Annotation Details for CRK


Gene Symbol: | CRK ( CRKII ) |
---|---|
Gene Full Name: | v-crk sarcoma virus CT10 oncogene homolog (avian) |
Band: | 17p13.3 |
Quick Links | Entrez ID:1398; OMIM: 164762; Uniprot ID:CRK_HUMAN; ENSEMBL ID: ENSG00000167193; HGNC ID: 2362 |
Relate to Another Database: | SFARIGene; denovo-db |
GO ID | Evidence | Qualifier | GO_term | References |
---|---|---|---|---|
GO:0005634 | TAS | - | nucleus | 10748058 |
GO:0005737 | IC | - | cytoplasm | 11870224 |
GO:0005829 | TAS | - | cytosol | - |
GO:0005886 | IEA | - | plasma membrane | - |
GO:0015629 | IEA | - | actin cytoskeleton | - |
GO:0043234 | IPI | - | protein complex | 12384576 |
GO:0045121 | IEA | - | membrane raft | - |
GO:0070062 | IDA | - | extracellular exosome | 19056867 |
GO ID | Evidence | Qualifier | GO_term | References |
---|---|---|---|---|
GO:0001784 | IPI | - | phosphotyrosine residue binding | 20624904 |
GO:0005070 | IDA | - | SH3/SH2 adaptor activity | 12384576 |
GO:0005159 | IEA | - | insulin-like growth factor receptor binding | - |
GO:0005515 | IPI | - | protein binding | 7561682 |
GO:0008092 | IEA | - | cytoskeletal protein binding | - |
GO:0017124 | IPI | - | SH3 domain binding | 12384576 |
GO:0042169 | IPI | - | SH2 domain binding | 9472046 |
GO:0043621 | IDA | - | protein self-association | 17515907 |
GO:0045309 | IDA | - | protein phosphorylated amino acid binding | 12384576 |
GO:0046875 | IPI | - | ephrin receptor binding | 11870224 |
GO:0097110 | IEA | - | scaffold protein binding | - |
GO:1990782 | IPI | - | protein tyrosine kinase binding | 12384576 |
GO ID | Evidence | Qualifier | GO_term | References |
---|---|---|---|---|
GO:0000186 | TAS | - | activation of MAPKK activity | - |
GO:0001878 | IEA | - | response to yeast | - |
GO:0006357 | TAS | - | regulation of transcription from RNA polymerase II promoter | 10748058 |
GO:0008360 | IMP | - | regulation of cell shape | 17515907 |
GO:0009966 | IDA | - | regulation of signal transduction | 17515907 |
GO:0014911 | IEA | - | positive regulation of smooth muscle cell migration | - |
GO:0032956 | IDA | - | regulation of actin cytoskeleton organization | 11870224 |
GO:0035020 | IEA | - | regulation of Rac protein signal transduction | - |
GO:0035728 | IEA | - | response to hepatocyte growth factor | - |
GO:0038096 | TAS | - | Fc-gamma receptor signaling pathway involved in phagocytosis | - |
GO:0042542 | IEA | - | response to hydrogen peroxide | - |
GO:0043087 | IDA | - | regulation of GTPase activity | 11870224 |
GO:0043393 | IMP | - | regulation of protein binding | 17515907 |
GO:0045953 | IEA | - | negative regulation of natural killer cell mediated cytotoxicity | - |
GO:0048010 | TAS | - | vascular endothelial growth factor receptor signaling pathway | - |
GO:0048013 | IDA | - | ephrin receptor signaling pathway | 11870224 |
GO:0061045 | IDA | - | negative regulation of wound healing | 17515907 |
GO:0061045 | IMP | - | negative regulation of wound healing | 17515907 |
GO:0061847 | IEA | - | response to cholecystokinin | - |
GO:0071538 | IDA | - | SH2 domain-mediated complex assembly | 12384576 |
GO:0071560 | IEA | - | cellular response to transforming growth factor beta stimulus | - |
GO:0071732 | IEA | - | cellular response to nitric oxide | - |
GO:1900026 | IMP | - | positive regulation of substrate adhesion-dependent cell spreading | 19004829 |
GO:1990090 | IEA | - | cellular response to nerve growth factor stimulus | - |
GO:1990314 | IEA | - | cellular response to insulin-like growth factor stimulus | - |
GO:1990859 | IEA | - | cellular response to endothelin | - |
GO:2000146 | IDA | - | negative regulation of cell motility | 17515907 |
GO:2000146 | IMP | - | negative regulation of cell motility | 17515907 |
Gene Symbol | Interactant | Interaction ID | References | Description |
