AutismKB 2.0

Annotation Details for PARP1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PARP1 ( ADPRT,ADPRT 1,ADPRT1,PARP,PARP-1,PPOL,pADPRT-1 )
Gene Full Name: poly (ADP-ribose) polymerase 1
Band: 1q42.12
Quick LinksEntrez ID:142; OMIM: 173870; Uniprot ID:PARP1_HUMAN; ENSEMBL ID: ENSG00000143799; HGNC ID: 270
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000784IDA-nuclear chromosome, telomeric region19135898
GO:0005634IDA-nucleus17177976
GO:0005635IDA-nuclear envelope9518481
GO:0005654TAS-nucleoplasm-
GO:0005667IDA-transcription factor complex19303849
GO:0005730IDA-nucleolus9518481
GO:0005739IDA-mitochondrion25378300
GO:0016020IDA-membrane19946888
GO:0032993IDA-protein-DNA complex22504299
GO:0043234IDA-protein complex22504299
GO ID Evidence Qualifier GO_term References
GO:0003677IEA-DNA binding-
GO:0003723IDA-RNA binding22658674
GO:0003910IBA-DNA ligase (ATP) activity-
GO:0003950IDA-NAD+ ADP-ribosyltransferase activity16107709
GO:0003950IMP-NAD+ ADP-ribosyltransferase activity22504299
GO:0003950TAS-NAD+ ADP-ribosyltransferase activity-
GO:0005515IPI-protein binding9518481
GO:0008134IPI-transcription factor binding19303849
GO:0008270IEA-zinc ion binding-
GO:0019899IPI-enzyme binding23382074
GO:0019901IPI-protein kinase binding17177976
GO:0030331IEA-estrogen receptor binding-
GO:0042802IPI-identical protein binding14734561
GO:0042826IEA-histone deacetylase binding-
GO:0047485IPI-protein N-terminus binding16107709
GO:0051287IEA-NAD binding-
GO:0070412IEA-R-SMAD binding-
GO:1990404IDA-protein ADP-ribosylase activity28190768
GO ID Evidence Qualifier GO_term References
GO:0000122TAS-negative regulation of transcription from RNA polymerase II promoter-
GO:0000715TAS-nucleotide-excision repair, DNA damage recognition-
GO:0000717TAS-nucleotide-excision repair, DNA duplex unwinding-
GO:0000723TAS-telomere maintenance25749521
GO:0000724TAS-double-strand break repair via homologous recombination-
GO:0006273IBA-lagging strand elongation-
GO:0006281TAS-DNA repair17396150
GO:0006293TAS-nucleotide-excision repair, preincision complex stabilization-
GO:0006294TAS-nucleotide-excision repair, preincision complex assembly-
GO:0006295TAS-nucleotide-excision repair, DNA incision, 3'-to lesion-
GO:0006296TAS-nucleotide-excision repair, DNA incision, 5'-to lesion-
GO:0006302IMP-double-strand break repair23230272
GO:0006366TAS-transcription from RNA polymerase II promoter10944198
GO:0006471IDA-protein ADP-ribosylation17396150
GO:0006471IMP-protein ADP-ribosylation22504299
GO:0006974IMP-cellular response to DNA damage stimulus24550317
GO:0007005IMP-mitochondrion organization25378300
GO:0007179IEA-transforming growth factor beta receptor signaling pathway-
GO:0010332IEA-response to gamma radiation-
GO:0010613ISS-positive regulation of cardiac muscle hypertrophy-
GO:0010990IEA-regulation of SMAD protein complex assembly-
GO:0016540IEA-protein autoprocessing-
GO:0018312IDA-peptidyl-serine ADP-ribosylation28190768
GO:0023019IEA-signal transduction involved in regulation of gene expression-
GO:0030225TAS-macrophage differentiation18309324
GO:0032042IMP-mitochondrial DNA metabolic process25378300
GO:0032869IDA-cellular response to insulin stimulus19303849
GO:0033148IEA-positive regulation of intracellular estrogen receptor signaling pathway-
GO:0033683TAS-nucleotide-excision repair, DNA incision-
GO:0034599IMP-cellular response to oxidative stress25378300
GO:0036211IMP-protein modification process25378300
GO:0042769IEA-DNA damage response, detection of DNA damage-
GO:0043504IMP-mitochondrial DNA repair25378300
GO:0044030IEA-regulation of DNA methylation-
GO:0045944IEA-positive regulation of transcription from RNA polymerase II promoter-
GO:0050790IDA-regulation of catalytic activity25749521
