AutismKB 2.0

Annotation Details for CRK


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Basic Information Top
Gene Symbol:CRK ( CRKII )
Gene Full Name: v-crk sarcoma virus CT10 oncogene homolog (avian)
Band: 17p13.3
Quick LinksEntrez ID:1398; OMIM: 164762; Uniprot ID:CRK_HUMAN; ENSEMBL ID: ENSG00000167193; HGNC ID: 2362
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634TAS-nucleus10748058
GO:0005737IC-cytoplasm11870224
GO:0005829TAS-cytosol-
GO:0005886IEA-plasma membrane-
GO:0015629IEA-actin cytoskeleton-
GO:0043234IPI-protein complex12384576
GO:0045121IEA-membrane raft-
GO:0070062IDA-extracellular exosome19056867
GO ID Evidence Qualifier GO_term References
GO:0001784IPI-phosphotyrosine residue binding20624904
GO:0005070IDA-SH3/SH2 adaptor activity12384576
GO:0005159IEA-insulin-like growth factor receptor binding-
GO:0005515IPI-protein binding7561682
GO:0008092IEA-cytoskeletal protein binding-
GO:0017124IPI-SH3 domain binding12384576
GO:0042169IPI-SH2 domain binding9472046
GO:0043621IDA-protein self-association17515907
GO:0045309IDA-protein phosphorylated amino acid binding12384576
GO:0046875IPI-ephrin receptor binding11870224
GO:0097110IEA-scaffold protein binding-
GO:1990782IPI-protein tyrosine kinase binding12384576
GO ID Evidence Qualifier GO_term References
GO:0000186TAS-activation of MAPKK activity-
GO:0001878IEA-response to yeast-
GO:0006357TAS-regulation of transcription from RNA polymerase II promoter10748058
GO:0008360IMP-regulation of cell shape17515907
GO:0009966IDA-regulation of signal transduction17515907
GO:0014911IEA-positive regulation of smooth muscle cell migration-
GO:0032956IDA-regulation of actin cytoskeleton organization11870224
GO:0035020IEA-regulation of Rac protein signal transduction-
GO:0035728IEA-response to hepatocyte growth factor-
GO:0038096TAS-Fc-gamma receptor signaling pathway involved in phagocytosis-
GO:0042542IEA-response to hydrogen peroxide-
GO:0043087IDA-regulation of GTPase activity11870224
GO:0043393IMP-regulation of protein binding17515907
GO:0045953IEA-negative regulation of natural killer cell mediated cytotoxicity-
GO:0048010TAS-vascular endothelial growth factor receptor signaling pathway-
GO:0048013IDA-ephrin receptor signaling pathway11870224
GO:0061045IDA-negative regulation of wound healing17515907
GO:0061045IMP-negative regulation of wound healing17515907
GO:0061847IEA-response to cholecystokinin-
GO:0071538IDA-SH2 domain-mediated complex assembly12384576
GO:0071560IEA-cellular response to transforming growth factor beta stimulus-
GO:0071732IEA-cellular response to nitric oxide-
GO:1900026IMP-positive regulation of substrate adhesion-dependent cell spreading19004829
GO:1990090IEA-cellular response to nerve growth factor stimulus-
GO:1990314IEA-cellular response to insulin-like growth factor stimulus-
GO:1990859IEA-cellular response to endothelin-
GO:2000146IDA-negative regulation of cell motility17515907
GO:2000146IMP-negative regulation of cell motility17515907
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CRKBUB110716416189514 Two-hybrid
CRKBUB110778816189514 Two-hybrid
CRKCBL1073159178909 9461587 Affinity Capture-Western
CRKCBL1077889178909 9461587 Affinity Capture-Western
SH3BP1CRK1171491379745 Reconstituted Complex
SH3BP1CRK1077881379745 Reconstituted Complex
KHDRBS1CRK1159001545818 Reconstituted Complex
KHDRBS1CRK1077881545818 Reconstituted Complex
RAPGEF1CRK1077887512734 Affinity Capture-Western; Far Western
RAPGEF1CRK1091467512734 Affinity Capture-Western; Far Western
EPS15CRK1083747797522 Far Western; Reconstituted Complex
EPS15CRK1077887797522 Far Western; Reconstituted Complex
DOCK1CRK1081288657152 8662907 10559471 11369773 12615911 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
DOCK1CRK1077888657152 8662907 10559471 11369773 12615911 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
GRB2CRK1077888662907 8810325 10970810 Affinity Capture-Western; Far Western; Reconstituted Complex
GRB2CRK1091428662907 8810325 10970810 Affinity Capture-Western; Far Western; Reconstituted Complex
SOS1CRK1125378810325 Affinity Capture-Western; Reconstituted Complex
SOS1CRK1077888810325 Affinity Capture-Western; Reconstituted Complex
NEDD9CRK1108168879209 9497377 Affinity Capture-Western; Reconstituted Complex
NEDD9CRK1077888879209 9497377 Affinity Capture-Western; Reconstituted Complex
NCK1CRK1107708879209 Reconstituted Complex
NCK1CRK1077888879209 Reconstituted Complex
PTPN1CRK1077888940134 Reconstituted Complex
PTPN1CRK1117368940134 Reconstituted Complex
RETCRK1119119393871 Reconstituted Complex
RETCRK1077889393871 Reconstituted Complex
