AutismKB 2.0

Annotation Details for CTLA4


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Basic Information Top
Gene Symbol:CTLA4 ( CD,CD152,CELIAC3,CTLA-4,GRD4,GSE,ICOS,IDDM12 )
Gene Full Name: cytotoxic T-lymphocyte-associated protein 4
Band: 2q33.2
Quick LinksEntrez ID:1493; OMIM: 123890; Uniprot ID:CTLA4_HUMAN; ENSEMBL ID: ENSG00000163599; HGNC ID: 2505
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005794IDA-Golgi apparatus15814706
GO:0005886TAS-plasma membrane-
GO:0005887TAS-integral component of plasma membrane3220103
GO:0009897IDA-external side of plasma membrane18641304
GO:0045334IDA-clathrin-coated endocytic vesicle15814706
GO:0048471IDA-perinuclear region of cytoplasm15814706
GO:0098636IDA-protein complex involved in cell adhesion7544393
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding7807015
GO ID Evidence Qualifier GO_term References
GO:0002250IEA-adaptive immune response-
GO:0006955TAS-immune response3220103
GO:0006974IMP-cellular response to DNA damage stimulus17875758
GO:0030889IMP-negative regulation of B cell proliferation17875758
GO:0031295TAS-T cell costimulation-
GO:0042130IEA-negative regulation of T cell proliferation-
GO:0043065IMP-positive regulation of apoptotic process17875758
GO:0045590IDA-negative regulation of regulatory T cell differentiation18641304
GO:0050777IEA-negative regulation of immune response-
GO:0050853IMP-B cell receptor signaling pathway17875758
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CTLA4CD801078757545666 11279502 Co-crystal Structure; Reconstituted Complex
CTLA4CD801073797545666 11279502 Co-crystal Structure; Reconstituted Complex
CTLA4CD8610787511279501 Co-crystal Structure
CTLA4CD8610738011279501 Co-crystal Structure
CTLA4AP2M11078759200449 11583591 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
CTLA4AP2M11075879200449 11583591 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
FYNCTLA41078759712716 Affinity Capture-Western
FYNCTLA41088109712716 Affinity Capture-Western
LCKCTLA41078759712716 Affinity Capture-Western
LCKCTLA41101249712716 Affinity Capture-Western
LYNCTLA41078759712716 Affinity Capture-Western
LYNCTLA41102459712716 Affinity Capture-Western
AP1M1CTLA41144219812899 Co-crystal Structure
AP1M1CTLA41078759812899 Co-crystal Structure
JAK2CTLA410787510842319 Affinity Capture-Western
JAK2CTLA410992010842319 Affinity Capture-Western
CTLA4CTLA410787511279502 Co-crystal Structure
PPP2R5ACTLA411151711994459 Affinity Capture-Western; Two-hybrid
PPP2R5ACTLA410787511994459 Affinity Capture-Western; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
CTLA4rs231775, rs3087243, rs5742909 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:88556
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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