AutismKB 2.0

Annotation Details for ATF2


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Basic Information Top
Gene Symbol:ATF2 ( CRE-BP1,CREB2,HB16,MGC111558,TREB7 )
Gene Full Name: activating transcription factor 2
Band: 2q31.1
Quick LinksEntrez ID:1386; OMIM: 123811; Uniprot ID:ATF2_HUMAN; ENSEMBL ID: ENSG00000115966; HGNC ID: 784
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus8798441
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005737IDA-cytoplasm22304920
GO:0005741IDA-mitochondrial outer membrane22304920
GO:0035861IDA-site of double-strand break15916964
GO ID Evidence Qualifier GO_term References
GO:0000977IMP-RNA polymerase II regulatory region sequence-specific DNA binding2516827
GO:0000980IDA-RNA polymerase II distal enhancer sequence-specific DNA binding19861239
GO:0001076IC-transcription factor activity, RNA polymerase II transcription factor binding19861239
GO:0001077IEA-transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding-
GO:0001102IPI-RNA polymerase II activating transcription factor binding19861239
GO:0001158IDA-enhancer sequence-specific DNA binding2196176
GO:0001228IC-transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding-
GO:0003682IEA-chromatin binding-
GO:0003700IDA-transcription factor activity, sequence-specific DNA binding8798441
GO:0003705IC-transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding19861239
GO:0003713TAS-transcription coactivator activity2529117
GO:0004402IDA-histone acetyltransferase activity10821277
GO:0004402TAS-histone acetyltransferase activity-
GO:0005515IPI-protein binding8440710
GO:0008140IDA-cAMP response element binding protein binding19861239
GO:0019901IPI-protein kinase binding21098032
GO:0035497IDA-cAMP response element binding19861239
GO:0046872IEA-metal ion binding-
GO:0046982IEA-protein heterodimerization activity-
GO ID Evidence Qualifier GO_term References
GO:0000122IEA-negative regulation of transcription from RNA polymerase II promoter-
GO:0003151IEA-outflow tract morphogenesis-
GO:0006355IMP-regulation of transcription, DNA-templated22304920
GO:0006357IC-regulation of transcription from RNA polymerase II promoter19861239
GO:0006366IEA-transcription from RNA polymerase II promoter-
GO:0006970IDA-response to osmotic stress21098032
GO:0006974IDA-cellular response to DNA damage stimulus22304920
GO:0006974IMP-cellular response to DNA damage stimulus15916964
GO:0009414IEA-response to water deprivation-
GO:0016573IEA-histone acetylation-
GO:0031573IMP-intra-S DNA damage checkpoint15916964
GO:0032915IEA-positive regulation of transforming growth factor beta2 production-
GO:0043525IEA-positive regulation of neuron apoptotic process-
GO:0045444IEA-fat cell differentiation-
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter16300731
GO:0050680IEA-negative regulation of epithelial cell proliferation-
GO:0051090TAS-regulation of sequence-specific DNA binding transcription factor activity-
GO:0051091IMP-positive regulation of sequence-specific DNA binding transcription factor activity10821277
GO:0060612IEA-adipose tissue development-
GO:0097186IEA-amelogenesis-
GO:1902110IMP-positive regulation of mitochondrial membrane permeability involved in apoptotic process22304920
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ATF2ATF310695720211142 Two-hybrid
ATF2ATF310777620211142 Two-hybrid
ATF2ATM10777615916964 Biochemical Activity
ATF2ATM10696215916964 Biochemical Activity
ATF2CEBPA10777614734562 Two-hybrid
ATF2CEBPA10747914734562 Two-hybrid
ATF2CEBPB10777616303757 Affinity Capture-Western
ATF2CEBPB10748016303757 Affinity Capture-Western
RB1ATF21118601641004 Reconstituted Complex
RB1ATF21077761641004 Reconstituted Complex
JUNATF21099281827203 2320002 8027667 Affinity Capture-Western; Reconstituted Complex
JUNATF21077761827203 2320002 8027667 Affinity Capture-Western; Reconstituted Complex
FOSATF21086361827203 Reconstituted Complex
FOSATF21077761827203 Reconstituted Complex
MAPK8ATF21115857535770 9207092 9405416 11279118 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
MAPK8ATF21077767535770 9207092 9405416 11279118 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
MAPK14ATF21078197535770 9207092 11279118 Biochemical Activity; Reconstituted Complex
MAPK14ATF21077767535770 9207092 11279118 Biochemical Activity; Reconstituted Complex
MAPK1ATF21077767737129 Biochemical Activity
MAPK1ATF21115807737129 Biochemical Activity
ATF2ATF21077768027667 Affinity Capture-Western
UBE2IATF21131779488727 Far Western; Two-hybrid
UBE2IATF21077769488727 Far Western; Two-hybrid
UTF1ATF21140139524124 Reconstituted Complex; Two-hybrid
UTF1ATF21077769524124 Reconstituted Complex; Two-hybrid
CREBBPATF21077779659924 9786917 16303757 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CREBBPATF21077769659924 9786917 16303757 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PMLATF21113849671405 Reconstituted Complex
PMLATF21077769671405 Reconstituted Complex
CSNK2A1ATF21077769685505 Far Western; Reconstituted Complex
CSNK2A1ATF21078419685505 Far Western; Reconstituted Complex
CSNK2A2ATF21078429685505 Far Western; Reconstituted Complex
CSNK2A2ATF21077769685505 Far Western; Reconstituted Complex
SMAD3ATF211026310085140 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SMAD3ATF210777610085140 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SMAD4ATF211026410085140 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SMAD4ATF210777610085140 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
HMGA1ATF210940210357819 Reconstituted Complex
HMGA1ATF210777610357819 Reconstituted Complex
RUVBL2ATF211606711713276 Affinity Capture-Western
RUVBL2ATF210777611713276 Affinity Capture-Western
MAPK13ATF210777612244047 Biochemical Activity
MAPK13ATF211158912244047 Biochemical Activity
NCOA6ATF211669114734562 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NCOA6ATF210777614734562 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NBNATF211076315916964 Affinity Capture-Western; Co-localization
NBNATF210777615916964 Affinity Capture-Western; Co-localization
MRE11AATF210777615916964 Co-localization
MRE11AATF211050115916964 Co-localization
JDP2ATF212580718307971 18396163 Affinity Capture-Western; Reconstituted Complex
JDP2ATF210777618307971 18396163 Affinity Capture-Western; Reconstituted Complex
IRF2BP1ATF211757618671972 Reconstituted Complex
IRF2BP1ATF210777618671972 Reconstituted Complex
HDAC4ATF211510620116378 Affinity Capture-Western
HDAC4ATF210777620116378 Affinity Capture-Western
YY1ATF211336020211142 Two-hybrid
YY1ATF210777620211142 Two-hybrid
CCDC6ATF211372520498639 Reconstituted Complex
CCDC6ATF210777620498639 Reconstituted Complex
Gene Symbol Interactant Interaction ID References Description
ATF2ATM29590515916964 An unspecified isoform of ATM interacts with and phosphorylates ATF2.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:109349
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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