PDGFRACRK1111829546424 10733900 Affinity Capture-Western; Reconstituted Complex
PDGFRACRK1077889546424 10733900 Affinity Capture-Western; Reconstituted Complex
BCAR1CRK1149349581808 9920935 10085298 10329689 10753828 11369773 12615911 14657239 15492270 16267043 Affinity Capture-Western; Reconstituted Complex
BCAR1CRK1077889581808 9920935 10085298 10329689 10753828 11369773 12615911 14657239 15492270 16267043 Affinity Capture-Western; Reconstituted Complex
IRS4CRK1077889614078 11316748 Affinity Capture-Western; Reconstituted Complex
IRS4CRK1140489614078 11316748 Affinity Capture-Western; Reconstituted Complex
EGFRCRK1077889642287 16729043 Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity
EGFRCRK1082769642287 16729043 Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity
EPHB3CRK1083639674711 Reconstituted Complex
EPHB3CRK1077889674711 Reconstituted Complex
MAP4K1CRK1163549788432 9891069 11279207 Affinity Capture-Western; Reconstituted Complex
MAP4K1CRK1077889788432 9891069 11279207 Affinity Capture-Western; Reconstituted Complex
ASAP1CRK1191269819391 Reconstituted Complex
ASAP1CRK1077889819391 Reconstituted Complex
SOCS1CRK11420310022833 Reconstituted Complex
SOCS1CRK10778810022833 Reconstituted Complex
PTK2CRK11171910085298 12615911 Affinity Capture-Western; Reconstituted Complex
PTK2CRK10778810085298 12615911 Affinity Capture-Western; Reconstituted Complex
PXNCRK10778810085298 12198159 Affinity Capture-Western; Reconstituted Complex
PXNCRK11178710085298 12198159 Affinity Capture-Western; Reconstituted Complex
FRS2CRK11603110092678 Reconstituted Complex
FRS2CRK10778810092678 Reconstituted Complex
CBLCCRK11715610362357 Reconstituted Complex
CBLCCRK10778810362357 Reconstituted Complex
ZAP70CRK11336710419455 Reconstituted Complex
ZAP70CRK10778810419455 Reconstituted Complex
EPHB2CRK10836210644995 Reconstituted Complex
EPHB2CRK10778810644995 Reconstituted Complex
MAP4K5CRK11635310648385 Affinity Capture-Western
MAP4K5CRK10778810648385 Affinity Capture-Western
PDGFRBCRK11118510733900 Affinity Capture-Western; Reconstituted Complex
PDGFRBCRK10778810733900 Affinity Capture-Western; Reconstituted Complex
KCNIP3CRK10778810854253 Affinity Capture-Western
KCNIP3CRK11904210854253 Affinity Capture-Western
SYN1CRK11271910899172 Affinity Capture-Western
SYN1CRK10778810899172 Affinity Capture-Western
SHBCRK11235810964504 Affinity Capture-Western
SHBCRK10778810964504 Affinity Capture-Western
SH3KBP1CRK11902911071869 Affinity Capture-Western
SH3KBP1CRK10778811071869 Affinity Capture-Western
AVILCRK11591811287316 Reconstituted Complex
AVILCRK10778811287316 Reconstituted Complex
ARHGAP17CRK12042411431473 Reconstituted Complex
ARHGAP17CRK10778811431473 Reconstituted Complex
MAPK8CRK11158511432831 Affinity Capture-Western; Reconstituted Complex
MAPK8CRK10778811432831 Affinity Capture-Western; Reconstituted Complex
MICAL1CRK12229011827972 Reconstituted Complex
MICAL1CRK10778811827972 Reconstituted Complex
WEE1CRK11330311839808 Affinity Capture-Western
WEE1CRK10778811839808 Affinity Capture-Western
XPO1CRK10778811839808 Two-hybrid
XPO1CRK11334811839808 Two-hybrid
EPHA3CRK10835611870224 Affinity Capture-Western
EPHA3CRK10778811870224 Affinity Capture-Western
ARHGAP32CRK11509112454018 12819203 Affinity Capture-Western; Reconstituted Complex
ARHGAP32CRK10778812454018 12819203 Affinity Capture-Western; Reconstituted Complex
SRCCRK11259212615911 Affinity Capture-Western
SRCCRK10778812615911 Affinity Capture-Western
SRCIN1CRK12327514657239 Affinity Capture-Western
SRCIN1CRK10778814657239 Affinity Capture-Western
PLSCR1CRK11137316189514 Two-hybrid
PLSCR1CRK10778816189514 Two-hybrid
DPPA4CRK12050716189514 Two-hybrid
DPPA4CRK10778816189514 Two-hybrid
PSMC6CRK10778816189514 Two-hybrid
PSMC6CRK11167916189514 Two-hybrid
ERBB4CRK10778816729043 Affinity Capture-MS
ERBB4CRK10837816729043 Affinity Capture-MS
Gene Symbol Interactant Interaction ID References Description
CRKABL229560015886098 Abl2 phosphorylates CRK. This interaction was modeled on a demonstrated interaction between ABL2 from an unspecified species and human CRK.
VAV2CRK3007378621483 Crk interacts with Vav.
ARHGAP32CRK18266812819203 Crk interacts with GC-GAP. This interaction was modelled on a demonstrated interaction between Crk from an unspecified species and human GC-GAP.
DOK4CRK18553112730241 IRS5/DOK4 interacts with Crk. This interaction was modelled on a demonstrated interaction between human IRS5/DOK4 and hamster Crk.
ASAP1CRK21790915719014 DDEF1 (AMAP1) interacts with an unspecified isoform of CRK (Crk II).
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:88508
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040801-148'