AutismKB 2.0

Annotation Details for CREM


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Basic Information Top
Gene Symbol:CREM ( ICER,MGC111110,MGC17881,MGC41893,hCREM-2 )
Gene Full Name: cAMP responsive element modulator
Band: 10p11.21
Quick LinksEntrez ID:1390; OMIM: 123812; Uniprot ID:CREM_HUMAN; ENSEMBL ID: ENSG00000095794; HGNC ID: 2352
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634NAS-nucleus8206879
GO:0005667IEA-transcription factor complex-
GO:0005737IEA-cytoplasm-
GO ID Evidence Qualifier GO_term References
GO:0000977IDA-RNA polymerase II regulatory region sequence-specific DNA binding16899810
GO:0001227IC-transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding-
GO:0003677NAS-DNA binding7916662
GO:0005515IPI-protein binding21976679
GO:0008140NAS-cAMP response element binding protein binding8206879
GO ID Evidence Qualifier GO_term References
GO:0000122IMP-negative regulation of transcription from RNA polymerase II promoter12626549
GO:0006006IEA-glucose metabolic process-
GO:0006351IEA-transcription, DNA-templated-
GO:0006355IDA-regulation of transcription, DNA-templated8206879
GO:0006355NAS-regulation of transcription, DNA-templated7916662
GO:0006631IEA-fatty acid metabolic process-
GO:0006687IEA-glycosphingolipid metabolic process-
GO:0007165TAS-signal transduction7916662
GO:0007275IEA-multicellular organism development-
GO:0007283IEA-spermatogenesis-
GO:0030154IEA-cell differentiation-
GO:0042752IEA-regulation of circadian rhythm-
GO:0045944IEA-positive regulation of transcription from RNA polymerase II promoter-
GO:0048384IEA-retinoic acid receptor signaling pathway-
GO:0048511IEA-rhythmic process-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CREMCD3410778010373550 Two-hybrid
CREMCD3410738510373550 Two-hybrid
SPI1CREM1125667730336 Reconstituted Complex
SPI1CREM1077807730336 Reconstituted Complex
FHL5CREM11484610086359 11046156 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FHL5CREM10778010086359 11046156 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TAF4CREM11273710409662 Reconstituted Complex
TAF4CREM10778010409662 Reconstituted Complex
TBPCREM10778010409662 Reconstituted Complex
TBPCREM11277110409662 Reconstituted Complex
KCNIP3CREM11904211094064 Reconstituted Complex
KCNIP3CREM10778011094064 Reconstituted Complex
CREB3L4CREM12714216595651 Affinity Capture-Western
CREB3L4CREM10778016595651 Affinity Capture-Western
HDAC1CREM10931517056544 Affinity Capture-Western; Reconstituted Complex
HDAC1CREM10778017056544 Affinity Capture-Western; Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:88495
  • Data Attributes: MGI curated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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