Annotation Details for NRG4

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Basic Information Top

Gene Symbol:	NRG4 ( DKFZp779N0541,DKFZp779N1944,HRG4 )
Gene Full Name:	neuregulin 4
Band:	15q24.2
Quick Links	Entrez ID:145957; OMIM: 610894; Uniprot ID:NRG4_HUMAN; ENSEMBL ID: ENSG00000169752; HGNC ID: 29862
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

AlzGene, PDGene and SZGene

Gene Ontology

Cellular Component:4 results
Molecular Function:5 results
Biological Process:9 results

GO ID	Evidence	Qualifier	GO_term	References
GO:0005576	TAS	-	extracellular region	-
GO:0005622	IEA	-	intracellular	-
GO:0005886	IEA	-	plasma membrane	-
GO:0016021	IEA	-	integral component of membrane	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0004713	TAS	-	protein tyrosine kinase activity	-
GO:0005088	TAS	-	Ras guanyl-nucleotide exchange factor activity	-
GO:0005515	IPI	-	protein binding	21516116
GO:0008083	IEA	-	growth factor activity	-
GO:0046934	TAS	-	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0000165	TAS	-	MAPK cascade	-
GO:0014066	TAS	-	regulation of phosphatidylinositol 3-kinase signaling	-
GO:0018108	IEA	-	peptidyl-tyrosine phosphorylation	-
GO:0038128	TAS	-	ERBB2 signaling pathway	-
GO:0043547	IEA	-	positive regulation of GTPase activity	-
GO:0046854	IEA	-	phosphatidylinositol phosphorylation	-
GO:0048015	TAS	-	phosphatidylinositol-mediated signaling	-
GO:1901185	TAS	-	negative regulation of ERBB signaling pathway	-
GO:2000145	TAS	-	regulation of cell motility	-

Protein-Protein Interaction

AlzGene, PDGene and SZGene

Alz Gene:0 results
PD Gene:0 results
SZ Gene:1 results

Gene Symbol	Poly Names	Gene overview in SZGene
NRG4	rs1499063, rs2455897, rs2935983, rs2959851, rs7174365, rs7183492, rs8035611, rs8036952, rs985849	Gene overview in SZGene

Animal Model

Mouse:1 results
Fruit Fly:0 results

MGI ID: MGI:1933833
Data Attributes: HomoloGene calculated

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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