AutismKB 2.0

Annotation Details for CTGF


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Basic Information Top
Gene Symbol:CTGF ( CCN2,HCS24,IGFBP8,MGC102839,NOV2 )
Gene Full Name: connective tissue growth factor
Band: 6q23.2
Quick LinksEntrez ID:1490; OMIM: 121009; Uniprot ID:CTGF_HUMAN; ENSEMBL ID: ENSG00000118523; HGNC ID: 2500
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005578IEA-proteinaceous extracellular matrix-
GO:0005615IEA-extracellular space-
GO:0005794IDA-Golgi apparatus-
GO:0005801IEA-cis-Golgi network-
GO:0005829IEA-cytosol-
GO:0005886TAS-plasma membrane10809757
GO:0005938IEA-cell cortex-
GO:0043231IDA-intracellular membrane-bounded organelle-
GO:0048471IEA-perinuclear region of cytoplasm-
GO ID Evidence Qualifier GO_term References
GO:0001968IEA-fibronectin binding-
GO:0005178IEA-integrin binding-
GO:0005515IPI-protein binding16457822
GO:0005520IEA-insulin-like growth factor binding-
GO:0008022IPI-protein C-terminus binding9927660
GO:0008083IEA-growth factor activity-
GO:0008201IEA-heparin binding-
GO ID Evidence Qualifier GO_term References
GO:0001502IEA-cartilage condensation-
GO:0001503IEA-ossification-
GO:0001525IEA-angiogenesis-
GO:0001558IEA-regulation of cell growth-
GO:0001894IEA-tissue homeostasis-
GO:0006367TAS-transcription initiation from RNA polymerase II promoter-
GO:0007160IEA-cell-matrix adhesion-
GO:0007229IEA-integrin-mediated signaling pathway-
GO:0007568IEA-aging-
GO:0008284IEA-positive regulation of cell proliferation-
GO:0008543IEA-fibroblast growth factor receptor signaling pathway-
GO:0008544TAS-epidermis development10809757
GO:0009611TAS-response to wounding10809757
GO:0009749IEA-response to glucose-
GO:0010628IEA-positive regulation of gene expression-
GO:0010629IEA-negative regulation of gene expression-
GO:0016477IEA-cell migration-
GO:0019216TAS-regulation of lipid metabolic process-
GO:0030154IEA-cell differentiation-
GO:0030324IEA-lung development-
GO:0032330IEA-regulation of chondrocyte differentiation-
GO:0032355IEA-response to estradiol-
GO:0032967IEA-positive regulation of collagen biosynthetic process-
GO:0034059IEA-response to anoxia-
GO:0035556IEA-intracellular signal transduction-
GO:0035988IEA-chondrocyte proliferation-
GO:0043200IEA-response to amino acid-
GO:0043280IEA-positive regulation of cysteine-type endopeptidase activity involved in apoptotic process-
GO:0043434IEA-response to peptide hormone-
GO:0045597IDA-positive regulation of cell differentiation20008146
GO:0046330IDA-positive regulation of JNK cascade20008146
GO:0050867IEA-positive regulation of cell activation-
GO:0051385IEA-response to mineralocorticoid-
GO:0051496IDA-positive regulation of stress fiber assembly20008146
GO:0060401IEA-cytosolic calcium ion transport-
GO:0060452IEA-positive regulation of cardiac muscle contraction-
GO:0060548IEA-negative regulation of cell death-
GO:0070278IEA-extracellular matrix constituent secretion-
GO:0070318IEA-positive regulation of G0 to G1 transition-
GO:0070374IDA-positive regulation of ERK1 and ERK2 cascade20008146
GO:0070542IEA-response to fatty acid-
GO:0071897IEA-DNA biosynthetic process-
GO:0072593IEA-reactive oxygen species metabolic process-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
FBLN1CTGF1078729927660 Reconstituted Complex
FBLN1CTGF1084869927660 Reconstituted Complex
VEGFACTGF11326511744618 Affinity Capture-Western; Reconstituted Complex
VEGFACTGF10787211744618 Affinity Capture-Western; Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:95537
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-102'