GO:0051103IBA-DNA ligation involved in DNA repair-
GO:0051901IEA-positive regulation of mitochondrial depolarization-
GO:0060391IEA-positive regulation of SMAD protein import into nucleus-
GO:0070212IDA-protein poly-ADP-ribosylation15674325
GO:0070911TAS-global genome nucleotide-excision repair-
GO:0071294IEA-cellular response to zinc ion-
GO:1901216IEA-positive regulation of neuron death-
GO:1903376IEA-regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway-
GO:1903827IMP-regulation of cellular protein localization24550317
GO:1904044IEA-response to aldosterone-
GO:1904357ISS-negative regulation of telomere maintenance via telomere lengthening-
GO:1904646IEA-cellular response to amyloid-beta-
GO:1904762IEA-positive regulation of myofibroblast differentiation-
GO:1990966IDA-ATP generation from poly-ADP-D-ribose27257257
GO:2000679IEA-positive regulation of transcription regulatory region DNA binding-
GO:2001170IMP-negative regulation of ATP biosynthetic process24289924
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
POLA2PARP11066529518481 Affinity Capture-Western; Far Western
POLA2PARP11171769518481 Affinity Capture-Western; Far Western
POLA1PARP11066529518481 Affinity Capture-Western; Far Western
POLA1PARP11114189518481 Affinity Capture-Western; Far Western
TP53PARP11130109565608 15044383 Affinity Capture-Western; Far Western
TP53PARP11066529565608 15044383 Affinity Capture-Western; Far Western
XRCC1PARP11066529584196 15044383 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
XRCC1PARP11133499584196 15044383 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SWAP70PARP11167079642267 Co-purification
SWAP70PARP11066529642267 Co-purification
XRCC6PARP110665210400681 16794079 Affinity Capture-Western; Reconstituted Complex
XRCC6PARP110882210400681 16794079 Affinity Capture-Western; Reconstituted Complex
XRCC5PARP110665210400681 16794079 Affinity Capture-Western; Reconstituted Complex
XRCC5PARP111335310400681 16794079 Affinity Capture-Western; Reconstituted Complex
MYBL2PARP110665210744766 Affinity Capture-Western; Reconstituted Complex
MYBL2PARP111069010744766 Affinity Capture-Western; Reconstituted Complex
RBM14PARP110665211443112 Affinity Capture-Western
RBM14PARP111570011443112 Affinity Capture-Western
RELAPARP111190211590148 16204234 18280497 Affinity Capture-Western; Reconstituted Complex
RELAPARP110665211590148 16204234 18280497 Affinity Capture-Western; Reconstituted Complex
BCL2PARP110665211790116 Reconstituted Complex
BCL2PARP110706811790116 Reconstituted Complex
RPS3APARP110665211790116 Reconstituted Complex
RPS3APARP111210311790116 Reconstituted Complex
PARP2PARP110665211948190 Affinity Capture-Western
PARP2PARP111535011948190 Affinity Capture-Western
CENPAPARP110665212011073 Affinity Capture-Western
CENPAPARP110748712011073 Affinity Capture-Western
CENPBPARP110665212011073 Affinity Capture-Western
CENPBPARP110748812011073 Affinity Capture-Western
BUB3PARP111462112011073 Affinity Capture-Western
BUB3PARP110665212011073 Affinity Capture-Western
NCOA6PARP110665212519782 Affinity Capture-MS
NCOA6PARP111669112519782 Affinity Capture-MS
PARP3PARP110665212640039 Affinity Capture-Western
PARP3PARP111535112640039 Affinity Capture-Western
PCNAPARP110665212930846 Affinity Capture-Western
PCNAPARP111114212930846 Affinity Capture-Western
CDKN1APARP110665212930846 Reconstituted Complex
CDKN1APARP110746012930846 Reconstituted Complex
ZNF423PARP111671814623329 Affinity Capture-Western; Two-hybrid
ZNF423PARP110665214623329 Affinity Capture-Western; Two-hybrid
APTXPARP112019115044383 15555565 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
APTXPARP110665215044383 15555565 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TERF2IPPARP110665215100233 Affinity Capture-MS
