatory postsynaptic potential-
GO:0060080IEA-inhibitory postsynaptic potential-
GO:0060134IEA-prepulse inhibition-
GO:2001235IEA-positive regulation of apoptotic signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ADORA2AADA10664711125033 Affinity Capture-Western
ADORA2AADA10661411125033 Affinity Capture-Western
DRD2ADORA2A10664712804599 Affinity Capture-Western; FRET
DRD2ADORA2A10814712804599 Affinity Capture-Western; FRET
ADORA2AADORA2A10664712804599 FRET
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
ADORA2Ars5751876 Gene overview in AlzGene
Gene Symbol Poly Names Gene overview in PDGene
ADORA2Ars3032740, rs5751876 Gene overview in PDGene
Gene Symbol Poly Names Gene overview in SZGene
ADORA2AADORA2A_1976T/C, rs5751876 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:99402
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-080723-28'