AutismKB 2.0

Annotation Details for CTSH


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Basic Information Top
Gene Symbol:CTSH ( ACC-4,ACC-5,CPSB,DKFZp686B24257,MGC1519,minichain )
Gene Full Name: cathepsin H
Band: 15q25.1
Quick LinksEntrez ID:1512; OMIM: 116820; Uniprot ID:CATH_HUMAN; ENSEMBL ID: ENSG00000103811; HGNC ID: 2535
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000932IDA-P-body-
GO:0005576TAS-extracellular region-
GO:0005615IDA-extracellular space9050938
GO:0005764IDA-lysosome1837142
GO:0005829IDA-cytosol9050938
GO:0034774TAS-secretory granule lumen-
GO:0043231IDA-intracellular membrane-bounded organelle-
GO:0070062IDA-extracellular exosome23376485
GO:0097208IDA-alveolar lamellar body18216060
GO:0097486TAS-multivesicular body lumen-
GO:1904724TAS-tertiary granule lumen-
GO:1904813TAS-ficolin-1-rich granule lumen-
GO ID Evidence Qualifier GO_term References
GO:0004175IDA-endopeptidase activity14766755
GO:0004177IDA-aminopeptidase activity15127951
GO:0004197IDA-cysteine-type endopeptidase activity6203523
GO:0004197TAS-cysteine-type endopeptidase activity2849458
GO:0004252ISS-serine-type endopeptidase activity-
GO:0005515IPI-protein binding6203523
GO:0008233IDA-peptidase activity18216060
GO:0008233TAS-peptidase activity-
GO:0008234IDA-cysteine-type peptidase activity8811434
GO:0008656IDA-cysteine-type endopeptidase activator activity involved in apoptotic process20435891
GO:0030108IDA-HLA-A specific activating MHC class I receptor activity16822283
GO:0070324IDA-thyroid hormone binding21217776
GO ID Evidence Qualifier GO_term References
GO:0001656ISS-metanephros development-
GO:0001913ISS-T cell mediated cytotoxicity-
GO:0002250IEP-adaptive immune response15196205
GO:0002764IDA-immune response-regulating signaling pathway16822283
GO:0006508IDA-proteolysis6203523
GO:0006508TAS-proteolysis2849458
GO:0006915IEA-apoptotic process-
GO:0006919IEA-activation of cysteine-type endopeptidase activity involved in apoptotic process-
GO:0008284ISS-positive regulation of cell proliferation-
GO:0010628IDA-positive regulation of gene expression21217776
GO:0010634ISS-positive regulation of epithelial cell migration-
GO:0010813IDA-neuropeptide catabolic process15127951
GO:0010815IDA-bradykinin catabolic process15127951
GO:0010952IDA-positive regulation of peptidase activity20435891
GO:0019882TAS-antigen processing and presentation15196205
GO:0030335IDA-positive regulation of cell migration21217776
GO:0031638IDA-zymogen activation20435891
GO:0031648IMP-protein destabilization17500053
GO:0032526ISS-response to retinoic acid-
GO:0033619IDA-membrane protein proteolysis14766755
GO:0043066ISS-negative regulation of apoptotic process-
GO:0043129IDA-surfactant homeostasis18216060
GO:0043312TAS-neutrophil degranulation-
GO:0044267TAS-cellular protein metabolic process-
GO:0045766ISS-positive regulation of angiogenesis-
GO:0051603IBA-proteolysis involved in cellular protein catabolic process-
GO:0060448ISS-dichotomous subdivision of terminal units involved in lung branching-
GO:0070371IDA-ERK1 and ERK2 cascade21217776
GO:0097067IEP-cellular response to thyroid hormone stimulus21217776
GO:2001235IBA-positive regulation of apoptotic signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CTSHCSTA10789212581647 Co-crystal Structure
CTSHCSTA10785712581647 Co-crystal Structure
CTSHCSTB10789211514663 Reconstituted Complex
CTSHCSTB10785811514663 Reconstituted Complex
Gene Symbol Interactant Interaction ID References Description
CTSHCSTA1912012581647 Lysosomal cysteine protease cathepsin H interacts with intracellular protease inhibitor stefin A. This interaction is modeled based on a demonstrated interaction between porcine cathepsin H and human stefinA.
No data
AlzGene, PDGene and SZGene Top
No data
Gene Symbol Poly Names Gene overview in PDGene
CTSHrs1036937, rs894785 Gene overview in PDGene
No data
Animal Model Top
  • MGI ID: MGI:107285
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-3539'