TERF2IPPARP111994215100233 Affinity Capture-MS
PARP1PARP110665215737996 16204234 Biochemical Activity; Reconstituted Complex
RARAPARP111184915808511 Affinity Capture-Western
RARAPARP110665215808511 Affinity Capture-Western
THRAPARP110665215808511 Affinity Capture-Western
THRAPARP111292315808511 Affinity Capture-Western
MED6PARP111531915808511 16204234 Affinity Capture-Western; Reconstituted Complex
MED6PARP110665215808511 16204234 Affinity Capture-Western; Reconstituted Complex
CDK8PARP110665215808511 16204234 Affinity Capture-Western; Reconstituted Complex
CDK8PARP110745815808511 16204234 Affinity Capture-Western; Reconstituted Complex
MED1PARP110665216204234 Affinity Capture-Western
MED1PARP111146516204234 Affinity Capture-Western
MED23PARP110665216204234 Affinity Capture-Western
MED23PARP111482916204234 Affinity Capture-Western
MED17PARP110665216204234 Affinity Capture-Western
MED17PARP111483016204234 Affinity Capture-Western
MED7PARP110665216204234 Affinity Capture-Western
MED7PARP111483316204234 Affinity Capture-Western
MED24PARP111519616204234 Affinity Capture-Western
MED24PARP110665216204234 Affinity Capture-Western
THRAP3PARP110665216204234 Affinity Capture-Western
THRAP3PARP111529216204234 Affinity Capture-Western
EP300PARP110834716204234 18280497 19622798 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
EP300PARP110665216204234 18280497 19622798 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
GTF2F1PARP110921716204234 Affinity Capture-Western; Reconstituted Complex
GTF2F1PARP110665216204234 Affinity Capture-Western; Reconstituted Complex
HDAC1PARP110665216204234 Affinity Capture-Western; Reconstituted Complex
HDAC1PARP110931516204234 Affinity Capture-Western; Reconstituted Complex
HDAC2PARP110665216204234 Affinity Capture-Western; Reconstituted Complex
HDAC2PARP110931616204234 Affinity Capture-Western; Reconstituted Complex
HDAC3PARP111436816204234 Affinity Capture-Western; Reconstituted Complex
HDAC3PARP110665216204234 Affinity Capture-Western; Reconstituted Complex
MED14PARP110665216204234 Affinity Capture-Western; Reconstituted Complex
MED14PARP111469916204234 Affinity Capture-Western; Reconstituted Complex
CREBBPPARP110665216204234 Biochemical Activity
CREBBPPARP110777716204234 Biochemical Activity
HMGA1PARP110665216204234 Reconstituted Complex
HMGA1PARP110940216204234 Reconstituted Complex
NFKB1PARP110665216204234 Reconstituted Complex
NFKB1PARP111085716204234 Reconstituted Complex
TAL1PARP110665216407974 Affinity Capture-MS
TAL1PARP111274916407974 Affinity Capture-MS
BUB1BPARP110665216449973 Affinity Capture-MS; Affinity Capture-Western
BUB1BPARP110716616449973 Affinity Capture-MS; Affinity Capture-Western
H2AFXPARP110665216522924 18406329 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
H2AFXPARP110926816522924 18406329 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
NCAPGPARP110665216543152 Affinity Capture-Western
NCAPGPARP112208916543152 Affinity Capture-Western
NCAPD2PARP111524616543152 Affinity Capture-Western; Far Western
NCAPD2PARP110665216543152 Affinity Capture-Western; Far Western
NEDD8PARP110665216620772 Affinity Capture-MS
NEDD8PARP111081516620772 Affinity Capture-MS
SUPT16HPARP110665216682447 Biochemical Activity
SUPT16HPARP111636716682447 Biochemical Activity
ESR1PARP110665216794079 Affinity Capture-Western
ESR1PARP110840316794079 Affinity Capture-Western
PRKDCPARP110665216794079 Affinity Capture-Western
PRKDCPARP111157716794079 Affinity Capture-Western
TOP2BPARP110665216794079 Affinity Capture-Western
TOP2BPARP111300816794079 Affinity Capture-Western
H2AFYPARP111492717158748 17322296 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
H2AFYPARP110665217158748 17322296 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
