AutismKB 2.0

Annotation Details for CRKL


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CRKL ( - )
Gene Full Name: v-crk sarcoma virus CT10 oncogene homolog (avian)-like
Band: 22q11.21
Quick LinksEntrez ID:1399; OMIM: 602007; Uniprot ID:CRKL_HUMAN; ENSEMBL ID: ENSG00000099942; HGNC ID: 2363
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005768TAS-endosome-
GO:0005829TAS-cytosol-
GO:0070062IDA-extracellular exosome23376485
GO ID Evidence Qualifier GO_term References
GO:0001784IPI-phosphotyrosine residue binding20624904
GO:0003723IDA-RNA binding22658674
GO:0004871TAS-signal transducer activity8361759
GO:0005070TAS-SH3/SH2 adaptor activity8798523
GO:0005515IPI-protein binding8626543
GO:0045296IDA-cadherin binding25468996
GO ID Evidence Qualifier GO_term References
GO:0000186TAS-activation of MAPKK activity-
GO:0001568IEA-blood vessel development-
GO:0007254TAS-JNK cascade8798523
GO:0007265TAS-Ras protein signal transduction8798523
GO:0007507IEA-heart development-
GO:0008284IMP-positive regulation of cell proliferation25540073
GO:0009887IEA-animal organ morphogenesis-
GO:0009952IEA-anterior/posterior pattern specification-
GO:0035556TAS-intracellular signal transduction8361759
GO:0048538IEA-thymus development-
GO:0060017IEA-parathyroid gland development-
GO:1900026IMP-positive regulation of substrate adhesion-dependent cell spreading19004829
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CRKLABL11065437926767 8978305 9820532 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CRKLABL11077897926767 8978305 9820532 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CRKLANK310778910907644 Affinity Capture-Western
CRKLANK310678510907644 Affinity Capture-Western
CRKLBCR1070838978305 9747873 10194128 15143164 Affinity Capture-Western; Far Western; Two-hybrid
CRKLBCR1077898978305 9747873 10194128 15143164 Affinity Capture-Western; Far Western; Two-hybrid
CRKLCBL1073159092574 9162067 9344843 9461587 9590251 9820532 10204582 10907644 11133830 12244174 15107835 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
CRKLCBL1077899092574 9162067 9344843 9461587 9590251 9820532 10204582 10907644 11133830 12244174 15107835 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
CRKLCBLB10778910022120 Affinity Capture-Western
CRKLCBLB10731610022120 Affinity Capture-Western
CRKLCD3410778911389015 Affinity Capture-Western; Reconstituted Complex
CRKLCD3410738511389015 Affinity Capture-Western; Reconstituted Complex
PXNCRKL1077897493940 11463817 Affinity Capture-Western; Reconstituted Complex
PXNCRKL1117877493940 11463817 Affinity Capture-Western; Reconstituted Complex
RAPGEF1CRKL1091468621483 9344843 9374471 9820532 10753869 11167825 11466412 Affinity Capture-Western; Reconstituted Complex
RAPGEF1CRKL1077898621483 9344843 9374471 9820532 10753869 11167825 11466412 Affinity Capture-Western; Reconstituted Complex
BCAR1CRKL1077898810278 9498705 Affinity Capture-Western; Far Western
BCAR1CRKL1149348810278 9498705 Affinity Capture-Western; Far Western
NEDD9CRKL1108169020138 9162067 9498705 9820532 Affinity Capture-Western; Reconstituted Complex
NEDD9CRKL1077899020138 9162067 9498705 9820532 Affinity Capture-Western; Reconstituted Complex
PIK3R2CRKL1077899092574 Affinity Capture-Western; Far Western
PIK3R2CRKL1113149092574 Affinity Capture-Western; Far Western
KITCRKL1077899092574 11071635 Affinity Capture-Western; Reconstituted Complex
KITCRKL1100159092574 11071635 Affinity Capture-Western; Reconstituted Complex
PTPN11CRKL1117459344843 Affinity Capture-Western
PTPN11CRKL1077899344843 Affinity Capture-Western
SHC1CRKL1077899344843 Affinity Capture-Western
SHC1CRKL1123619344843 Affinity Capture-Western
EPORCRKL1083719344843 11443118 Affinity Capture-Western; Reconstituted Complex
EPORCRKL1077899344843 11443118 Affinity Capture-Western; Reconstituted Complex
TYK2CRKL1077899374471 Affinity Capture-Western
TYK2CRKL1131489374471 Affinity Capture-Western
PIK3R1CRKL1077899461587 Affinity Capture-Western
PIK3R1CRKL1113139461587 Affinity Capture-Western
PDGFRACRKL1077899546424 Affinity Capture-Western
PDGFRACRKL1111829546424 Affinity Capture-Western
IRS4CRKL1077899614078 Reconstituted Complex
IRS4CRKL1140489614078 Reconstituted Complex
MAP4K1CRKL1077899788432 9891069 11279207 Affinity Capture-Western; Reconstituted Complex
MAP4K1CRKL1163549788432 9891069 11279207 Affinity Capture-Western; Reconstituted Complex
FCGR1ACRKL1077899820532 Affinity Capture-Western
FCGR1ACRKL1085039820532 Affinity Capture-Western
STAT5ACRKL1077899837784 Affinity Capture-Western; Reconstituted Complex
STAT5ACRKL1126539837784 Affinity Capture-Western; Reconstituted Complex
GRB2CRKL10914210477741 Affinity Capture-Western
GRB2CRKL10778910477741 Affinity Capture-Western
MAP4K5CRKL10778910648385 Affinity Capture-Western; Reconstituted Complex
MAP4K5CRKL11635310648385 Affinity Capture-Western; Reconstituted Complex
GAB1CRKL10882410753869 Affinity Capture-Western
GAB1CRKL10778910753869 Affinity Capture-Western
GAB2CRKL10778910871282 11334882 Affinity Capture-Western; Protein-peptide; Two-hybrid
GAB2CRKL11518110871282 11334882 Affinity Capture-Western; Protein-peptide; Two-hybrid
DOK1CRKL10778911071635 Reconstituted Complex
DOK1CRKL10813111071635 Reconstituted Complex
SYKCRKL10778911313252 Affinity Capture-Western; Reconstituted Complex
SYKCRKL11271711313252 Affinity Capture-Western; Reconstituted Complex
WASCRKL10778911313252 Affinity Capture-Western; Reconstituted Complex
WASCRKL11329311313252 Affinity Capture-Western; Reconstituted Complex
INPP5DCRKL10984711443118 Affinity Capture-Western; Reconstituted Complex
INPP5DCRKL10778911443118 Affinity Capture-Western; Reconstituted Complex
BLNKCRKL11889411489945 Affinity Capture-Western
BLNKCRKL10778911489945 Affinity Capture-Western
DOCK2CRKL10778912393632 Affinity Capture-Western
DOCK2CRKL10812912393632 Affinity Capture-Western
ARHGAP32CRKL11509112446789 Affinity Capture-Western; Reconstituted Complex
ARHGAP32CRKL10778912446789 Affinity Capture-Western; Reconstituted Complex
ETV6CRKL10778915143164 Affinity Capture-Western
ETV6CRKL10842115143164 Affinity Capture-Western
USP7CRKL10778919615732 Affinity Capture-MS
USP7CRKL11362219615732 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:104686
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-2951'