---|---|---|---|---|
CRK | BUB1 | 107164 | 16189514 | Two-hybrid |
CRK | BUB1 | 107788 | 16189514 | Two-hybrid |
CRK | CBL | 107315 | 9178909 9461587 | Affinity Capture-Western |
CRK | CBL | 107788 | 9178909 9461587 | Affinity Capture-Western |
SH3BP1 | CRK | 117149 | 1379745 | Reconstituted Complex |
SH3BP1 | CRK | 107788 | 1379745 | Reconstituted Complex |
KHDRBS1 | CRK | 115900 | 1545818 | Reconstituted Complex |
KHDRBS1 | CRK | 107788 | 1545818 | Reconstituted Complex |
RAPGEF1 | CRK | 107788 | 7512734 | Affinity Capture-Western; Far Western |
RAPGEF1 | CRK | 109146 | 7512734 | Affinity Capture-Western; Far Western |
EPS15 | CRK | 108374 | 7797522 | Far Western; Reconstituted Complex |
EPS15 | CRK | 107788 | 7797522 | Far Western; Reconstituted Complex |
DOCK1 | CRK | 108128 | 8657152 8662907 10559471 11369773 12615911 | Affinity Capture-Western; Co-fractionation; Reconstituted Complex |
DOCK1 | CRK | 107788 | 8657152 8662907 10559471 11369773 12615911 | Affinity Capture-Western; Co-fractionation; Reconstituted Complex |
GRB2 | CRK | 107788 | 8662907 8810325 10970810 | Affinity Capture-Western; Far Western; Reconstituted Complex |
GRB2 | CRK | 109142 | 8662907 8810325 10970810 | Affinity Capture-Western; Far Western; Reconstituted Complex |
SOS1 | CRK | 112537 | 8810325 | Affinity Capture-Western; Reconstituted Complex |
SOS1 | CRK | 107788 | 8810325 | Affinity Capture-Western; Reconstituted Complex |
NEDD9 | CRK | 110816 | 8879209 9497377 | Affinity Capture-Western; Reconstituted Complex |
NEDD9 | CRK | 107788 | 8879209 9497377 | Affinity Capture-Western; Reconstituted Complex |
NCK1 | CRK | 110770 | 8879209 | Reconstituted Complex |
NCK1 | CRK | 107788 | 8879209 | Reconstituted Complex |
PTPN1 | CRK | 107788 | 8940134 | Reconstituted Complex |
PTPN1 | CRK | 111736 | 8940134 | Reconstituted Complex |
RET | CRK | 111911 | 9393871 | Reconstituted Complex |
RET | CRK | 107788 | 9393871 | Reconstituted Complex |
PDGFRA | CRK | 111182 | 9546424 10733900 | Affinity Capture-Western; Reconstituted Complex |
PDGFRA | CRK | 107788 | 9546424 10733900 | Affinity Capture-Western; Reconstituted Complex |
BCAR1 | CRK | 114934 | 9581808 9920935 10085298 10329689 10753828 11369773 12615911 14657239 15492270 16267043 | Affinity Capture-Western; Reconstituted Complex |
BCAR1 | CRK | 107788 | 9581808 9920935 10085298 10329689 10753828 11369773 12615911 14657239 15492270 16267043 | Affinity Capture-Western; Reconstituted Complex |
IRS4 | CRK | 107788 | 9614078 11316748 | Affinity Capture-Western; Reconstituted Complex |
IRS4 | CRK | 114048 | 9614078 11316748 | Affinity Capture-Western; Reconstituted Complex |
EGFR | CRK | 107788 | 9642287 16729043 | Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity |
EGFR | CRK | 108276 | 9642287 16729043 | Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity |
EPHB3 | CRK | 108363 | 9674711 | Reconstituted Complex |
EPHB3 | CRK | 107788 | 9674711 | Reconstituted Complex |
MAP4K1 | CRK | 116354 | 9788432 9891069 11279207 | Affinity Capture-Western; Reconstituted Complex |
MAP4K1 | CRK | 107788 | 9788432 9891069 11279207 | Affinity Capture-Western; Reconstituted Complex |
ASAP1 | CRK | 119126 | 9819391 | Reconstituted Complex |
ASAP1 | CRK | 107788 | 9819391 | Reconstituted Complex |
SOCS1 | CRK | 114203 | 10022833 | Reconstituted Complex |
SOCS1 | CRK | 107788 | 10022833 | Reconstituted Complex |
PTK2 | CRK | 111719 | 10085298 12615911 | Affinity Capture-Western; Reconstituted Complex |
PTK2 | CRK | 107788 | 10085298 12615911 | Affinity Capture-Western; Reconstituted Complex |
PXN | CRK | 107788 | 10085298 12198159 | Affinity Capture-Western; Reconstituted Complex |
PXN | CRK | 111787 | 10085298 12198159 | Affinity Capture-Western; Reconstituted Complex |
FRS2 | CRK | 116031 | 10092678 | Reconstituted Complex |
