AutismKB 2.0

Annotation Details for ADRA1A


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Basic Information Top
Gene Symbol:ADRA1A ( ADRA1C,ADRA1L1,ALPHA1AAR )
Gene Full Name: adrenergic, alpha-1A-, receptor
Band: 8p21.2
Quick LinksEntrez ID:148; OMIM: 104221; Uniprot ID:ADA1A_HUMAN; ENSEMBL ID: ENSG00000120907; HGNC ID: 277
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus22120526
GO:0005886TAS-plasma membrane-
GO:0005887TAS-integral component of plasma membrane8396931
GO:0030018IEA-Z disc-
GO:0030315IEA-T-tubule-
GO:0031965IDA-nuclear membrane22120526
GO ID Evidence Qualifier GO_term References
GO:0004937ISS-alpha1-adrenergic receptor activity-
GO:0004937NAS-alpha1-adrenergic receptor activity9490024
GO:0004937TAS-alpha1-adrenergic receptor activity7737411
GO:0046982IDA-protein heterodimerization activity22120526
GO ID Evidence Qualifier GO_term References
GO:0001985IEA-negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure-
GO:0001994IBA-norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure-
GO:0001996IEA-positive regulation of heart rate by epinephrine-norepinephrine-
GO:0001997IEA-positive regulation of the force of heart contraction by epinephrine-norepinephrine-
GO:0003084IEA-positive regulation of systemic arterial blood pressure-
GO:0006915TAS-apoptotic process10671514
GO:0006939TAS-smooth muscle contraction8183249
GO:0007165TAS-signal transduction8396931
GO:0007186TAS-G-protein coupled receptor signaling pathway10860850
GO:0007200IBA-phospholipase C-activating G-protein coupled receptor signaling pathway-
GO:0007202ISS-activation of phospholipase C activity-
GO:0007204IBA-positive regulation of cytosolic calcium ion concentration-
GO:0007204ISS-positive regulation of cytosolic calcium ion concentration-
GO:0007267TAS-cell-cell signaling8396931
GO:0007512IEA-adult heart development-
GO:0007568ISS-aging-
GO:0008285TAS-negative regulation of cell proliferation10860850
GO:0009725ISS-response to hormone-
GO:0016049IEA-cell growth-
GO:0032230ISS-positive regulation of synaptic transmission, GABAergic-
GO:0035024ISS-negative regulation of Rho protein signal transduction-
GO:0035265IEA-organ growth-
GO:0035556TAS-intracellular signal transduction10671514
GO:0042493ISS-response to drug-
GO:0043410IDA-positive regulation of MAPK cascade22120526
GO:0045760ISS-positive regulation of action potential-
GO:0045907IBA-positive regulation of vasoconstriction-
GO:0045907ISS-positive regulation of vasoconstriction-
GO:0045987IBA-positive regulation of smooth muscle contraction-
GO:0060073IEA-micturition-
GO:0060402ISS-calcium ion transport into cytosol-
GO:0060452ISS-positive regulation of cardiac muscle contraction-
GO:0070374ISS-positive regulation of ERK1 and ERK2 cascade-
GO:0071880IBA-adenylate cyclase-activating adrenergic receptor signaling pathway-
GO:0090037ISS-positive regulation of protein kinase C signaling-
GO:0097195IEA-pilomotor reflex-
Protein-Protein Interaction Top
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
ADRA1Ars1048101 Gene overview in AlzGene
No data
Gene Symbol Poly Names Gene overview in SZGene
ADRA1AADRA1A_-1873G/A, ADRA1A_-2760A/C, ADRA1A_-4884A/G, ADRA1A_-6274C/T, ADRA1A_-7255A/G, ADRA1A_-9625G/A, ADRA1A_Arg492Cys, rs1048101, rs1383914, rs2046186, rs2644627, rs4548188, rs526302, rs539144, rs563097, rs580739, rs66720581, rs937351 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:104773
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-2831'