AutismKB 2.0

Annotation Details for CSF1


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Basic Information Top
Gene Symbol:CSF1 ( MCSF,MGC31930 )
Gene Full Name: colony stimulating factor 1 (macrophage)
Band: 1p13.3
Quick LinksEntrez ID:1435; OMIM: 120420; Uniprot ID:CSF1_HUMAN; ENSEMBL ID: ENSG00000184371; HGNC ID: 2432
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005615IDA-extracellular space2460758
GO:0005788TAS-endoplasmic reticulum lumen-
GO:0005886IDA-plasma membrane-
GO:0005886TAS-plasma membrane-
GO:0016020NAS-membrane2460758
GO:0016021IEA-integral component of membrane-
GO:0048471IDA-perinuclear region of cytoplasm1739124
GO:0070062IDA-extracellular exosome23376485
GO:1990682ISS-CSF1-CSF1R complex19017797
GO ID Evidence Qualifier GO_term References
GO:0005125IDA-cytokine activity2460758
GO:0005157ISS-macrophage colony-stimulating factor receptor binding19017797
GO:0005157TAS-macrophage colony-stimulating factor receptor binding2460758
GO:0005515IPI-protein binding25416956
GO:0008083IDA-growth factor activity2460758
GO:0008083NAS-growth factor activity1791839
GO:0042803IDA-protein homodimerization activity3264878
GO ID Evidence Qualifier GO_term References
GO:0001954ISS-positive regulation of cell-matrix adhesion18566389
GO:0002158IEA-osteoclast proliferation-
GO:0003006ISS-developmental process involved in reproduction19017797
GO:0006954IEA-inflammatory response-
GO:0007169IDA-transmembrane receptor protein tyrosine kinase signaling pathway19100238
GO:0008283NAS-cell proliferation1791839
GO:0008284IDA-positive regulation of cell proliferation10652277
GO:0008284TAS-positive regulation of cell proliferation2460758
GO:0010628IDA-positive regulation of gene expression1739124
GO:0010743NAS-regulation of macrophage derived foam cell differentiation18566389
GO:0010744IDA-positive regulation of macrophage derived foam cell differentiation17244792
GO:0010759IDA-positive regulation of macrophage chemotaxis19100238
GO:0030097NAS-hemopoiesis1791839
GO:0030154NAS-cell differentiation1791839
GO:0030225TAS-macrophage differentiation2460758
GO:0030278IEA-regulation of ossification-
GO:0030316IDA-osteoclast differentiation18606301
GO:0030335ISS-positive regulation of cell migration18566389
GO:0032270IDA-positive regulation of cellular protein metabolic process1739124
GO:0032946IDA-positive regulation of mononuclear cell proliferation2460758
GO:0038145IEA-macrophage colony-stimulating factor signaling pathway-
GO:0040018IEA-positive regulation of multicellular organism growth-
GO:0042117NAS-monocyte activation18566389
GO:0042488IEA-positive regulation of odontogenesis of dentin-containing tooth-
GO:0043687TAS-post-translational protein modification-
GO:0044267TAS-cellular protein metabolic process-
GO:0045087IEA-innate immune response-
GO:0045651IDA-positive regulation of macrophage differentiation2460758
GO:0045657ISS-positive regulation of monocyte differentiation18566389
GO:0045672IDA-positive regulation of osteoclast differentiation15304486
GO:0045860ISS-positive regulation of protein kinase activity18566389
GO:0046579IEA-positive regulation of Ras protein signal transduction-
GO:0048873IEA-homeostasis of number of cells within a tissue-
GO:0060444IEA-branching involved in mammary gland duct morphogenesis-
GO:0060611IEA-mammary gland fat development-
GO:0060763IEA-mammary duct terminal end bud growth-
GO:1902228IDA-positive regulation of macrophage colony-stimulating factor signaling pathway19100238
GO:1904141IDA-positive regulation of microglial cell migration19100238
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CSF1CBL10782217353186 Affinity Capture-Western
CSF1CBL10731517353186 Affinity Capture-Western
PIK3R2CSF11078221334406 Biochemical Activity; Reconstituted Complex
PIK3R2CSF11113141334406 Biochemical Activity; Reconstituted Complex
CSF1RCSF11078228355686 Reconstituted Complex
CSF1RCSF11078238355686 Reconstituted Complex
UBCCSF110782217353186 Affinity Capture-Western
UBCCSF111316417353186 Affinity Capture-Western
SLA2CSF110782217353186 Reconstituted Complex
SLA2CSF112392817353186 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
CSF1rs1058885, rs3093054, rs756325 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:1339753
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-061215-106'