Annotation Details for CR1

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Basic Information Top

Gene Symbol:	CR1 ( C3BR,C4BR,CD35,KN )
Gene Full Name:	complement component (3b/4b) receptor 1 (Knops blood group)
Band:	1q32.2
Quick Links	Entrez ID:1378; OMIM: 120620; Uniprot ID:CR1_HUMAN; ENSEMBL ID: ENSG00000203710; HGNC ID: 2334
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

AlzGene, PDGene and SZGene

Gene Ontology

Cellular Component:6 results
Molecular Function:5 results
Biological Process:10 results

GO ID	Evidence	Qualifier	GO_term	References
GO:0005886	TAS	-	plasma membrane	-
GO:0005887	IDA	-	integral component of plasma membrane	6910481
GO:0009986	IDA	-	cell surface	2972794
GO:0030667	TAS	-	secretory granule membrane	-
GO:0070062	IDA	-	extracellular exosome	19056867
GO:0101003	TAS	-	ficolin-1-rich granule membrane	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0001618	IEA	-	virus receptor activity	-
GO:0001851	IDA	-	complement component C3b binding	2972794
GO:0001855	IDA	-	complement component C4b binding	2972794
GO:0001861	IDA	-	complement component C4b receptor activity	2972794
GO:0004877	IDA	-	complement component C3b receptor activity	2972794

GO ID	Evidence	Qualifier	GO_term	References
GO:0002430	IEA	-	complement receptor mediated signaling pathway	-
GO:0006958	IEA	-	complement activation, classical pathway	-
GO:0030449	TAS	-	regulation of complement activation	-
GO:0043312	TAS	-	neutrophil degranulation	-
GO:0045087	IEA	-	innate immune response	-
GO:0045957	IDA	-	negative regulation of complement activation, alternative pathway	10531307
GO:0045959	IDA	-	negative regulation of complement activation, classical pathway	6910481
GO:0046718	IEA	-	viral entry into host cell	-
GO:1900004	IDA	-	negative regulation of serine-type endopeptidase activity	6910481
GO:1900005	IDA	-	positive regulation of serine-type endopeptidase activity	2972794

Protein-Protein Interaction

BioGRID:2 results
BIND:0 results
HPRD:0 results

Gene Symbol	Interactant	Interaction ID	References	Description
CR2	CR1	107769	1708808	Affinity Capture-Western
CR2	CR1	107771	1708808	Affinity Capture-Western

AlzGene, PDGene and SZGene

Alz Gene:1 results
PD Gene:0 results
SZ Gene:0 results

Gene Symbol	Poly Names	Gene overview in AlzGene
CR1	rs11118475, rs11118491, rs1359147, rs1408077, rs17049197, rs1977265, rs1998538, rs1998539, rs2104303, rs3818361, rs3849268, rs3927459, rs4844614, rs6656401, rs6661764, rs6667500, rs6701713	Gene overview in AlzGene

Animal Model

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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