AutismKB 2.0

Annotation Details for ADRA2B


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Basic Information Top
Gene Symbol:ADRA2B ( ADRA2L1,ADRA2RL1,ADRARL1,ALPHA2BAR )
Gene Full Name: adrenergic, alpha-2B-, receptor
Band: 2q11.2
Quick LinksEntrez ID:151; OMIM: 104260; Uniprot ID:ADA2B_HUMAN; ENSEMBL ID: ENSG00000222040; HGNC ID: 282
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005886TAS-plasma membrane-
GO:0005887TAS-integral component of plasma membrane2164221
GO ID Evidence Qualifier GO_term References
GO:0004938IDA-alpha2-adrenergic receptor activity17215105
GO:0005515IPI-protein binding16531006
GO:0051379IDA-epinephrine binding17215105
GO ID Evidence Qualifier GO_term References
GO:0003056IEA-regulation of vascular smooth muscle contraction-
GO:0007186TAS-G-protein coupled receptor signaling pathway2164221
GO:0007267TAS-cell-cell signaling2164221
GO:0007565IEA-female pregnancy-
GO:0010700NAS-negative regulation of norepinephrine secretion16531006
GO:0010700TAS-negative regulation of norepinephrine secretion19477270
GO:0030168IEA-platelet activation-
GO:0032148IDA-activation of protein kinase B activity17215105
GO:0032811NAS-negative regulation of epinephrine secretion16531006
GO:0035625IDA-epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway17215105
GO:0045666IDA-positive regulation of neuron differentiation17215105
GO:0045777IEA-positive regulation of blood pressure-
GO:0070474IEA-positive regulation of uterine smooth muscle contraction-
GO:0071880IBA-adenylate cyclase-activating adrenergic receptor signaling pathway-
GO:0071883IDA-activation of MAPK activity by adrenergic receptor signaling pathway17215105
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
EIF2B1ADRA2B1082869235896 Reconstituted Complex
EIF2B1ADRA2B1066609235896 Reconstituted Complex
PPP1R9BADRA2B12420211154706 Reconstituted Complex
PPP1R9BADRA2B10666011154706 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:87935
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-021010-2'