FRS2 | CRK | 107788 | 10092678 | Reconstituted Complex |
CBLC | CRK | 117156 | 10362357 | Reconstituted Complex |
CBLC | CRK | 107788 | 10362357 | Reconstituted Complex |
ZAP70 | CRK | 113367 | 10419455 | Reconstituted Complex |
ZAP70 | CRK | 107788 | 10419455 | Reconstituted Complex |
EPHB2 | CRK | 108362 | 10644995 | Reconstituted Complex |
EPHB2 | CRK | 107788 | 10644995 | Reconstituted Complex |
MAP4K5 | CRK | 116353 | 10648385 | Affinity Capture-Western |
MAP4K5 | CRK | 107788 | 10648385 | Affinity Capture-Western |
PDGFRB | CRK | 111185 | 10733900 | Affinity Capture-Western; Reconstituted Complex |
PDGFRB | CRK | 107788 | 10733900 | Affinity Capture-Western; Reconstituted Complex |
KCNIP3 | CRK | 107788 | 10854253 | Affinity Capture-Western |
KCNIP3 | CRK | 119042 | 10854253 | Affinity Capture-Western |
SYN1 | CRK | 112719 | 10899172 | Affinity Capture-Western |
SYN1 | CRK | 107788 | 10899172 | Affinity Capture-Western |
SHB | CRK | 112358 | 10964504 | Affinity Capture-Western |
SHB | CRK | 107788 | 10964504 | Affinity Capture-Western |
SH3KBP1 | CRK | 119029 | 11071869 | Affinity Capture-Western |
SH3KBP1 | CRK | 107788 | 11071869 | Affinity Capture-Western |
AVIL | CRK | 115918 | 11287316 | Reconstituted Complex |
AVIL | CRK | 107788 | 11287316 | Reconstituted Complex |
ARHGAP17 | CRK | 120424 | 11431473 | Reconstituted Complex |
ARHGAP17 | CRK | 107788 | 11431473 | Reconstituted Complex |
MAPK8 | CRK | 111585 | 11432831 | Affinity Capture-Western; Reconstituted Complex |
MAPK8 | CRK | 107788 | 11432831 | Affinity Capture-Western; Reconstituted Complex |
MICAL1 | CRK | 122290 | 11827972 | Reconstituted Complex |
MICAL1 | CRK | 107788 | 11827972 | Reconstituted Complex |
WEE1 | CRK | 113303 | 11839808 | Affinity Capture-Western |
WEE1 | CRK | 107788 | 11839808 | Affinity Capture-Western |
XPO1 | CRK | 107788 | 11839808 | Two-hybrid |
XPO1 | CRK | 113348 | 11839808 | Two-hybrid |
EPHA3 | CRK | 108356 | 11870224 | Affinity Capture-Western |
EPHA3 | CRK | 107788 | 11870224 | Affinity Capture-Western |
ARHGAP32 | CRK | 115091 | 12454018 12819203 | Affinity Capture-Western; Reconstituted Complex |
ARHGAP32 | CRK | 107788 | 12454018 12819203 | Affinity Capture-Western; Reconstituted Complex |
SRC | CRK | 112592 | 12615911 | Affinity Capture-Western |
SRC | CRK | 107788 | 12615911 | Affinity Capture-Western |
SRCIN1 | CRK | 123275 | 14657239 | Affinity Capture-Western |
SRCIN1 | CRK | 107788 | 14657239 | Affinity Capture-Western |
PLSCR1 | CRK | 111373 | 16189514 | Two-hybrid |
PLSCR1 | CRK | 107788 | 16189514 | Two-hybrid |
DPPA4 | CRK | 120507 | 16189514 | Two-hybrid |
DPPA4 | CRK | 107788 | 16189514 | Two-hybrid |
PSMC6 | CRK | 107788 | 16189514 | Two-hybrid |
PSMC6 | CRK | 111679 | 16189514 | Two-hybrid |
ERBB4 | CRK | 107788 | 16729043 | Affinity Capture-MS |
ERBB4 | CRK | 108378 | 16729043 | Affinity Capture-MS |
Gene Symbol | Interactant | Interaction ID | References | Description |
---|---|---|---|---|
CRK | ABL2 | 295600 | 15886098 | Abl2 phosphorylates CRK. This interaction was modeled on a demonstrated interaction between ABL2 from an unspecified species and human CRK. |
VAV2 | CRK | 300737 | 8621483 | Crk interacts with Vav. |
ARHGAP32 | CRK | 182668 | 12819203 | Crk interacts with GC-GAP. This interaction was modelled on a demonstrated interaction between Crk from an unspecified species and human GC-GAP. |
DOK4 | CRK | 185531 | 12730241 | IRS5/DOK4 interacts with Crk. This interaction was modelled on a demonstrated interaction between human IRS5/DOK4 and hamster Crk. |
ASAP1 | CRK | 217909 | 15719014 | DDEF1 (AMAP1) interacts with an unspecified isoform of CRK (Crk II). |
No data |
- MGI ID: MGI:88508
- Data Attributes: MGI curated and HomoloGene calculated
- ZFIN ID: ZDB-GENE-040801-148