HIST1H1APARP110927517214964 Biochemical Activity
HIST1H1APARP110665217214964 Biochemical Activity
H3F3APARP110665217403666 Affinity Capture-MS
H3F3APARP110927217403666 Affinity Capture-MS
MEPCEPARP112112217643375 Affinity Capture-MS
MEPCEPARP110665217643375 Affinity Capture-MS
TAF13PARP110665217643375 Affinity Capture-MS
TAF13PARP111274717643375 Affinity Capture-MS
TCEA2PARP110665217643375 Affinity Capture-MS
TCEA2PARP111278117643375 Affinity Capture-MS
TOPORSPARP110665217803295 Affinity Capture-MS
TOPORSPARP111550517803295 Affinity Capture-MS
SP1PARP111255017961220 Affinity Capture-Western; Biochemical Activity
SP1PARP110665217961220 Affinity Capture-Western; Biochemical Activity
NFATC1PARP110665218078995 Affinity Capture-Western; Reconstituted Complex
NFATC1PARP111084518078995 Affinity Capture-Western; Reconstituted Complex
PTK2PARP110665218206965 Co-fractionation
PTK2PARP111171918206965 Co-fractionation
HIST1H1CPARP110665218258596 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
HIST1H1CPARP110926118258596 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
CARM1PARP111576018280497 Affinity Capture-Western
CARM1PARP110665218280497 Affinity Capture-Western
PRMT1PARP110951218280497 Affinity Capture-Western
PRMT1PARP110665218280497 Affinity Capture-Western
HIF1APARP110665218314489 Affinity Capture-Western
HIF1APARP110933818314489 Affinity Capture-Western
TRIM28PARP111545718676401 Affinity Capture-Western
TRIM28PARP110665218676401 Affinity Capture-Western
SMARCA1PARP110665218922045 Affinity Capture-Western
SMARCA1PARP111247818922045 Affinity Capture-Western
MYBPARP111068718945670 Affinity Capture-Western
MYBPARP110665218945670 Affinity Capture-Western
NRF1PARP110665219181665 Reconstituted Complex
NRF1PARP111095519181665 Reconstituted Complex
FOXO1PARP110665219281796 Affinity Capture-Western; Reconstituted Complex
FOXO1PARP110859719281796 Affinity Capture-Western; Reconstituted Complex
HSPA2PARP110665219607827 Affinity Capture-Western; Biochemical Activity
HSPA2PARP110953819607827 Affinity Capture-Western; Biochemical Activity
USP36PARP110665219615732 Affinity Capture-MS
USP36PARP112165119615732 Affinity Capture-MS
SENP3PARP110665219622798 Biochemical Activity
SENP3PARP111759419622798 Biochemical Activity
SENP1PARP110665219622798 Biochemical Activity
SENP1PARP111893019622798 Biochemical Activity
CHD1LPARP110665219661379 19666485 Affinity Capture-MS
CHD1LPARP111492919661379 19666485 Affinity Capture-MS
RRP1BPARP111670819710015 Affinity Capture-MS
RRP1BPARP110665219710015 Affinity Capture-MS
BANF1PARP110665219759913 Affinity Capture-MS; Affinity Capture-Western
BANF1PARP111434219759913 Affinity Capture-MS; Affinity Capture-Western
IMMTPARP110665219762472 Affinity Capture-MS; Affinity Capture-Western
IMMTPARP111618519762472 Affinity Capture-MS; Affinity Capture-Western
PIAS4PARP110665219779455 Affinity Capture-Western; Reconstituted Complex
PIAS4PARP111962419779455 Affinity Capture-Western; Reconstituted Complex
AIREPARP110682320085707 Affinity Capture-MS
AIREPARP110665220085707 Affinity Capture-MS
ZBTB9PARP110665220211142 Two-hybrid
ZBTB9PARP112873620211142 Two-hybrid
TRIM29PARP110665220211142 Two-hybrid
TRIM29PARP111717720211142 Two-hybrid
LZTR1PARP110665220211142 Two-hybrid
LZTR1PARP111385220211142 Two-hybrid
GBASPARP110665220562859 Affinity Capture-MS
GBASPARP110890120562859 Affinity Capture-MS
PRKAA1PARP111154920562859 Affinity Capture-MS
PRKAA1PARP110665220562859 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
PARP1PARP1_1672, PARP1_410 Gene overview in AlzGene
Gene Symbol Poly Names Gene overview in PDGene
PARP1PARP1_-1672, PARP1_-410, rs71723709 Gene overview in PDGene
No data
Animal Model Top
  • MGI ID: MGI:1340806
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-3955'