AutismKB 2.0

Annotation Details for CRH


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Basic Information Top
Gene Symbol:CRH ( CRF )
Gene Full Name: corticotropin releasing hormone
Band: 8q13.1
Quick LinksEntrez ID:1392; OMIM: 122560; Uniprot ID:CRF_HUMAN; ENSEMBL ID: ENSG00000147571; HGNC ID: 2355
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005615IDA-extracellular space18559919
GO:0005737IEA-cytoplasm-
GO:0043196IEA-varicosity-
GO:0043204IEA-perikaryon-
GO ID Evidence Qualifier GO_term References
GO:0005102TAS-receptor binding7477348
GO:0005179TAS-hormone activity7585095
GO:0005184TAS-neuropeptide hormone activity7867564
GO:0005515IPI-protein binding18234674
GO:0017045IBA-corticotropin-releasing hormone activity-
GO:0051430IEA-corticotropin-releasing hormone receptor 1 binding-
GO:0051431IEA-corticotropin-releasing hormone receptor 2 binding-
GO ID Evidence Qualifier GO_term References
GO:0001934IEA-positive regulation of protein phosphorylation-
GO:0001963IDA-synaptic transmission, dopaminergic12895416
GO:0006704IEA-glucocorticoid biosynthetic process-
GO:0006954IDA-inflammatory response18559919
GO:0007165TAS-signal transduction7867564
GO:0007268TAS-chemical synaptic transmission7477348
GO:0007565IDA-female pregnancy18559919
GO:0007567TAS-parturition7585095
GO:0007611TAS-learning or memory7477348
GO:0008284IEA-positive regulation of cell proliferation-
GO:0008306IEA-associative learning-
GO:0008628IEA-hormone-mediated apoptotic signaling pathway-
GO:0010628IEA-positive regulation of gene expression-
GO:0010629IEA-negative regulation of gene expression-
GO:0010700IEA-negative regulation of norepinephrine secretion-
GO:0010841NAS-positive regulation of circadian sleep/wake cycle, wakefulness18329818
GO:0010942IEA-positive regulation of cell death-
GO:0014062IEA-regulation of serotonin secretion-
GO:0016101IEA-diterpenoid metabolic process-
GO:0021854IEA-hypothalamus development-
GO:0030324IEA-lung development-
GO:0030325IEA-adrenal gland development-
GO:0030819IEA-positive regulation of cAMP biosynthetic process-
GO:0032811IEA-negative regulation of epinephrine secretion-
GO:0033685IEA-negative regulation of luteinizing hormone secretion-
GO:0035641IEA-locomotory exploration behavior-
GO:0035774IEA-positive regulation of insulin secretion involved in cellular response to glucose stimulus-
GO:0035902IEA-response to immobilization stress-
GO:0042322NAS-negative regulation of circadian sleep/wake cycle, REM sleep18329818
GO:0042493IEA-response to drug-
GO:0043627IEA-response to estrogen-
GO:0045471IEA-response to ethanol-
GO:0045472IEA-response to ether-
GO:0045776IEA-negative regulation of blood pressure-
GO:0048265IEA-response to pain-
GO:0050801IEA-ion homeostasis-
GO:0051412IEA-response to corticosterone-
GO:0051461IEA-positive regulation of corticotropin secretion-
GO:0051464IDA-positive regulation of cortisol secretion18329818
GO:0060291IEA-long-term synaptic potentiation-
GO:0060456IEA-positive regulation of digestive system process-
GO:0060548IEA-negative regulation of cell death-
GO:0070093IEA-negative regulation of glucagon secretion-
GO:0071314IEA-cellular response to cocaine-
GO:0071549IEA-cellular response to dexamethasone stimulus-
GO:0090280IEA-positive regulation of calcium ion import-
GO:2000310IDA-regulation of NMDA receptor activity12895416
GO:2000854IEA-positive regulation of corticosterone secretion-
GO:2000987IEA-positive regulation of behavioral fear response-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CRHR2CRH1077828243338 Reconstituted Complex
CRHR2CRH1077858243338 Reconstituted Complex
CRHR1CRH1077829423932 10598591 Reconstituted Complex
CRHR1CRH1077849423932 10598591 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
CRHrs6159 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:88496
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-041114-75'